A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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68 views

Expression/Mechanism of ROR1 in healthy tissue

ROR1 is currently under investigation as a therapeutic target for cancer (1). A number of studies show different cancers may have their metastatic potential reduced, or become apoptotic through ...
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3answers
3k views

How fast do cancer cells divide, compared to normal cells?

This question suggests that we have, on average, 50-70 billion cell divisions per day. I just read that cancer cells divide more often and are therefore more prone to radiation. I am wondering, for ...
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1answer
238 views

Are cell lines potentially dangerous?

More specifically, if a human subject was exposed to, say, a human cancerous cell line (via intravenous injection or through an open wound, for example), is it possible that they would develop any ...
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1answer
136 views

Telomerase as cancer target

There are a lot of publications, starting from 2000, about using telomerase for targeting cancer cells (it is upregulated in more than 80-90% of tumor cells). Specifically using its promoter (hTERT). ...
3
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1answer
107 views

What type of flask should I use to culture NTERA2 embryonic cancer stem cells?

I'm just starting my MSc research and I am in the process of making a list of equipments/consumables to order. Is there a specific flask in which I can culture NTERA2 (NTERA2/D1) cell line?
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2answers
832 views

Are all mutagens carcinogens?

Not all carcinogens are mutagens. Alcohol and estrogen, for example, does not damage DNA. It's one of the assumptions of the Ames test that mutagenicity implies carcinogenicity, but is this always ...
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1answer
30 views

What are the roles of cadherins in epithelial mesenchymal transitions? [closed]

I know that cadherins control the expression of cancer cells involved in the epithelial-mesenchymal transitions, but I was wondering exactly how the process worked.
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1answer
38 views

Enzyme\Protein amounts in cancer

I am searching for source, that providing information about enzymes\proteins, in different types of cancers, that their amount in cell is significantly higher - comparing to normal, healthy cell. ...
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1answer
33 views

Mitochondria variability per tissue in humans?

I would like to know the distribution of mitochondrial content per tissue type in humans. I understand the simple metric that energetically active or energy requiring tissues will have more ...
10
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1answer
116 views

Why do people with Down syndrome get fewer cancers?

I'm coming across some conflicting information regarding the correlation between cancer incidents and trisomy 21. I read a report from nature that discusses how Downs are only a tenth as likely to ...
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2answers
59 views

Why mutations in genes involved in general processes like DNA repair increase the risk of developing specific types of cancer?

For example, mutation in MHS2, which encodes a protein involved in the repair of mismatches that occur during DNA replication, dramatically increases the risk of developing colon cancer. (There are ...
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1answer
28 views

What sort of assay could be used to identify mutants with mutator phenotype? [closed]

By mutator phenotype, I mean being more prone to mutations, for example due to mutations in genes involved in DNA repair. I was thinking about exposing the cells to agents that damage DNA (uv light, ...
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2answers
196 views

In cancer, why do cells duplicate themselves?

In regards to cancer why do cells replicate themselves? If it's a mutation, what kind of mutation would this be classified as?
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0answers
21 views

How can I classify Breast Cancer if I have incomplete receptor information?

I have a clinical data table for a cohort of Breast Cancer patients and I want to classify them as being either triple negative or triple positive. You can find the file here. For some of the ...
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2answers
60 views

All UniprotIDs of a cancer pathway

I need to download all uniprotIDs of a cancer pathway, say the AKT Signaling. It may be super easy, but I don't know which resource to look at since it is a new field. How/where do I find these?
2
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1answer
122 views

Does increased cell turnover cause cancerous mutations?

If a certain set of cells or tissue are undergoing a lot of reproduction and repair cycles for some reason, does this inevitably lead to cancerous growths? If the mutation rate exceeds the normal ...
3
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1answer
103 views

What does it mean when a patient suffering from malignant tumor (cancer) has been declared cured?

