A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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3answers
61 views

Can bioluminescence be used for cancer or tumor detection? [closed]

What diagnostic applications, if any, are there in using bioluminescence to detect cancer or tumors (in vivo)?
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0answers
31 views

Contact Inhibition of Cell Division: Signaling Pathway

The following article refers to contact inhibition of cell division in epithelial cells, specifically MDCK cells: Collective and single cell behavior in epithelial contact inhibition. In their review ...
5
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1answer
121 views

Telomerase as cancer target

There are a lot of publications, starting from 2000, about using telomerase for targeting cancer cells (it is upregulated in more than 80-90% of tumor cells). Specifically using its promoter (hTERT). ...
3
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1answer
88 views

What type of flask should I use to culture NTERA2 embryonic cancer stem cells?

I'm just starting my MSc research and I am in the process of making a list of equipments/consumables to order. Is there a specific flask in which I can culture NTERA2 (NTERA2/D1) cell line?
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1answer
21 views

What are the roles of cadherins in epithelial mesenchymal transitions? [closed]

I know that cadherins control the expression of cancer cells involved in the epithelial-mesenchymal transitions, but I was wondering exactly how the process worked.
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1answer
34 views

Enzyme\Protein amounts in cancer

I am searching for source, that providing information about enzymes\proteins, in different types of cancers, that their amount in cell is significantly higher - comparing to normal, healthy cell. ...
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1answer
23 views

Mitochondria variability per tissue in humans?

I would like to know the distribution of mitochondrial content per tissue type in humans. I understand the simple metric that energetically active or energy requiring tissues will have more ...
7
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1answer
71 views

Why do people with Down syndrome get fewer cancers?

I'm coming across some conflicting information regarding the correlation between cancer incidents and trisomy 21. I read a report from nature that discusses how Downs are only a tenth as likely to ...
0
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1answer
25 views

What sort of assay could be used to identify mutants with mutator phenotype? [closed]

By mutator phenotype, I mean being more prone to mutations, for example due to mutations in genes involved in DNA repair. I was thinking about exposing the cells to agents that damage DNA (uv light, ...
1
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2answers
49 views

Why mutations in genes involved in general processes like DNA repair increase the risk of developing specific types of cancer?

For example, mutation in MHS2, which encodes a protein involved in the repair of mismatches that occur during DNA replication, dramatically increases the risk of developing colon cancer. (There are ...
0
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0answers
16 views

How can I classify Breast Cancer if I have incomplete receptor information?

I have a clinical data table for a cohort of Breast Cancer patients and I want to classify them as being either triple negative or triple positive. You can find the file here. For some of the ...
0
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0answers
28 views

Where can I find mutation datasets for cancer (other than TCGA)?

My lab has been using TCGA data (somatic mutations and clinical data) to develop panels of genes and of mutations we expect to see in certain cancer populations. We'd like to validate our panels by ...
3
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1answer
41 views

Expression/Mechanism of ROR1 in healthy tissue

ROR1 is currently under investigation as a therapeutic target for cancer (1). A number of studies show different cancers may have their metastatic potential reduced, or become apoptotic through ...
8
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2answers
57 views

All UniprotIDs of a cancer pathway

I need to download all uniprotIDs of a cancer pathway, say the AKT Signaling. It may be super easy, but I don't know which resource to look at since it is a new field. How/where do I find these?
1
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1answer
35 views

Why is it important to study chromatin to understand cancer?

Many labs and many projects in biology institutes and university departments have been starting to study chromatin. Chromatin states, chromatin interactions, chromatin loopings, chromatin behaviours, ...
3
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1answer
51 views

What does it mean when a patient suffering from malignant tumor (cancer) has been declared cured?

Comment by Anongoodnurse, has made me curious as to what a doctor means when (s)he says "The cancer is cured" to a patient. My idea up till this point (based on what I read and what I learned in my ...
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2answers
70 views

What are the differences between a benign tumor and swelling?

