A neurotropic virus is a virus which capable of infecting nerve cells.
Herpes simplex virus (HSV) has low neuroinvasivesess and high neurovirulence. HSV is transmitted in vesicle fluid, saliva and vaginal secretions. So the site of infection determines the disease - "mixing and matching of mucous membranes".
Source: Murray 2013, Medical Microbiology.
Why is herpes virus neurotropic?