A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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The mechanism of cancer metastasis

Generally, EMT, Epithelial to Mesenchymal Transition is thought to be involved in the mechanism in which cancer cells metastasize in the early stage. EMT is an process in which epithelial cells ...
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Non-malignant cells can still be cancerous?

Say that I am classifying melanoma tumor cells and want to determine of this population which are malignant and which aren't. From a genetic and transcriptional perspective, I could characterize these ...
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How is signalling disturbed in trophoblastic cancer cells?

Trophoblastic cancer seems to be a form of growth that no longer responds to the neural signals which try to inhibit them. Can someone please explain whether experiments have been performed as to how ...
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2answers
28 views

What amount of genes co-expressed should be expected in a tissue?

I am working with gene expression microarrays of tumor tissues and I want to use a program to find the clusters of co-expressed genes in order to know if some particular genes are co-expressed with ...
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Cancer biology: Can tumors form from cells that are genetically identical to non-cancerous cells?

Can a tumor begin to form without any genetic mutations? I'm specifically interested in a tumor which could later lead to cancer.
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What are extracellular matrix pathways?

I was reading a research paper dealing with acute myeloid leukemia and the term "extracellular matrix pathway" came up. What does it mean? I found literature on extracellular matrix, but I'm not sure ...
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Do Tumor-Infiltrating T Cells Experience Any Prolonged Effects Due To Hypoxia After They Return To Normoxia?

Adoptive cell transfer (ACT) therapy using tumor-inflitrating lymphocytes (TIL) is at the cutting edge of immuno-oncology treatments involving metastatic melanoma and other indications (1). The idea ...
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1answer
30 views

How do normal cell division chance into a tumor forming cell division? [closed]

Or its better to say what happens at molecular level that tumors are formed? I tried normal google search and google books but couldn't find any appropriate explanation. I am trying to understand why ...
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1answer
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How do cancers eventually lead to death / other debilitating symptoms? [closed]

With regards to people I know or have read about who live with cancer, most of their symptoms are results of chemotherapy, surgical interventions, etc., which have the goal of eradicating the cancer. ...
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18 views

Repeating assays assessing drug synergy by Chou and Talalay method

I have been using MTT cell viability assays to test compounds, both as single agents and in combination, in a constant ratio. From these assays I have been able to plot the median effect plot to get ...
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59 views

Why are sarcomas rare compared to carcinomas?

A sarcoma (from the Greek σάρξ sarx meaning "flesh") is a cancer that arises from transformed cells of mesenchymal origin. Thus, malignant tumors made of cancellous bone, cartilage, fat, muscle, ...
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1answer
30 views

Why is chronic lymphocytic leukemia (CLL) most common leukemia in the West but so rare in Asia?

In "Advances in Chronic Lymphocytic Leukemia" (2013, Edited by Sami Malek), several times it is stated that CLL is very common in Western countries. However, it is quite rare in Asia. (I do not have ...
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Where do I find the label, whether this file data corroborates to a healthy tissue or a cancerous one in TCGA data?

I downloaded the TCGA dataset for LUAD (Lung Cancer), I find each file with miRNA sequence data like readCount and parts per million value and their are around 123 samples. But where do I find the ...
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How can I apply any machine learning model/classifier on miRNA seq data?

I recently got micro RNA sequencing data from the TCGA. I am currently trying to early detect Mesothelioma. How is microRNA seq data different from microRNA expression data? MicroRNA expression ...
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1answer
114 views

Is metastatic cancer always lethal if uncured?

Can matastases spread in different parts of the body of an animal suffering from cancer grow in a limited way, such as not to cause much more harm that a benignant tumor in those parts of the body ...
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50 views

Has Staphylococcus aureus ever been used against cancer?

Treating inoperable tumors with bacteria appears to be very effective, albeit being toxic to the patient as well. Has (live attenuated) Staphylococcus aureus ever been used against cancer? If the ...
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22 views

What the gene variation detection result can tell us about a cancer [duplicate]

We do a research on a particular cancer, now we have a result of the gene variation detection . What next steps do we need to do? we don't have a clear picture about this. Can you give us some ...
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1answer
101 views

Why does fever above 102 herald a cancer patient's death?

