I'm reading a text (Wagner, 2007) on identifying positive selection. In paper, the author says that low complexity regions are known to be associated with relaxed selection. I'm trying to understand why this is true. I get that if the region is under relaxed selection then most mutations would be tolerated but why would that lead to low complexity (other than something like slippage during DNA replication)
It's in the section: "Little overlap between variation clusters and low complexity regions"
Wagner A. 2007. Rapid Detection of Positive Selection in Genes and Genomes Through Variation Clusters. Genetics 176(4): 2451–2463.