A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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Deciding a reasonable threshold for copy number variation in a CNV (SNP array) TCGA dataset

Is there a methodology to select a reasonable threshold for copy number variation in a CNV (SNP array) TCGA dataset, to define when there is a significative alteration? Can I download CNV data for ...
5
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2answers
51 views

Why is cisplatin a very potent antineoplastic for testicular cancer, but not necessarily for other cancers?

Cisplatin (structure below) is a platinum-based chemotherapeutic agent which is very effective in the treatment of some cancers. Its introduction was responsible for improving the cure rate for ...
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0answers
25 views

Cell Line With DNMT3a Mutation

I am looking for a cell line (preferably hematopoietic) that has an inactivating DNMT3a mutation. I have checked the Cancer Cell Line Encyclopedia but of all the hematopoietic cell lines I know I ...
5
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2answers
634 views

Breeding laboratory mice with cancer; how does this work?

It has recently been brought to my attention that live laboratory mice with specific cancer strains can be readily purchased for medical research. For example, the Jackson Laboratory sells mice with ...
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2answers
71 views

Can you Transfer Cancer Between People via Saliva or other Bodily Fluids?

This may sound like a strange question. But could a Cancerous cell be transferred from one person to another from Oral contact e.g. Through Saliva, or other exchange of bodily fluids? I know that ...
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3answers
92 views

Can we knock out Caspase-9 *and* avoid breast cancer phenotype in our mouse model?

I am trying to design a wet lab experiment with no wet lab experience to name. Right now, in my dream land, it would be excellent if it were possible to create a Caspase-9 knockout mouse (damage to ...
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1answer
46 views

GATK workflow for Cancer

I am just starting to learn to use bioinformatics tools. My university has a limited and expensive bioinformatics team, so I'm mostly on my own except for big questions. I am planning to use GATK to ...
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0answers
26 views

Can photosyntetic cells be genetically modified to grow at a faster rate?

I hope the question is not silly, but I wonder if a sort of genetically modified plant "cancer" could be used for carbon sequestration. For example, cancer cells like HeLa have been reproduced in ...
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3answers
36 views

Doxorubicin's intercalant and topoisomerase inhibition in leukemia?

I am thinking the role of doxorubicin's pathways in cancers such as leukemia and lymphoma: topoisomerase inhibitor and inhibit DNA activity intercalant - intercalant DNA bases and inhibit DNA ...
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1answer
15 views

What's a segmented copy number profile

I am studying copy-number variation. I am reading C. H. Mermel, S. E. Schumacher, B. Hill, M. L. Meyerson, R. Beroukhim, and G. Getz, “GISTIC2.0 facilitates sensitive and confident localization ...
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1answer
60 views

How can electric fields inhibit tumor growth?

In MIT's Technology review it is explained that electric fields can cause dividing cancer cells to explode, while these fields have no significant impact on non-dividing tissues. The original research ...
5
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1answer
41 views

How can the phenotypic effects of a tumor suppressor mutation be silenced?

I've been reading a little about the "two-hit" hypothesis for tumor suppressor genes here, which mentions that some genes exhibiting haploinsufficiency are exceptions to the hypothesis. I've read ...
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1answer
30 views

Why do epithelial cells arrest in response to serum?

Primary epithelial cells, for example human mammary epithelium, fail to proliferate (arrest) in serum-containing medium. Therefore, a common growth medium for epithelium contains pituitary extract ...
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2answers
398 views

Looking for a cancer drug target database to guide sequencing of patient tumor DNA

I have a question I would like to pose to the community. I have recently received access to a bench-top ion torrent DNA sequencer. Our idea is to use this machine to sequence the DNA from patient’s ...
4
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2answers
58 views

Classify chemotherapy drugs?

I'm studying a TCGA dataset trying to find correlations between gene expression and clinical data which might shed light on some pathways. One column of the clinical data provides a list of ...
3
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1answer
25 views

What is the most reliable tumour suppressing gene for NSCLC?