I was recently intrigued by the observation of a longtime hospice nurse that her cancer patients die a different death than her Alzheimer's or multiple sclerosis or heart failure or COPD patients. ...
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Can anyone help me find some information on cytotoxic activities of lymphoma cells

It is known that lymphoma cells express various cytotoxic molecules, such as granzymes and perforin. However, I cannot find any papers concerning the cytotoxic activity of lymphoma cells, rather than ...
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26 views

Can lymphoma cells perform the functions that normal lymphocytes do?

It is known that lymphoma cells are derived from lymphocytes such as T cells, B cells, and even natural killer cells (arguably). Can these lymphoma cells attack microbes, viruses, or secrete ...
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1answer
24 views

Measuring tumor heterogeneity [closed]

I would like to ask if there's any method (established or not) in order to quantify heterogeneity found in mutations occuring in primary neoplasms and metastatic lesions (either common or private) and ...
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0answers
38 views

How to construct tumor phylogenetic tree?

I would like to know if anyone has tried any software that constructs tumor evolution trees where the trunks represent the common mutations and the private alterations are noted on each branch. I can ...
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21 views

Tumor cell image database

Could anyone recommend a database of circulating cancer cells (CTC) images? I am working on an algorithm to distinguish them from red blood cells.
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TCGA Array Data Interpretation - why is PTEN up when I know it shouldn't be in RCC?

I am trying to make some sense of the KIRC (clear cell renal cell carcinoma) gene expression microarray data (level 3). I am a little bit confused by the expression levels of PTEN which are elevated ...
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79 views

Does cancer cells come from same process as evolution? [duplicate]

Here is how I understand it: DNA replication is not 100% perfect and error can happen, this error can be good(evolution) or bad(cancer properties). But its not the only source of cancer cells - DNA ...
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1answer
87 views

Why do we have oncogenes? [closed]

Oncogene is a gene which in certain circumstances can transform a cell into a tumour cell. Everything we have has reason and meaning. Or there was some use in past. What's the reason for we have ...
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2answers
79 views

How to predict the effect of a non coding SNP variant on the expressed protein?

I am writing a paper for non coding SNPs on patients with metastatic breast cancer. Having used a specific gene panel (NGS) of approximately 60 genes, I'm currently running out of ideas on what to ...
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28 views

How accurate are proteomic-based biomarkers of cancer? [closed]

Currently protein expression is one of the widely used biomarker types. For example, any $i^{th}$ protein could be a selected biomarker. How can a minute change in single protein concentration ($m/...
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1answer
39 views

How do CD 8+ Tc cells reach the site of tumors?

In normal humoral immunity, dendritic cells present antigens to the Th cells by arriving at the Lymph node. This is fine. But consider a tumor cell. How does the Tc cell sitting in the lymph node know ...
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The properties of benign tumours

Do benign tumours have no functioning apoptosis mechanisms ? If so what stops benign tumours from excessive growth? Also can a benign tumour have a functioning apoptosis mechanism?
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Pathogenesis of Cardiac Atypia?

I am studying the pathogenesis of atypia in cardiac cells where the etiology is most commonly irritation or infection and where the precancerous risk depends on the context of diagnosis. This fact ...
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1answer
42 views

Why is mRNA used as a biomarker for cancer over tRNA or rRNA?

I cannot find a clear explanation for why mRNA is used as cancer biomarker and not tRNA or rRNA. Is there something peculiar about mRNA which cannot be fulfilled by tRNA or rRNA?
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1answer
134 views

Can bacteria, viruses, and cancer cells be destroyed by resonance?

Radiotherapy has been used to treat cancer. Can the resonances by coordinated electromagnetic waves (and/or other forms of waves), of various frequencies, amplitudes and pulse rates, directed from ...
2
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1answer
39 views

Is there some research paper which focus on the influence of using cancer cell as experimental materials on experimental result? [closed]

Cancer cell is unstable cell and high variation, but there are many experiment use cancer cell as experimental materials. I always wonder how much influence can using cancer cell as experimental ...
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Why lactate inhibits growth (or enhances death rate)?

