The use of methods from the physical sciences to aid in the study of biological systems.

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56 views

What is the transmembrane 'Positive-Inside Rule' nowadays? Has the definition changed over time?

First definition. Two publications by von Heijne in 1989 and 1992 coined the 'Positive-Inside rule' and showed it's practical value in topology prediction of transmembrane helices. It was clearly ...
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30 views

Infrared emitting diode eye safety

I'm thinking of creating my own laser tag system and am a bit concerned about the eye safety aspect. Most of the homebrew system I've seen use the TSAL 6100 ...
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63 views

What biological processes can affect the temperature of the shadow a tree casts?

Assuming two trees have similar shape and leaf coverage, could differences in the biological processes among them lead to differences in the temperature of the shadow they cast? What biological ...
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38 views

How to get a pdb file of a single atom?

I am trying to get a pdb file that contains a single atom, it doesn't matter if it's Hydrogen or another atom. How can I obtain this? Are there any pdb files with just a single atom available to ...
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12 views

Can Nanodiscs be used to study membrane energetics?

Nanodiscs have changed they way we can study the structures, insertion, and functions of transmembrane proteins. Below is an image of a nanodisc bilayer. The key difference, as far as I can tell, ...
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71 views

How can the directionality of a protein structure be defined?

For a DNA molecule, you can define directionality using the convention of a 5'-3' direction on the Sense strand. However, using an N to C convention for a protein doesn't work since the ends may be on ...
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22 views

What are some commonalities between biology systems and semiconductor physics?

It seems that fundamentally both neural system and semiconductors are operating using similar principles on the same scale. Things such as drift and diffusion current plays major role in both systems. ...
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47 views

Unexpected stoichiometry n in ITC experiments

I'm looking at the binding of a small molecule to several RNA constructs and tried to determine the binding constants. To do this I've performed a few ITC experiments on this system, the results were ...