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What makes substances allergenic?

Is it possible to tell or rule out (potentially a priori) whether any given substance or compound is likely and how likely to cause allergies with high confidence, without the need to conduct ...
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Oral allergy syndrom, continuation of continuous consumption of allergen

Wikipedia states on its page that In addition, patients are advised to avoid the triggering foods, particularly nuts. And same thing goes for webmd.com The basic rule: If a food makes you ...