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Why do antidepressants take so long to reach efficacy? I've read of theories about it perhaps being due to the strength of negative feedback via serotonergic and adrenergic autoreceptors during the first few weeks of treatment. What I'm looking for in an answer is the following:

  • The current theories regarding why currently-in-practise antidepressant regimens have a delayed onset of action.
  • The evidence for this theories.
  • How these theories fit in with the monoamine hypothesis or whether it is inconsistent with the monoamine hypothesis and how.
  • Possible solutions to this problem of delayed responses to antidepressant therapy.

All of this is strictly theoretical, there are no actual people involved here, this is simply a scientific inquiry.

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