The study of chemistry within the scope of biology: the compounds that occur and the reactions involving them in living organisms.

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1answer
38 views

How do you express and detect GLP-1 receptors?

I am currently working with a peptide which is an analogue for glp-1, but during invitro studies am not able to detect for the presence of GLP1- receptors. The cell line used is Min-6. How do I detect ...
3
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2answers
25 views

Concentration dependent cellular processes

Are there any famous biological processes that depend strongly on a chemical concentration reaching a particular value, like some sort of switch? E.g. if concentration of chemical x reaches ...
4
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1answer
100 views

which signalling pathway is involved in cancer?

Columnar epithelial cells from the colonic mucosa are studied to identify abnormalities in cell signaling pathways. Abnormal epithelial cells from colonic adenocarcinoma are shown to have a mutation ...
2
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1answer
30 views

What is the biding site code recognized by the parts of the spliceosome

Another question about another Youtube video. At 0:50, the splicing process begins to remove the non-coding section of the DNA (intron), so the different parts of the spliceosome attach to the borders ...
4
votes
2answers
182 views

Why is oxygen needed for the electron transfer phosphorylation?

I understand that oxygen is the acceptor of electrons and hydrogen ions during the electron transfer phosphorylation, the last step off the ATP-producing aerobic respiration. But why? Aren't there ...
1
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1answer
44 views

What is an effective method for putting on blue rubber butyl stoppers?

They look like this. We have to do a lot of gas sampling and these are really difficult to assemble. I've been scouring the internet for advice but there are none. Do you have experience with ...
4
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4answers
161 views

Specificity of Protein Kinases in Signaling Pathways..?

In most of the signaling pathways the activated receptor when activates Protein Kinase through the action of secondary messenger, then these protein kinases almost always phosphorylate on the specific ...
2
votes
1answer
38 views

Why do oncogenes show genetic dominance?

As we know that tumor suppressor gene causes cancer only when both the alleles are recessive in nature.But in case of oncogenes if only one allele is dominant it can cause cancer.Why in case of ...
4
votes
2answers
91 views

Effect of steroid hormone on specific cells?

As steroid hormones can pass through the plasma membrane by simple diffusion because they are lipid derived hormones, it means that they are capable of passing through every cell of our body, BUT why ...
2
votes
1answer
164 views

What can cause the bloating in high protein diet of Whey proteins?

I am thinking what can cause the swelling of gastrointestinal system i.e. bloating after high protein diet of Whey proteins. Liver does breaks those proteins to branched chain amino acids (BCAA), ...
1
vote
1answer
34 views

Mechanism of DNA gyrase inhibitor

Why DNA gyrase inhibitor, such as Nalidixic acid and Norfloxacin, do not stop gyrase from cutting DNA helix but only prevent them from decatenation replicating DNA?
1
vote
1answer
43 views

In what forms do plants and animals excrete sulfur?

Sulfur is part of the amino acids cystein and methionin, plants take up sulfur in the form of $H_2S$. These organisms will also need a way to get rid of excess sulfur, how? In what compounds? Judging ...
2
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2answers
38 views

Bohr effect in respiration

Would I be correct in saying that the Bohr effect is ONLY related to the concentration of [H+] in the tissues. Obviously the concentration of carbon-dioxide can contribute to this concentration by ...
5
votes
1answer
52 views

Equation for accurate prediction of PCR yield

It is a cliche of freshman biology labs to point out that "every cycle of PCR doubles the DNA, so the yield will be $2^{cycles}$ times the template amount". However, if this were true, 1 ng of ...
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0answers
36 views

Poly Unsaturated Fatty Acid

PUFAs spontaneously oxidize, speed up the process of glycation, since too much glucose and they also decrease mitochondrial respiration - more oxygen and CO2, less lactate and PUFA also promote ...
2
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1answer
38 views

naturally occuring fatty acids

The double bonds in naturally occurring fatty acids present in our body are in cis configuration while the enzymes for beta oxidation can act on trans double bond. Then what will be the significance ...
-1
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1answer
56 views

What organism most efficiently converts a given quantity of mass into heat?

