1
vote
0answers
20 views

Segregation Analysis for predicting age-specific cancer risk

I am relatively new to the world of genetics research and have been tasked with presenting to my lab the potential value of a paper that uses Complex Segregation Analysis for a risk analysis. The hope ...
2
votes
2answers
37 views

Functioning of BRCA2

I know that BRCA2 interacts with RAD51 to repair DNA damage. But how exactly does it function ? What are the other proteins that interact with it ?
1
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0answers
44 views

Best way to automatically link Gene Entrez ID with Gene Symbol in TCGA

I am trying to figure out how to link Gene Entrez ID with Gene Symbol, for TCGA dataset. So far, I have found this ftp directory with Gene info updated daily. But, for Entrez ID 728661, I have found ...
2
votes
2answers
53 views

Connection between genes and pathways

I am reading about a paper about inferencing pathway information in cancer cells. Authors refer to ERBB2 as a gene and a pathway. I don't have solid biology background. What exactly means when we ...
0
votes
1answer
123 views

How can synonymous mutations lead to cancerous or tumorous phenotypes?

After analyzing DNA sequences of an oncogene from many human cancer patients, you found that synonymous substitutions occur in a specific codon of this oncogene. Assuming that these synonymous ...
2
votes
2answers
95 views

How does smoking, an environmental factor, cause cancer, fundamentally a genetic disease?

If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking cause cancer?
4
votes
1answer
71 views

Transcriptionally-mediated DNA damage

I'm researching the genetics of brain cancer, and finding a huge number of mutations in voltage-gated channels. It stands to reason that some of this DNA damage is due to the DNA being transcribed ...