Comment by Anongoodnurse, has made me curious as to what a doctor means when (s)he says "The cancer is cured" to a patient. My idea up till this point (based on what I read and what I learned in my ...
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2answers
161 views

What are the differences between a benign tumor and swelling?

What are the differences between a benign tumor and an injury related swelling? And can swellings due to injury turn into a benign tumor?
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1answer
32 views

Why does a tumour's genome change depending on the environment?

According to the book "Primer of The Molecular Biology of Cancer" by Vincent, Theodore and Ateven, the tumour cell is changed depending on its environment. performed genome-wide analysis on three ...
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1answer
70 views

Why is sarcoma more prevalent and common in right heart?

Ewing's sarcoma or Ewing sarcoma is a malignant small, round, blue cell tumor. It is a rare disease in which cancer cells are found in the bone or in soft tissue. It is more common in right heart than ...
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1answer
38 views

The damage of cancer cells

I read about the molecular biology of cancer, and I have a mess on my head and a lot of questions.. . My primary question is- The damage of the cancer cells is in the dna sequence or in the gene ...
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1answer
12 views

About artificially induced processes that would normally cause a cell to self-destruct

Are there certain biochemical processes that would normally cause a cell to self-destruct but if the cell being tested has apoptosis mechanisms that have malfunctioned or been 'turned off' the cell ...
3
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1answer
61 views

How is the growth of benign tumors suppressed?

A benign tumor has an outer layer of cancerous cells beyond which are regular cells (I Think). The Tumor must have some kind of boundary layer like a wall where somehow the cancerous cells can't ...
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0answers
34 views

Superpatients for Cancer resistance

I was reading an article on MIT Technology review about superpatients for low cholesterol that got me thinking whether such patients exist for cancer. The article is ...
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1answer
47 views

About the apoptosis mechanisms in a cell

The apoptosis mechanisms in a cell are like a type of 'self-destruction mechanism': is this correct? As with any type of complex system with various necessary functions, if it has a set of ...
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1answer
49 views

About radiation therapy

With radiation therapy, could some of the radiation used cause new mutations in non-cancerous cells that are near the tumour that is being irradiated? If so could these new mutations lead to new ...
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2answers
320 views

Why should a tumor look like a crab?

Origin of the word cancer The disease was first called cancer by Greek physician Hippocrates (460-370 BC). He is considered the “Father of Medicine.” Hippocrates used the terms carcinos and ...
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4answers
136 views

Can a tumor produce something not currently found in our own bodies?

While speaking with my co-workers, the topic of tumors growing things came up. The examples were (and backed by images) of tumors growing a tooth, hair, and sometimes even more complex objects such ...
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1answer
30 views

Regarding tumors and their developement

If certain cells or tissue in a specific part of the body are for some reason overworked; like the cases of severe acid reflux damaging the throat repeatedly and the cells in the throat having to do ...
5
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2answers
41 views

Regarding cellular self-destruction

I heard and read telomere 'health' or 'length' ( if that's right ) has alot to do with cell 'health'. If telomere 'abilities' are 'restored' to a 'healthier' status then the cell it is in functions as ...
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0answers
47 views

Cigarette consumption dose-response function WRT health outcomes

I'm curious how health risks (mortality, lifetime probability of cancer, etc) change with cigarette consumption. Specifically, treatring cigarette consumption like a continuous variable, rather than ...
2
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1answer
117 views

Are there any examples where 'magic bullet' drugs have worked in cancer treatment?

Magic bullets are drugs that can be administered on a micro local scale. In this context administration/binding would occur in or near the tumour by exploiting the different surface antigens that ...
3
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1answer
36 views

How to make sure a stem cell culture is cancer free?