What are the differences between a benign tumor and an injury related swelling? And can swellings due to injury turn into a benign tumor?
8
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1answer
606 views

Have there been studies done to test Immortality of Cancer Cells on culture?

The article here says cancer cells may be immortal. I am wondering if there has been any research done to find if cancer cells are really immortal. How old is the still maintained living oldest ...
1
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1answer
20 views

Why does a tumour's genome change depending on the environment?

According to the book "Primer of The Molecular Biology of Cancer" by Vincent, Theodore and Ateven, the tumour cell is changed depending on its environment. performed genome-wide analysis on three ...
6
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2answers
399 views

What are the differences between cancer and tumour?

What are the differences between cancer and tumour? I mean is it in the DNA or shape or something else... And how can a benign tumour turn into a malignant tumour? The body has a lot of tumours all ...
1
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1answer
34 views

The damage of cancer cells

I read about the molecular biology of cancer, and I have a mess on my head and a lot of questions.. . My primary question is- The damage of the cancer cells is in the dna sequence or in the gene ...
2
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1answer
79 views

Does increased cell turnover cause cancerous mutations?

If a certain set of cells or tissue are undergoing a lot of reproduction and repair cycles for some reason, does this inevitably lead to cancerous growths? If the mutation rate exceeds the normal ...
2
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1answer
48 views

Energy metabolism in Cancer cells

The TCA cycle intermediate Isocitrate dehydrogenase commonly undergoes point mutations in cancers. This allows IDH to reduce a-Ketogluterate to 2Hydoxygluterate, causing a reduction in pVHLs ability ...
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0answers
27 views

Superpatients for Cancer resistance

I was reading an article on MIT Technology review about superpatients for low cholesterol that got me thinking whether such patients exist for cancer. The article is ...
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1answer
44 views

About the apoptosis mechanisms in a cell

The apoptosis mechanisms in a cell are like a type of 'self-destruction mechanism': is this correct? As with any type of complex system with various necessary functions, if it has a set of ...
5
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1answer
31 views

About radiation therapy

With radiation therapy, could some of the radiation used cause new mutations in non-cancerous cells that are near the tumour that is being irradiated? If so could these new mutations lead to new ...
11
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2answers
177 views

Why should a tumor look like a crab?

Origin of the word cancer The disease was first called cancer by Greek physician Hippocrates (460-370 BC). He is considered the “Father of Medicine.” Hippocrates used the terms carcinos and ...
3
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1answer
28 views

Regarding tumors and their developement

If certain cells or tissue in a specific part of the body are for some reason overworked; like the cases of severe acid reflux damaging the throat repeatedly and the cells in the throat having to do ...
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0answers
36 views

Cigarette consumption dose-response function WRT health outcomes

I'm curious how health risks (mortality, lifetime probability of cancer, etc) change with cigarette consumption. Specifically, treatring cigarette consumption like a continuous variable, rather than ...
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1answer
91 views

Henrietta Lacks and HeLa cells

Why did Henrietta Lacks die when her cells didn't die? As I understand it only the cells from her cervix were immortal so perhaps the cervical cancer took her life and the cells never died.
2
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1answer
37 views

Regarding the apoptosis mechanisms in cells and cancer

If all the cells in a cancerous tumour had their apoptosis mechanisms 'turned back on' or reactivated or repaired by some 'yet to be discovered' process would this cause the tumour to 'self destruct' ...
0
votes
1answer
11 views

About artificially induced processes that would normally cause a cell to self-destruct

Are there certain biochemical processes that would normally cause a cell to self-destruct but if the cell being tested has apoptosis mechanisms that have malfunctioned or been 'turned off' the cell ...
2
votes
1answer
125 views

Is excessive hydration a risk factor for cancer in humans?

I was reading a book on radiation biology, and the book describes the process of "indirect action", where radiation can first ionize a water molecule forming a free radical, which then may interact ...
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0answers
18 views

Tumour resistance: single-cell or population effect?

Drug resistance can arise through a number of mechanisms. For instance, EGFR mutation when treating with EGFR inhibitors, or compensatory activation of alternative survival pathways. But does it occur ...
2
votes
1answer
38 views

Do metastatic cells still have their parent's identity?

