A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

learn more… | top users | synonyms

3
votes
1answer
61 views

About sharks and how they find fish

Other than olfactory senses do sharks use some kind of sense that uses electromagnetic waves? Is this similar to an electric eel? I saw a book with the cover statement 'Sharks never get cancer'. IS ...
1
vote
1answer
45 views

About excessive cellular growth

When there is 'excessive' cell growth 'ordered' by the human body in some specific part of the body that is not part of the usual repairing mechanisms, does this cause extra telomere 'shortening' or ...
0
votes
0answers
16 views

SRC & RSV virus origins

When a virus infects a cell it undergoes recombination with cell genome. I understand how recombination happens. So in the process, is a gene from virus delivered into human genome or human genome ...
4
votes
2answers
54 views

Are there known downsides to removing UV mutation hotspots to prevent some skin cancers (Genetic sunblock)?

Khavari et al. recently demonstrated that a significant fraction of one of the major forms of skin cancer (cutaneous squamous cell carcinomas) are associated with a mutated KNSTRN gene (a protein ...
0
votes
2answers
289 views

Does scratched Teflon coated frying pans contain carcinogens which can cause cancer? [closed]

Is it true that using scratched Teflon-coated pans contain carcinogens, and if so, can they be consumed through the food cooked in them? E.g. The deadly toxins from non-stick frying pans
2
votes
0answers
28 views

Subtypes of Acute myeloid leukemia

I am a computer scientist with no biological background and working on analyzing lab results of patients with Acute myeloid leukemia. They have been tagged with following subtypes of AML: AML with ...
4
votes
1answer
153 views

which signalling pathway is involved in cancer?

Columnar epithelial cells from the colonic mucosa are studied to identify abnormalities in cell signaling pathways. Abnormal epithelial cells from colonic adenocarcinoma are shown to have a mutation ...
0
votes
1answer
41 views

Regarding apoptosis and turning it 'back on'

Is there some chemical or chemicals or even special molecules that can be 'injected' into cancer cells that will turn any Apoptosis mechanisms 'back on'? Or maybe chemicals and/or molecules that ...
1
vote
1answer
27 views

Regarding cancer cells and radio-frequency ablation

Are cancer cells destabilized if near a strong electromagnetic field over a long period of time? I read this technique of using radio-frequency ablation and heat shock to kill cancer cells. I don't ...
1
vote
2answers
82 views

Cancer cure statistics questions

I have a question about cancer cure statistics. Many of the cancer literature or databases I have come across speak about 5 year or 10 year survival rates. In this case survival means that the patient ...
3
votes
1answer
31 views

Regarding apoptosis and inhibitors

If there is an apoptosis shut-off mechanism of any kind, one could call it a null-apoptosis mechanism. If this is possible, could there be a null-apoptosis inhibitor? Something that inhibits an ...
2
votes
1answer
36 views

Classify chemotherapy drugs?

I'm studying a TCGA dataset trying to find correlations between gene expression and clinical data which might shed light on some pathways. One column of the clinical data provides a list of ...
1
vote
1answer
115 views

Carcinogens, how do they work?

The easiest carcinogenic thing for me to grasp is radiation, as it directly messes with DNA. Then it seems there are other compounds that simply mimic hormones, but these shouldn't necessarily cause ...
1
vote
1answer
454 views

What are garlic's effects on DHT?

Most antiandrogens inhibit DHT. DHT is connected to testosterone. [1] shows a beneficial effect on prostate cancer which can be caused by DHT. However, according to [2] garlic also increases ...
1
vote
1answer
56 views

What does “tumour budding” mean?

tumour budding, lymphocytic infiltration and resection margins are established factors that influence the outcome of colorectal cancer (1) In this context what does "tumour budding" mean? Reference ...
3
votes
2answers
84 views

Cancer growth and cell division [closed]

I am confused about the prerequisites for cell division and cancer. Which of the following is necessary for the cell cycle to progress? Hormones Growth factor Cyclins Cyclin dependent kinases ...
13
votes
3answers
374 views

Can plants get cancer?

I can't think of any reason why plants wouldn't be able to get cancer, but I've never heard of a plant growing a tumor. I've also never seen a plant with a noticeable abnormal growth. Can plants get ...
1
vote
1answer
82 views

What is a phospho-protein binding domain?

Is this just a domain that binds proteins that have been phosphorylated? And it mediates signalling between an activated/phosphorylated protein? How is this significant with BRCA1?
1
vote
2answers
526 views

TCGA gene expression data are missing matched normal

I'm trying to use the TCGA data portal to get gene expression data for cancer tissues, but I'm not sure what "Tumor matched normal" means. It is unclear to me if the values are already compared to a ...
2
votes
3answers
280 views

Why cancer mutations do accumulate sequentially?

According to Knudson hypothesis, cancer mutations accumulate in order. Statistics says, that cancer probability increases as sixth order of age, which may mean six consequential steps to cancer. But, ...
2
votes
1answer
33 views

Evolutionary rationale behind migration proteins

Tumor cells are able to migrate due to specific migration proteins. What is their evolutionary origin? Or are they simply deregulated?
0
votes
0answers
18 views

About the Heart and cancer [duplicate]

I read cancerous growth in the heart is rare . Why is that? Cancer cells are very unstable yet can function somehow. Could the Heart's intense pulses of electromagnetic energy make it alot harder for ...
1
vote
1answer
38 views

Is it firmly established, that mutations are sufficient for cancer?