Say I take a blood sample from an adult, extract the white cells and apply to them the process described in <this article>. Assuming this actually turns the adult white cells into stem cells, which ...
0
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1answer
116 views

Henrietta Lacks and HeLa cells

Why did Henrietta Lacks die when her cells didn't die? As I understand it only the cells from her cervix were immortal so perhaps the cervical cancer took her life and the cells never died.
2
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1answer
40 views

Regarding the apoptosis mechanisms in cells and cancer

If all the cells in a cancerous tumour had their apoptosis mechanisms 'turned back on' or reactivated or repaired by some 'yet to be discovered' process would this cause the tumour to 'self destruct' ...
2
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1answer
130 views

Is excessive hydration a risk factor for cancer in humans?

I was reading a book on radiation biology, and the book describes the process of "indirect action", where radiation can first ionize a water molecule forming a free radical, which then may interact ...
2
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2answers
107 views

Regarding cancer cells and telomeres

If cancer cells have telomeres are they different than the telomeres in non-cancerous cells? Would cancer cell telomeres be somehow 'set-up' to function almost indefinitely; in other words are 'they' ...
2
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1answer
39 views

Do metastatic cells still have their parent's identity?

If a liver cancer, for example, gives metastases. Will metastatic cells still have liver identity? I mean, if we mark liver cells, will we see the cancer cells too? Thanks a lot!
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0answers
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Tumour resistance: single-cell or population effect?

Drug resistance can arise through a number of mechanisms. For instance, EGFR mutation when treating with EGFR inhibitors, or compensatory activation of alternative survival pathways. But does it occur ...
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0answers
34 views

Cells with no apoptosis mechanism and their 'byproducts'

If a culture or sample of cells is such they all have no apoptosis mechanisms yet they have not been at present determined to be cancerous ; given such a cell culture is there a way to determine by ...
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1answer
29 views

Could transfusion of a different blood type cure blood-based cancers?

Different antigen detection triggers an immune system response that could perhaps stimulate mitochondria and such in killing cancer cells - something like chemo without the hair-loss?
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0answers
34 views

Regarding benign tumors and what 'stops' them

Benign tumors can grow to dangerous size yet are they capable of metastisizing ; if not what stops this? Also with a benign tumor if you call its cells 'near' its edges its tumor 'cell wall' I was ...
3
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2answers
151 views

Can radiation equilevant to 1 CT (computer tomography) scan causes significant changes in human body?

I've read that CT scan causes radiation equivalent to few hundreds of ordinary X ray scan. It sound scary at the first look of it but I wonder is it the amount considered significant? Can dosage equal ...
3
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1answer
599 views

How does electrolarynx work?

I have heard that this is an effective replacement for patients who have a dysfunctional larynx, partly due to cancer. I am curious to know the inner working of this device and why such a robotic ...
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1answer
68 views

About excessive cellular growth

When there is 'excessive' cell growth 'ordered' by the human body in some specific part of the body that is not part of the usual repairing mechanisms, does this cause extra telomere 'shortening' or ...
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0answers
16 views

SRC & RSV virus origins

When a virus infects a cell it undergoes recombination with cell genome. I understand how recombination happens. So in the process, is a gene from virus delivered into human genome or human genome ...
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2answers
64 views

Are there known downsides to removing UV mutation hotspots to prevent some skin cancers (Genetic sunblock)?

Khavari et al. recently demonstrated that a significant fraction of one of the major forms of skin cancer (cutaneous squamous cell carcinomas) are associated with a mutated KNSTRN gene (a protein ...
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2answers
557 views

Does scratched Teflon coated frying pans contain carcinogens which can cause cancer? [closed]

Is it true that using scratched Teflon-coated pans contain carcinogens, and if so, can they be consumed through the food cooked in them? E.g. The deadly toxins from non-stick frying pans
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0answers
30 views

Subtypes of Acute myeloid leukemia

I am a computer scientist with no biological background and working on analyzing lab results of patients with Acute myeloid leukemia. They have been tagged with following subtypes of AML: AML with ...
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1answer
199 views

which signalling pathway is involved in cancer?

Columnar epithelial cells from the colonic mucosa are studied to identify abnormalities in cell signaling pathways. Abnormal epithelial cells from colonic adenocarcinoma are shown to have a mutation ...