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Calculating additive variance, heritability, and percent of variance explained by additive effects

I've set up some dummy data in R which makes 40 genetically related lines (in this case I'm simulating hemiclones - they share one haploid copy of there genome within a line, thus additive genetic ...
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Penetrance Calculation of a Spontaneous Mutation

I'm trying to estimate the penetrance of a disease in a population given a rare spontaneous mutation that confers predisposition in an autosomal dominant manner. Given that the mutation is ...