Questions pertaining to the production of an immune response to self tissues/molecules.

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6
votes
2answers
115 views

Why is there no way to remove an immune response?

We've known for a long time now how to "add a new entry to the database," as it were, of immune responses. It's called vaccination, and it's been one of the greatest success stories in the history of ...
5
votes
1answer
50 views

A possible cause of autoimmunity

I read that Doherty and Zinkernagel found that MHC- heterozygotes present more antigens to the immune system than homozygotes; yet, the infected heterozygous mice in their experiment all ...
4
votes
1answer
50 views

Is there a link between autoimmune diseases and X-chromosome inactivation?

I was reading about the necessity of niche formations to adequate development of blood progenitors and this idea reminded me of the patchy inactivation of the X chromosome which followed that maybe, ...
4
votes
1answer
47 views

Immunity during pregnancy

I have learnt that our immune system distinguishes self from non-self by using MHC. So a mother during pregnancy should also develop antibodies against the fetus as it is also a genetically different ...
3
votes
1answer
38 views

When was it determined that Type 1 Diabetes is an autoimmune disease?

I just found out today that type 1 diabetes is an autoimmune disease. When was this discovered?
3
votes
2answers
2k views

Presence of MHC on red blood cells

Do red blood cells have no MHC? (I have often heard that they do not.) If so why are they not destroyed by immune cells?
3
votes
1answer
122 views

Do macrophages engulf mtDNA?

Let us assume that in a human body, a mitochondrial DNA is released to extracellular environment. We know that mtDNA inheritance is solely matrilineal. So the question is, If your mitochondrial DNA ...
3
votes
2answers
146 views

How does Humira work when injected into patients with rheumatoid arthritis?

OK, I have rheumatoid arthritis and I've been injecting Humira 2 times a month for the last 8 months. As far as I know rheumatoid arthritis is simply an immune system disorder which makes the immune ...
2
votes
1answer
47 views

Autoimmunity and central tolerance

Where in the body are self antigens important? In terms of central tolerance and autoimmunity, but also in terms of T cell activation?
1
vote
3answers
60 views

Cell identification by Body Cells

How do the B-cells and T-cells recognize or distinguish a body cell from a foreign particle? I suspect something to do with this causes Auto Immune Disorders.
1
vote
0answers
104 views

What are the biomarkers for autoimmune diseases? Significancy, related diseases, detecting mechanisms [closed]

I think this is a trick question, since to understand what are the biomarkers we need to understand what are the encoding genes that make the antibodies. Then, I would explain the reason why to ...
0
votes
1answer
50 views

What is immunosuppression? Why would one use it? [closed]

What is immunosuppression? I know it is used in cancer patients, but why would one want to suppress the immune system? Do homeopathic physicians ever use immunosuppression, or do only allopathic ...
0
votes
1answer
26 views

Could transfusion of a different blood type cure blood-based cancers?

Different antigen detection triggers an immune system response that could perhaps stimulate mitochondria and such in killing cancer cells - something like chemo without the hair-loss?
-3
votes
1answer
73 views

Can cancer be an immune system disorder? [closed]

Can cancer result from a weakened immune system? Would this mean that cancer could be considered an immune system disorder?