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I have been looking at this antibiotic called doxycycline which is used mainly as an antibiotic. It has however some interesting anti-inflammatory properties. Does anyone know where these anti-inflammatory properties come from, chemically?

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Doxycyline inhibits iNOS and TNF-alpha expression. It also influences secretion of IL-1beta, IL-8, and TNF-alpha, as well as other inflammatory cytokines.

[These are results collected from multiple systems.]

For appropriate references, see: Leite et al (2011). Anti-inflammatory properties of Doxycycline and Minocycline in experimental models: an in vivo and in vitro comparative study. Inflammopharmocology.

As for the chemistry of how doxycycline accomplishes these things, I'm afraid I don't know the answer, but hopefully, this gives you a place to start.

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