Questions pertaining to the production of an immune response to self tissues/molecules.

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8
votes
2answers
135 views

Why is there no way to remove an immune response?

We've known for a long time now how to "add a new entry to the database," as it were, of immune responses. It's called vaccination, and it's been one of the greatest success stories in the history of ...
5
votes
2answers
69 views

Autoimmunity and central tolerance

Where in the body are self antigens important? In terms of central tolerance and autoimmunity, but also in terms of T cell activation?
5
votes
1answer
51 views

A possible cause of autoimmunity

I read that Doherty and Zinkernagel found that MHC- heterozygotes present more antigens to the immune system than homozygotes; yet, the infected heterozygous mice in their experiment all ...
5
votes
1answer
48 views

How does de-myelination occur in multiple sclerosis?

From what I understand, only the oligodendrocytes are affected in multiple sclerosis, and they are attacked by T cells which cross the blood-brain barrier. This leads me to two questions: How is the ...
4
votes
1answer
53 views

Is there a link between autoimmune diseases and X-chromosome inactivation?

I was reading about the necessity of niche formations to adequate development of blood progenitors and this idea reminded me of the patchy inactivation of the X chromosome which followed that maybe, ...
4
votes
1answer
52 views

Immunity during pregnancy

I have learnt that our immune system distinguishes self from non-self by using MHC. So a mother during pregnancy should also develop antibodies against the fetus as it is also a genetically different ...
3
votes
1answer
43 views

When was it determined that Type 1 Diabetes is an autoimmune disease?

I just found out today that type 1 diabetes is an autoimmune disease. When was this discovered?
3
votes
2answers
3k views

Presence of MHC on red blood cells

Do red blood cells have no MHC? (I have often heard that they do not.) If so why are they not destroyed by immune cells?
3
votes
1answer
153 views

Do macrophages engulf mtDNA?

Let us assume that in a human body, a mitochondrial DNA is released to extracellular environment. We know that mtDNA inheritance is solely matrilineal. So the question is, If your mitochondrial DNA ...
3
votes
2answers
270 views

How does Humira work when injected into patients with rheumatoid arthritis?

OK, I have rheumatoid arthritis and I've been injecting Humira 2 times a month for the last 8 months. As far as I know rheumatoid arthritis is simply an immune system disorder which makes the immune ...
3
votes
1answer
102 views

How do genetic chimeras with different blood types not die?

If a person is a chimera and has two different blood types in his veins, how does he not die? Shouldn't the immune system attack one of the blood types? In 1953 a human chimera was reported in the ...
2
votes
1answer
28 views

Can stress-induced cortisol reduce diabetes type I?

Let us consider a patient with type 1 diabetes. I think it would be safe to say that diabetes is an autoimmune disease. Now let us suppose this patient comes under stress. As far as I know, cortisol ...
2
votes
1answer
65 views

How does Celiac's Disease cause people to stop growing?

In all of the sites I've looked on, one of the symptoms of Celiac's Disease is the failure to grow in children. Why would an immune attack against gluten cause stunted growth? Celiac.org states: ...
1
vote
3answers
65 views

Cell identification by Body Cells

How do the B-cells and T-cells recognize or distinguish a body cell from a foreign particle? I suspect something to do with this causes Auto Immune Disorders.
1
vote
5answers
84 views

Can your immune system's cells destroy you? (Critical thinking and Fictional sense)

In an imaginary sense, If you alone were replicated into 2 so that there should now be 2 of "you" (meaning you both have the same DNA). Then let's say one of you shrunk to the size of a bacteria, and ...
1
vote
0answers
16 views

What happened to my immune system? [closed]

when I was a child I had frequent asthma attacks, skin rashes from touching pretty much anything and my joitns were swelling, also my eyes would get inflammation all the time. It has since subsided ...
1
vote
0answers
19 views

Are there any auto-immune diseases caused by T cells not detaching from antigen presenting cells (APCs)?

By not detaching I'm referring to after they have formed an immunological synapse, if they don't ever detach.
1
vote
0answers
25 views

Is this description of etiology of celiac disease correct?

There is a detailed and, to my inexpert eyes, plausible description of the etiology of celiac disease and other autoimmune disorders posted here: http://no-gluten.org/CeliacDisease.htm Is it is at ...
0
votes
1answer
67 views

What is immunosuppression? Why would one use it? [closed]

What is immunosuppression? I know it is used in cancer patients, but why would one want to suppress the immune system? Do homeopathic physicians ever use immunosuppression, or do only allopathic ...
0
votes
1answer
29 views

Could transfusion of a different blood type cure blood-based cancers?

Different antigen detection triggers an immune system response that could perhaps stimulate mitochondria and such in killing cancer cells - something like chemo without the hair-loss?
0
votes
0answers
5 views

Cure for high anti TPO levels to attain pregnancy successfully [migrated]

Can a person with high anti tpo levels be treated to have successful pregnancy ? Does intralipid infusion help in this process ? Does prednisone help in this process ?
-3
votes
1answer
91 views

Can cancer be an immune system disorder? [closed]

Can cancer result from a weakened immune system? Would this mean that cancer could be considered an immune system disorder?