Extracellular lactate tends to inhibit cellular growth or enhance cell death. This happens in the vicinity of tumors and in cell cultures. See for example this reference: Ozturk, Sadettin S., Mark R....
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Escaping resource limitations during tumor evolution

In their discussion of the importance of r- and K-selection on tumors, Aktipis et al. (2013; figure 3) provide the following illustration of a hypothetical cancer growth curve: In it, you can see ...
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1answer
25 views

Where does the lactate produced by tumors go?

Tumors are known to burn glucose and secrete lactate (this is known as the Warburg effect). Where does this lactate go? Does it steadily accumulate in the neighborhood of the tumor? This doesn't ...
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3answers
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In a tumor, why hypoxic regions have access to glucose?

The Warburg effect is ubiquitous in cancer. It consists of the upregulation of glucose uptake, glycolysis, and subsequent lactate secretion, sometimes by over 200 times, in cancer cells as compared to ...
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1answer
45 views

Whales and cancer [duplicate]

Do whales get less cancer than they should considering they have a lot more cells and tissue? If a lot of cancer formation is random because of mutations then shouldn't whales receive a lot of ...
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2answers
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Do antioxidants interfere with chemotherapy?

Since most of the chemotherapy drugs kill cancer cells by damaging their DNAs by means of free radicals. So antioxidants, which will detoxify free radicals, should theoretically decrease the efficacy ...
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0answers
22 views

Probabilities of gene amplification: four questions [closed]

Do mutations in the SLC1A5 gene affect tumor proliferation? Are SLC1A5 mutations in tumors dominant, recessive, or neutral? Amplification vs mutation vs overexpression: please explain the difference....
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25 views

What are the determinants of tumor metastasis

Under what conditions do tumors migrate? Is it due to hostile microenvironment conditions, drug application, mutations, or other causes? Are there any migration probability values (I am doing an in ...
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44 views

On ways to treat cancer [closed]

If an area that has tumours is affected by some non-lethal disease would it kill the cancer cells first since the tumour cells are more 'unstable' ? Could this non-lethal disease 'process' be ...
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1answer
29 views

Numbers in the names of tumor markers

In tumor markers such as CA 125, CA 19-9 and many other, CA stands for Carcinoma antigen, but what about the number?
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69 views

Where do I find microsatellite instability annotation for TCGA data

I have searched through the TCGA data portal but I was unable to find MSI annotation for TCGA Colon Adenocarcinoma (COAD) and Rectum Adenocarcinoma (READ) datasets. I am searching for the annotation ...
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0answers
31 views

Can Allergy and Auto-immune diseases be the signs of hyper-vigilant immune system?

Allergy sufferers are much less likely to get some types of cancers. Theories regarding allergy - cancer link are mixed. Many say it is due to hyper-sensitive immune response. But the correlation ...
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1answer
60 views

Is it possible to have cancer and normal blood count at the same time? [closed]

Does cancer always cause abnormal full blood count? I've read on the internet that some people who had advanced cancer, also had normal blood count. I can't find anything on the internet about this ...
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2answers
55 views

Cancer cells and their ability to avoid the immune system

Since cancer cell retain their ability to trigger the immune system from their pre-cancerous state and any condition that causes an auto-immune reaction in a specific area of the body will attack any ...
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0answers
104 views

Why do leukemia and lymphoma cause “night sweats”?

One of the symptoms of these blood cancers is sleep hyperhidrosis (aka night sweats). Also referred to as one of the B-symptoms, it may be used for prognosis. What is the the mechanism behind the ...
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Immunotherapy for tumours which do not have TSA

Is immunotherapy possible for tumours which do not have Tumour Specific Antigens (TSA)? If so, doesn't targeting those tumour cells also target other healthy cells, thus causing autoimmunity ?