Question I am trying to answer: In the popular film The Matrix, heat given off by humans is harvested as an energy source. I wondered, if this were possible, would humans be a good organism to ...
7
votes
1answer
64 views

Excretion of monovalent and divalent ions in sharks

I have heard that sharks excrete $\ce{Na+}$ and $\ce{Cl-}$ by their gill surfaces but divalent ions like magnesium are excreted through feces. What could be the reason behind this?
5
votes
1answer
52 views

Scale up of Bacterial growth from 250mL to 1-5L?

I am currently growing up a specific strain of E.Coli with a knockout in 40mL of growth medium (LB) in a 250mL shaker flask... My ultimate goal is to scale up this process to a 1-5L large scale setup ...
4
votes
1answer
45 views

How different are tissue-specific fibroblasts from each other?

I am planning to utilize a new system in our lab, in which I will co-culture cancer cells from different tissues with fibroblasts. I have the option to receive skin-derived primary fibroblasts. I ...
2
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0answers
25 views

Isoprene and Acrolein emissions of wood burning, insect burning and smoldering tobacco cigarette

I'd like to identify what makes a fume more or less toxic, above all those from commonly smoked organic stuff: tobacco, cannabis, comparatively to less common ones. For that, we can focus on 2 gas ...
2
votes
1answer
48 views

Mesoporous silica particles as anti cancer drug delivery method

If this question is a little off topic for Biology, I'm sorry. I've recently read a lot about mesoporous silica nanoparticles as a promising drug delivery method. The huge range of customizability of ...
3
votes
1answer
400 views

Why is funnel web spider venom so lethal to humans and not so much for other mammals?

According to the information from this article, People and other primates are exquisitely sensitive to funnel web venom but, intriguingly, other mammals such as mice, rabbits, guineapigs, dogs ...
8
votes
2answers
49 views

What are the ecological effects of moderately high and prolonged concentrations of nitrogen deposition on an ecosystem?

There are many sources of nitrogen which eventually get deposited out of the atmosphere and onto the land/surface. Typically higher levels of nitrogen compounds are emitted near urban and roadway ...
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4answers
64 views

Why is too much glucose harmful?

I learned the citric acid cycle in biotechnology school and how cells work; about ADP and ATP and how the Cellular respiration (C6H12O6 + 6O2 -> 6CO2+6H2O) works. I am interested in understanding why ...
0
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1answer
31 views

About molecules and their shape

When a molecule is being used in some biochemical process it has a certain 3-d structure. Is this maintained throughout it's usage or can one specific molecule change it's 3-d shape while it is being ...
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0answers
18 views

Can non-carbonated energy drinks boost alcohol intoxication?

I just read news article about banning caffeine in alcohol drinks and about that energy drinks increase the urge to drink alcohol. Energy drinks cause sugar intoxication - answer about it here ...
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0answers
50 views

amino acid containing branched side chain

Branched-chain amino acid are degraded by branched chain alpha-keto acid dehydrogenase complex. These amino acids aren't degraded in liver because of the absence of this enzyme(in liver).Why the ...
3
votes
1answer
20 views

bacterial cell wall degradation in humans

can human degrade the D-amino acid present in bacterial cell wall, I'm confused about it i have read somewhere that human can do so.If yes than why we need antibiotic to kill bacteria???If it is not ...
1
vote
2answers
61 views

Significance of synthesis of D-glucose in plants..?

why plants can only synthesize D-glucose why not L-glucose along with D glucose. I know it very well that plants have only enzymes which can synthesize D-glucose but Why not they have enzymes which ...
4
votes
2answers
130 views

Effect of testosterone hormone on cell signalling and behaviour?

A steroid, testosterone was injected in female body which led to development of secondary sexual characters but these characters were not developed over night (Response was very slow). What could be ...
0
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0answers
18 views

What chemical form of vitamin A is in chicken's egg yolk?

After doing some existing background research I am confused as to exactly what, in an unfertilised chicken egg's yolk, offers what we intake as 'Vitamin A' upon eating it. Plants typically produce ...
2
votes
2answers
64 views

How to determine whether the energy of a stem-loop fold is significant or not?

