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Is it possible to have both type-1 (insulin-dependent) and type-2 (non-insulin-dependent) diabetes mellitus? That is, to have both insulin resistance and zero (or negligible) insulin production? If not, why not? And if so, then how common is this (among humans with each type of diabetes)? Any information on why the comorbidity may be high or low is also most welcome.

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I've been thinking about the "how common" part of your question, and it's tricky to awnser world wide as we see significant cultural variation. Perhaps you would settle for prevalence in a group of countries you are interested in? –  Atl LED Jul 13 '13 at 18:18
    
@AtlLED, any answer that answers that part of the question about any region would be most welcome. –  msh210 Jul 14 '13 at 4:24

1 Answer 1

Yes you could think of an individual as having both(1). A good place to start looking at "newer" diabetes other than the classic 1 and 2 is latent autoimmune diabetes (LADA). Though, I don't know if one would say you had no insulin production. It would seem as though patients exhibit some characteristics of both types(2), and indeed there maybe a continuum possible(3) between ether "pure" type on each extreme.

(1) The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study. Diabetologia. 2012 Mar;55(3):689-93. doi: 10.1007/s00125-011-2378-z. Epub 2011 Nov 23.

(2) Latent autoimmune diabetes (LADA) is perched between type 1 and type 2: evidence from adults in one region of Spain. Diabetes/Metabolism Research and Reviews 2013; 1520-7560.

(3) Latent autoimmune diabetes in adults: evidences for diabetes spectrum?.Chin Med J 2013;126:783-788

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+1, and thanks. –  msh210 Jul 14 '13 at 4:25
    
@msh210 off idle curiosity, was there something more you were looking for in an acceptable answer? –  Atl LED Aug 21 '13 at 15:27
    
Latent autoimmune diabetes is interesting and even answers my question, but I was thinking more of, and looking for, cases of independently contracted types 1 and 2 diabetes. –  msh210 Aug 21 '13 at 16:18

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