Is it known exactly why the brain needs sleep? What's dropping low / going high when we experience mental fatigue? I can see why low glucose could result in mental fatigue, are other reasons known?
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This is not the biochemistry, but the brain regions involved are described in this article about an fMRI study: http://www.sciencedaily.com/releases/2012/12/121210101630.htm EDIT: From what I can tell, mental fatigue is attributed to low oxygenation levels. Here's a study that examines the effect of creatine in preventing mental fatigue: http://jtoomim.org/brain-training/watanabe2001-creatine-reduces-mentalfatigue.pdf |
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