If I have a predicted RNA stem-loop of energy -0.30 kcal/mol, and another of -4.9 kcal/mol, how do I tell whether such a structure is a significantly stable structure or not? Our two competing ...
3
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0answers
87 views

Why doesn't honey spoil quickly? [duplicate]

Why is it that honey can last for decades and not spoil like other foods? Is there any chemical in honey which gives rise to this amazing feat?
2
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0answers
39 views

Does vinegar neutralize the strongly-basic compounds in cement? [migrated]

I have heard that washing one's hands with vinegar is effective in neutralizing the strong bases in cement and is more effective than water. I want to know how cement burns, and what bases are ...
3
votes
3answers
97 views

More entropy: Atom or Macromolecule? [closed]

A question that appeared on my last exam was : Which of the following has greater entropy A) An atom B) A macromolecule The question doesn't specify anything else(i.e. type/size of atom or ...
5
votes
2answers
264 views

Diffusion of Hypotonic solution into solution with glucose and starch

Cell walls are selectively permeable to ions and organic molecules. Sometimes the selectivity is passive and a reflection of the physical laws governing diffusion. We can do simple experiments that ...
49
votes
3answers
24k views

Why is uracil used in RNA rather than thymine?

What is the advantage gained by the substitution of thymine with uracil? I have read previously that it is due to thymine being "better protected" and therefore more suited to the storage role of ...
7
votes
1answer
119 views

Pharmacologically, can tricyclic antidepressants have a side-effect profile similar to neuroleptics?

Torticollis (wryneck, cervical dystonia) is a neurologic movement disorder causing involuntary muscle spasms in the neck. Often, neuroleptics can cause such a side effect. I'm wondering if this ...
3
votes
1answer
53 views

How to recognize a conserved motifs of the protein

I would like ensure that my reasoning is correct. Assuming that I know the aminoacids sequence of the protein of interest. I can't say anything about the structure looking only at the aminoacids ...
4
votes
1answer
85 views

Question about Monofunctional glycosylases

I am learning about Base excision repair mechanism. I understand the main idea how glycosylases are working, but I am trying to understand this with much more details. I found a paper where they are ...
32
votes
4answers
14k views

Death because of distilled water consumption

One of my friends said that I would die if I drank distilled water (we were using it in a chemistry experiment) I gave it a go and surprisingly did not die. I did a bit of Googling and found this ...
9
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2answers
288 views

Why does Hunger lead to the aggressive behavior?

I have observed that frequently when people are hungry; they tend to get angry more easily on pointless issues. Does this mean that our fight or flight response is more active when a person is hungry? ...
2
votes
1answer
20 views

Formation of peptide bond..?

Proteins peptide bond is made by condensation process in which a molecule of water is released and according to this process it is not favorable in water systems than how peptide bond is formed by ...
3
votes
1answer
100 views

Other than Acetylcarnitine what other orally-bioavailable Acetyl donors exist to assist in the conversion of CoA to acetyl-CoA?

I asked a question on bio stackexchange a few days from which I was hoping to be able to arrive at an answer for this question myself but I have had no such luck so now I am going to just ask ...
3
votes
3answers
703 views

Histidine aromaticity

I understand that the imidazole ring in histidine is aromatic. I also realize that it retains it's aromaticity when protonated. I am wondering why it is not mentioned at all in basic text books such ...
3
votes
2answers
78 views

Humidity for wood rotting

If I put a piece of wood in a humid environment (basically humid air), it will start to rot. Does the humidity influence the rotting speed, and if so, what is the relation between the rotting speed ...
1
vote
1answer
43 views

Measurement of glucose concentration in the human brain

If I want to measure the exact glucose concentration in a human brain then how can I proceed to do that? Is there any technique or assay to do that?
1
vote
1answer
69 views

How do a particular arrangement of atoms become self aware? [closed]

At the simplest level, we're all just atoms, animals, plants and humans alike. But what I don't understand, is how a particular arrangement of atoms such as us can become self aware, and be able to ...
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2answers
162 views

How much vanilla will kill a person?

I received a gift that is a jug of Pure Mexican Vanilla. Having never dealt with large quantities of vanilla, it made me curious as to what would happen if a person had too much vanilla. I understand ...