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Which mixed opioid agonist/antagonist are approved for Human Use in Europe and/or the USA? I know of:

  • Buprenorphine
  • Butorphanol
  • Nalbuphine
  • Pentazocine

Are there any others? If so I would like you to list their respective partition coefficients ($\log{P} $), binding affinities (Ki), EC50's, IC50's at the opioid receptors ($\kappa$, $\delta$, $\mu$), binding profile and countries where they are approved for clinic use.

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