Programmed cell death. It is designed to prevent old damaged cells from mutating into neoplastic (cancer) cells.

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Can oncogenesis happen without apoptosis pathway being affected?

Has there ever been incidences of one or more cancerous cells having all it's cell-death pathways and apoptosis mechanisms intact and functional?
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molecular indicators of apoptosis: clarification needed

I understand that DNA fragmentation is a molecular indicator of apoptosis. What distinguishes this as a hallmark of programmed cell death, versus one of necrosis?
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Regarding apoptosis and inhibitors

If there is an apoptosis shut-off mechanism of any kind, one could call it a null-apoptosis mechanism. If this is possible, could there be a null-apoptosis inhibitor? Something that inhibits an ...
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Concerning Apoptosis

What if cellular growth and repair is 'forced' to occur repeatedly in a region where it wouldn't normally happen , if the biological area was 'healthier'. Could this more aggressive cellular growth ...
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1answer
47 views

What is Pan for in pan-caspase?

A simple question (I could not find it on internet): What is Pan for in pan-caspase? Is it any different from the term 'caspase' ?
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About stem cells and Cancer

Do stem cells have an apoptosis mechanism and , if they do could this be used to repair the cell self-destruction pathways in a cancer cell?
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Do Fatty Acid Synthase Inhibitors Selectively induce Apoptosis in Cancer cells without inducing the same in healthy human cells?

Do Fatty Acid Synthase (FAS) Inhibitors (e.g. cerulenin) selectively induce apoptosis in cancer cells without inducing the same in healthy human cells?
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What models are used for the different pathways of apoptosis?

We are trying to find references for experimental models of different pathways of apoptosis (caspase-dependent and -independent intrinsic apoptosis, death receptor type-1 and -2 mediated apoptosis, ...
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To understand Nitric oxide, iNOS and Tumour cells

I have this figure about nitric oxide and tumor which is for schematic for me to understand it The figure should probably say that tumour cell is induced by NO or alone to go apoptosis and it ...