I was looking at some tumour suppressing genes that can be helpful in diagnosing lung cancer (particularly NSCLC - Non-small-cell lung carcinoma) at an early stage. I came across a few such as p53, ...
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1answer
52 views

Does homeopathic or herbal treatment of cancer have any scientific recognition?

Even though we have a very high tech society, cancer is still a serious issue. We humans still are not entirely capable of fighting cancer. Radiation and chemotherapy are still considered the best ...
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2answers
53 views

What are multicell spheroids?

I'm from a maths background and I'm doing some research on mathematical models of cancer. I've come across alot of literature mentioning "multicell spheroids" in the context of avascular tumours. I ...
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1answer
59 views

Why is it important to study chromatin to understand cancer?

Many labs and many projects in biology institutes and university departments have been starting to study chromatin. Chromatin states, chromatin interactions, chromatin loopings, chromatin behaviours, ...
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1answer
632 views

Have there been studies done to test Immortality of cancer cells in culture?

This website on cultured cancer cells () says cancer cells may be immortal. I am wondering if there has been any research done to find if cancer cells are really immortal. How old is the still ...
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1answer
32 views

How is cancer associated with host pathogen interaction?

Does cancer by any chance fall under host pathogen interaction domain? What I mean to ask is that, is there pathogen interaction involved in cancer? I went through this article: ...
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1answer
32 views

How does cancer of the larynx (laryngeal cancer) affect the respiratory system?

The larynx is part of the respiratory system and is responsible for producing sound (our voices). My question is how cancer in the larynx (voice box) affect the respiratory system overall? I ...
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0answers
45 views

Why is chemotherapy so expensive? [closed]

I have two questions related to the price of chemotherapy: I was told it was expensive, but was not able to put numbers on it. Where could I find information regarding the actual price of a given ...
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2answers
23 views

Difference between taking tissue of cancer from secondary place or primary place

Are there any differences when a surgeon takes tissue from secondary place (for example from metastasis) rather then from primary place (from an organ where cancer is) for morphological research?
3
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1answer
87 views

About sharks and how they find fish

Other than olfactory senses do sharks use some kind of sense that uses electromagnetic waves? Is this similar to an electric eel? I saw a book with the cover statement 'Sharks never get cancer'. IS ...
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0answers
62 views

Where can I find mutation datasets for cancer (other than TCGA)?

My lab has been using TCGA data (somatic mutations and clinical data) to develop panels of genes and of mutations we expect to see in certain cancer populations. We'd like to validate our panels by ...
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0answers
111 views

Best way to automatically link Gene Entrez ID with Gene Symbol in TCGA

I am trying to figure out how to link Gene Entrez ID with Gene Symbol, for TCGA dataset. So far, I have found this ftp directory with Gene info updated daily. But, for Entrez ID 728661, I have found ...
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2answers
686 views

TCGA gene expression data are missing matched normal

I'm trying to use the TCGA data portal to get gene expression data for cancer tissues, but I'm not sure what "Tumor matched normal" means. It is unclear to me if the values are already compared to a ...
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40 views

Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
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2answers
213 views

Could cancer be in itself a evolutionary process?

Could cancer be in itself a evolutionary process? Maybe in some way could it be a process of variation? Or would this idea be completely without support, if so, why? I don't mean that each case ...
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1answer
33 views

How to tell if a given gene is a tumor suppressor or oncogene?

This is a problem taken from "Concepts of Genetics", Klug et al, 10e. I'm given the following table about the mutations in the BRCA1 gene: $$\begin{array}{c|c|c|c|c} ...
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2answers
77 views

Difficulties understanding a pathway [closed]

I am not a biologist and I would love to understand what is going on with this pathway. I went to the description but it's still complicated, and I couldn't follow. Can someone please help me with it? ...
3
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3answers
70 views

Can bioluminescence be used for cancer or tumor detection? [closed]

What diagnostic applications, if any, are there in using bioluminescence to detect cancer or tumors (in vivo)?
2
votes
1answer
54 views

