The tag has no wiki summary.

learn more… | top users | synonyms

9
votes
1answer
103 views

Is bootstrapping an acceptable way to determine standard error for binding constants?

I'm measuring binding constants my system and I appreciate the usual methods of using replicates to measure standard errors and using those errors to calculate propagation of error. I'm curious if ...
7
votes
3answers
6k views

Deciding between chi square and t test

I am always so confused whether to do a chi square test or a t test in the sums given by my biostats teacher. Does anyone have a simple rule to decide this?
6
votes
0answers
168 views

Additive genetic variance components from LMER in R

I've set up some dummy data in R which makes 40 genetically related lines, they are all siblings within a line so are genetically related by a factor of ½ thus additive genetic variance should be ...
5
votes
1answer
213 views

Are descriptive statistics sometimes more useful than tests of significance?

How does the biology community currently feel with regards to publishing descriptive and effect size statistics rather than significance stats? Almost every journal article I read in the cell biology ...
4
votes
1answer
105 views

Is there a correlation between incidence of type 1 diabetes and vitiligo?

Does the data indicate that if you have one, the probability of you having the other is higher than that of someone who doesn't have the one?
3
votes
1answer
44 views

Why genes are assumed to follow multivariate normal?

I wonder why gene expression data are very frequently modeled by multivariate normal distributions. What is the reason for those strong assumptions that the genes follow multivariate gaussian? Are ...
2
votes
1answer
34 views

Material on the analysis of (micro)array data

I'm at the moment analyzing cytokine array data. The available material on the statistical analysis of these data is more than unsatisfactory. Since a lot of effort is being made in the analysis of ...
2
votes
2answers
37 views

Choosing appropriate statistical test for ordinal data

Ordinal response variables show up often in biology, but I'm not sure how they are best analysed. Some examples are qualitative assessments (little, many, a lot) or risk assessments (low risk, medium ...
1
vote
2answers
146 views

On evolution statistics [closed]

This basic evolution theory question has been haunting me since childhood and I'm kind of embarrassed that I can't explain it yet: Consider a butterfly. It's wings have evolved to look like the eyes ...
1
vote
1answer
36 views

Local BLAST Copy Number per Hit

I generated a series of local BLAST databases using makeblastdb of metagenomic data and am searching for the presence of a particular gene. While I can do the normal BLAST analysis looking at ...
1
vote
1answer
278 views

How many (taxonomic) families are there?

Approximately, how many families have been identified? I've often often come across figures for the total number of species on Earth. Recently, I found myself wondering about the encompassing ranks ...
1
vote
1answer
98 views

Standardized Selection Ratio (SSR)

In this article the athors used the Standardized Selection Ratio (SSR) in order to infer what is the preferred host (anemone) of anemonefish. Here is a quotation coming from their methods: ...
1
vote
0answers
43 views

Penetrance Calculation of a Spontaneous Mutation [on hold]

I'm trying to estimate the penetrance of a disease in a population given a rare spontaneous mutation that confers predisposition in an autosomal dominant manner. Given that the mutation is ...
1
vote
1answer
72 views

Niche overlap Index

I wanted to use the compana() function from the adehabitat package. I don't really understand the meaning of the data in the ...
0
votes
1answer
102 views

Gene pool simulation [closed]

this simulation, you sampled the gene pool without replaceing beads in the beakerafter you drew each one. Thus, f(A) and f(a) in the gene pool changed slightly after each bead was drawn. For example, ...
0
votes
1answer
58 views

Needing help in order to infer the statistical hypothesis tests performed in an old paper

I am in great need of help in order to infer the statistical hypothesis tests performed in an old paper. However I need to make some reasonable guesses only from the abstract of the paper since the ...