If a liver cancer, for example, gives metastases. Will metastatic cells still have liver identity? I mean, if we mark liver cells, will we see the cancer cells too? Thanks a lot!
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0answers
31 views

Cells with no apoptosis mechanism and their 'byproducts'

If a culture or sample of cells is such they all have no apoptosis mechanisms yet they have not been at present determined to be cancerous ; given such a cell culture is there a way to determine by ...
0
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1answer
27 views

Could transfusion of a different blood type cure blood-based cancers?

Different antigen detection triggers an immune system response that could perhaps stimulate mitochondria and such in killing cancer cells - something like chemo without the hair-loss?
1
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0answers
27 views

Regarding benign tumors and what 'stops' them

Benign tumors can grow to dangerous size yet are they capable of metastisizing ; if not what stops this? Also with a benign tumor if you call its cells 'near' its edges its tumor 'cell wall' I was ...
3
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2answers
92 views

Can radiation equilevant to 1 CT (computer tomography) scan causes significant changes in human body?

I've read that CT scan causes radiation equivalent to few hundreds of ordinary X ray scan. It sound scary at the first look of it but I wonder is it the amount considered significant? Can dosage equal ...
3
votes
1answer
259 views

How does electrolarynx work?

I have heard that this is an effective replacement for patients who have a dysfunctional larynx, partly due to cancer. I am curious to know the inner working of this device and why such a robotic ...
3
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1answer
62 views

About sharks and how they find fish

Other than olfactory senses do sharks use some kind of sense that uses electromagnetic waves? Is this similar to an electric eel? I saw a book with the cover statement 'Sharks never get cancer'. IS ...
1
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1answer
45 views

About excessive cellular growth

When there is 'excessive' cell growth 'ordered' by the human body in some specific part of the body that is not part of the usual repairing mechanisms, does this cause extra telomere 'shortening' or ...
2
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2answers
101 views

Regarding cancer cells and telomeres

If cancer cells have telomeres are they different than the telomeres in non-cancerous cells? Would cancer cell telomeres be somehow 'set-up' to function almost indefinitely; in other words are 'they' ...
7
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3answers
1k views

How fast do cancer cells divide, compared to normal cells?

This question suggests that we have, on average, 50-70 billion cell divisions per day. I just read that cancer cells divide more often and are therefore more prone to radiation. I am wondering, for ...
5
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2answers
35 views

Regarding cellular self-destruction

I heard and read telomere 'health' or 'length' ( if that's right ) has alot to do with cell 'health'. If telomere 'abilities' are 'restored' to a 'healthier' status then the cell it is in functions as ...
0
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0answers
16 views

SRC & RSV virus origins

When a virus infects a cell it undergoes recombination with cell genome. I understand how recombination happens. So in the process, is a gene from virus delivered into human genome or human genome ...
4
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2answers
54 views

Are there known downsides to removing UV mutation hotspots to prevent some skin cancers (Genetic sunblock)?

Khavari et al. recently demonstrated that a significant fraction of one of the major forms of skin cancer (cutaneous squamous cell carcinomas) are associated with a mutated KNSTRN gene (a protein ...
0
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2answers
292 views

Does scratched Teflon coated frying pans contain carcinogens which can cause cancer? [closed]

Is it true that using scratched Teflon-coated pans contain carcinogens, and if so, can they be consumed through the food cooked in them? E.g. The deadly toxins from non-stick frying pans
2
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0answers
28 views

Subtypes of Acute myeloid leukemia

I am a computer scientist with no biological background and working on analyzing lab results of patients with Acute myeloid leukemia. They have been tagged with following subtypes of AML: AML with ...
0
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1answer
41 views

Regarding apoptosis and turning it 'back on'

Is there some chemical or chemicals or even special molecules that can be 'injected' into cancer cells that will turn any Apoptosis mechanisms 'back on'? Or maybe chemicals and/or molecules that ...