Energy metabolism in Cancer cells

The TCA cycle intermediate Isocitrate dehydrogenase commonly undergoes point mutations in cancers. This allows IDH to reduce a-Ketogluterate to 2Hydoxygluterate, causing a reduction in pVHLs ability ...
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78 views

Contact Inhibition of Cell Division: Signaling Pathway

The following article refers to contact inhibition of cell division in epithelial cells, specifically MDCK cells: Collective and single cell behavior in epithelial contact inhibition. In their review ...
3
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1answer
60 views

Expression/Mechanism of ROR1 in healthy tissue

ROR1 is currently under investigation as a therapeutic target for cancer (1). A number of studies show different cancers may have their metastatic potential reduced, or become apoptotic through ...
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3answers
2k views

How fast do cancer cells divide, compared to normal cells?

This question suggests that we have, on average, 50-70 billion cell divisions per day. I just read that cancer cells divide more often and are therefore more prone to radiation. I am wondering, for ...
2
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1answer
199 views

Are cell lines potentially dangerous?

More specifically, if a human subject was exposed to, say, a human cancerous cell line (via intravenous injection or through an open wound, for example), is it possible that they would develop any ...
5
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1answer
132 views

Telomerase as cancer target

There are a lot of publications, starting from 2000, about using telomerase for targeting cancer cells (it is upregulated in more than 80-90% of tumor cells). Specifically using its promoter (hTERT). ...
3
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1answer
101 views

What type of flask should I use to culture NTERA2 embryonic cancer stem cells?

I'm just starting my MSc research and I am in the process of making a list of equipments/consumables to order. Is there a specific flask in which I can culture NTERA2 (NTERA2/D1) cell line?
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2answers
732 views

Are all mutagens carcinogens?

Not all carcinogens are mutagens. Alcohol and estrogen, for example, does not damage DNA. It's one of the assumptions of the Ames test that mutagenicity implies carcinogenicity, but is this always ...
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1answer
25 views

What are the roles of cadherins in epithelial mesenchymal transitions? [closed]

I know that cadherins control the expression of cancer cells involved in the epithelial-mesenchymal transitions, but I was wondering exactly how the process worked.
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1answer
38 views

Enzyme\Protein amounts in cancer

I am searching for source, that providing information about enzymes\proteins, in different types of cancers, that their amount in cell is significantly higher - comparing to normal, healthy cell. ...
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1answer
28 views

Mitochondria variability per tissue in humans?

I would like to know the distribution of mitochondrial content per tissue type in humans. I understand the simple metric that energetically active or energy requiring tissues will have more ...
10
votes
1answer
101 views

Why do people with Down syndrome get fewer cancers?

I'm coming across some conflicting information regarding the correlation between cancer incidents and trisomy 21. I read a report from nature that discusses how Downs are only a tenth as likely to ...
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2answers
57 views

Why mutations in genes involved in general processes like DNA repair increase the risk of developing specific types of cancer?

For example, mutation in MHS2, which encodes a protein involved in the repair of mismatches that occur during DNA replication, dramatically increases the risk of developing colon cancer. (There are ...
0
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1answer
27 views

What sort of assay could be used to identify mutants with mutator phenotype? [closed]

By mutator phenotype, I mean being more prone to mutations, for example due to mutations in genes involved in DNA repair. I was thinking about exposing the cells to agents that damage DNA (uv light, ...
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2answers
186 views

In cancer, why do cells duplicate themselves?

In regards to cancer why do cells replicate themselves? If it's a mutation, what kind of mutation would this be classified as?
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0answers
21 views

How can I classify Breast Cancer if I have incomplete receptor information?

I have a clinical data table for a cohort of Breast Cancer patients and I want to classify them as being either triple negative or triple positive. You can find the file here. For some of the ...
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2answers
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All UniprotIDs of a cancer pathway

I need to download all uniprotIDs of a cancer pathway, say the AKT Signaling. It may be super easy, but I don't know which resource to look at since it is a new field. How/where do I find these?