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On pg. 410 of Goodman and Gilman's The Pharmacological Basis of Therapeutics 12th Edition the term "MUSCARINIC CHOLINERGIC" is used (in the context of side effects of antidepressant agents) with affinities toward said receptor(s) given in the column below. I know what muscarinic cholinergic receptors are but I'm wondering which receptor in particular is this affinity for or is it an average of all five? I would think it would either be an average or for the M1 receptor as it is referred to in the next chapter, "Pharmacotherapy of Psychosis and Mania" in the context of side effects too with binding affinities given (pg. 427).

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Figure 1: Antidepressant Affinities Table

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Figure 2: Antipsychotic Affinities Table

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put on hold as unclear what you're asking by Chris, Cornelius, MattDMo, kmm Nov 25 at 2:26

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It would be helpful if you reproduced the relevant sections, as not everybody with knowledge of this topic is likely to have access to your book. –  dd3 Apr 16 '13 at 19:50
@dd3 OK, here are the relevant tables. –  Brenton Horne Apr 16 '13 at 19:55

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