I have been looking at this antibiotic called doxycycline which is used mainly as an antibiotic. It has however some interesting anti-inflammatory properties. Does anyone know where these anti-inflammatory properties come from, chemically?
Doxycyline inhibits iNOS and TNF-alpha expression. It also influences secretion of IL-1beta, IL-8, and TNF-alpha, as well as other inflammatory cytokines.
[These are results collected from multiple systems.]
For appropriate references, see: Leite et al (2011). Anti-inflammatory properties of Doxycycline and Minocycline in experimental models: an in vivo and in vitro comparative study. Inflammopharmocology.
As for the chemistry of how doxycycline accomplishes these things, I'm afraid I don't know the answer, but hopefully, this gives you a place to start.