I did an expression profiling from publicly available RNAseq data for mouse tissues. While for liver and testes I am getting expected proteins in the top highly expressed mRNAs, for brain I am getting ferritin (Ferritin heavy chain 1: Fth1) as the top expressed mRNA!
There are a few studies which report elevated ferritin and iron in neurodegenerative diseases while some others have implicated its role in ageing.
I haven't come across any study on iron metabolism in the normal brain. Does iron metabolism play an important role in the function of the brain?
- The data that I am talking about, has the SRA accession number- SRR652247 (I tried all three runs submitted in SRA)
- The mice used in the experiment were 11 weeks old
- I used bowtie -> eXpress for quantification of RNAseq reads.