Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. Join them; it only takes a minute:

Sign up
Here's how it works:
  1. Anybody can ask a question
  2. Anybody can answer
  3. The best answers are voted up and rise to the top

What effect do SSRIs have on the expression of the ligand-gated ion channel, the 5-HT3 receptor?

share|improve this question

SSRI's theoretically increase Serotonin levels. Serotonin is an agonist to the 5HT-3 receptors. The 5HT-3a primarily associated with the upper gut and the 5HT-3b with the lower gut. I would guess that theoretically again, SSRI's would tend to increase nausea, emesis, and diarrhea. There may be other effects, but these are the ones I have researched.

The anti-emetics Dolasetron, Ondansetron, Granisetron, and Tropisetron are 5HT-3 antagonists.

share|improve this answer

Your Answer


By posting your answer, you agree to the privacy policy and terms of service.

Not the answer you're looking for? Browse other questions tagged or ask your own question.