Why is it that when secretory rate increases in the pancreas the concentration of chloride ions decreases, and the concentration of bicarbonate increases in the production of isotonic NaCl secretion?
The modification that goes on in the duct of the acinus is dependent on flow. If the flow is faster, then less ions can be reabsorbed from the primary secretion. In the pancreas, chloride ions are removed, so surely their concentration should go up as the flow increases?
Bicarbonate on the other hand is added to the primary secretion in the duct. So shouldn't its concentration in the secretion stay the same or even increase as flow increases?