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Background

E. coli is prevalent everywhere but only some strains produce toxins harmful to humans, such as E. coli O157:H7.

Questions

1) Would anyone know if these strains are always producing this toxin or is it only under certain conditions?

2) Is it the toxin itself that makes people sick and not the presence of the bacteria?

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1 Answer

up vote 2 down vote accepted

1) That depends on the fact, if the protein in the bacterium is regulated somehow or it is constantly expressed. That could be different for different toxins and even for the same toxins in different strains, so there is no plain answer for all strains and toxins.

2) That, I guess, also depends on the toxin. There are some that are basically toxins, but do not make people sick. Sometimes, the toxin is produced by the bacterium, but never secreted. Sometimes it is secreted, but has no influence on the host. Sometimes the host does react to a toxin. But the human immune system can also react to the bacteria before they start producing toxin (if it is somehow regulated) or before the toxin concentration secreted by the bacteria starts to be harmful.

In the case of E. coli O157:H7, this paper states it produces two different Shigatoxins (that were supposedly causing its pathogeny), but also some other toxins/toxin-like proteins.

I have studied some E.coli genomes previously, some non-pathogenic had several toxin-related genes, some pathogenic had actually none at all (at least none that could be annotated).

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Thanks. I'm looking over that paper. In your research did you ever come across some info as to what E.coli uses it's toxin for? I might actually just post that as a separate question.. –  Usman Mutawakil Jul 13 '13 at 20:43
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I was not quite interested in the Shigatoxines, as they did not occur in the specific strain I was mainly interested in. I guess, secreting toxines is basically a fitness factor, as it could kill off competitors for nutrients. –  skymninge Jul 15 '13 at 6:09
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