It is evident for scientists, that all cancer cells have some mutated genes. Say mutations in general. But this evidence means necessary condition. But what about sufficient conditions? Is it ...
7
votes
2answers
217 views

Can oncogenesis happen without apoptosis pathway being affected?

Has there ever been incidences of one or more cancerous cells having all it's cell-death pathways and apoptosis mechanisms intact and functional?
2
votes
1answer
57 views

About stem cells and Cancer

Do stem cells have an apoptosis mechanism and , if they do could this be used to repair the cell self-destruction pathways in a cancer cell?
1
vote
1answer
65 views

Could the Warburg effect be used to starve cancer cells in situ?

What is wrong with the following chain of reasoning? Nearly all cancer cells rely on high rates of glucose uptake (upto 200 times more than normal cells). This is known as the the Warburg effect. ...
1
vote
1answer
62 views

Do cell walls prevent cancer?

To my knowledge plants do not have an uncontrolled growth disease similar to cancer. Is the function by which they avoid uncontrolled growth related to their cell wall and preventing damage to ...
1
vote
2answers
66 views

In what ways can mechanisms of apoptosis be damaged?

How many ways can an Apoptosis mechanism be made disfunctional or irreparably damaged? If a cell has damaged Apoptosis mechanisms and it divides will its daughter cells have such damage?
1
vote
2answers
24 views

Concerning Apoptosis

What if cellular growth and repair is 'forced' to occur repeatedly in a region where it wouldn't normally happen , if the biological area was 'healthier'. Could this more aggressive cellular growth ...
4
votes
1answer
92 views

Do cancer cells give off specific chemical signatures?

Do cancer cells give off specific chemical signatures? Are these signatures different from normal cells?
1
vote
1answer
36 views

If a gene altered causes cancer and creates a protein for cancer can the new protein be isolated in some way?

In the above title question, can the protein thats altered not be isolated (to separate out from other proteins) somehow? Is there nothing that can bind to the specific cancer proteins that will not ...
1
vote
2answers
78 views

Epithelial cells and Rhinovirus

If you injected a tumor with epithelial cells infected with the Rhinovirus, would this still evoke an immune response as it would with the respiratory system? Secondly, what is the specific reason the ...
4
votes
2answers
143 views

Is solving cancer required in order to avoid aging?

When the telomerase enzyme is not active the telomere shortens every time the cell duplicates leading to a reproductive limit (Hayflicks limit). On one hand this is a believed reason for aging. On the ...
2
votes
2answers
51 views

Functioning of BRCA2

I know that BRCA2 interacts with RAD51 to repair DNA damage. But how exactly does it function ? What are the other proteins that interact with it ?
4
votes
2answers
93 views

Is there a standard reference for the importance of tumor heterogeneity?

In a recent post, Philip Gerlee highlighted the two biggest contributions of mathematical oncology to cancer research: (1) increasing focus on the progress of cancer as an evolutionary process, and ...
-3
votes
1answer
78 views

Can cancer be an immune system disorder? [closed]

Can cancer result from a weakened immune system? Would this mean that cancer could be considered an immune system disorder?
0
votes
1answer
38 views

Why do doctors do chemo or transplantation for cancers that don't respond well to these treatments? [closed]

From the UpToDate article on multiple myeloma: In most people, chemotherapy partially controls multiple myeloma; rarely, chemotherapy leads to complete remission. Also: Transplantation, ...
12
votes
2answers
209 views

Why do most breast cancers occur in women?

According to Korde et al. (2010): Male breast cancer accounts for less than 1% of all cancers in men and less than 1% of breast cancers. This raises the question: Why do most breast cancers ...
1
vote
2answers
115 views

Smoking, cancer, correlation between quitting smoking and increased immediate risk

There is "proof" out there today that suggests smoking is directly linked to cancer. I cannot argue against that, for the evidence in favor appears strong, and the evidence against is lacking. I'll ...
1
vote
0answers
79 views

Best way to automatically link Gene Entrez ID with Gene Symbol in TCGA

I am trying to figure out how to link Gene Entrez ID with Gene Symbol, for TCGA dataset. So far, I have found this ftp directory with Gene info updated daily. But, for Entrez ID 728661, I have found ...
1
vote
1answer
73 views

Is the Andraka pancreatic cancer test real?

In the wikipedia article about Andraka's pancreatic cancer test there are some controversial statements. On one hand there are many glorious words about the method, also some awards, also some ...
1
vote
1answer
43 views

At what cancer stage do tumors release circulating tumor cells into the blood?

And would a very accurate sensitive system for detecting circulating tumor cells (which detects 1 cell per 50 billion) be useful as a screening tool ?
3
votes
2answers
72 views

Detecting cancer or a genetic predisposition based on DNA sequencing

I am not by any means a biologist - so go easy. What would be a method for determining whether or not a patient has cancer based only on a genomic sequence? Update Thanks for the help in revising ...
2
votes
2answers
58 views

Connection between genes and pathways

I am reading about a paper about inferencing pathway information in cancer cells. Authors refer to ERBB2 as a gene and a pathway. I don't have solid biology background. What exactly means when we ...
4
votes
1answer
54 views

Where can I find histograms and tables of prevalence of mutations in cancer?

At some point in the past I found a cancer portal site which had aggregated data for the relationships between various mutations and their prevalence in cancer types and tumor data. The data was ...
0
votes
1answer
25 views

Different level of toxicity between smoke

Has there been studies on the difference between the smoke generated from: cigarette or cigar manufactured by brands which are proven to contain more than a hundred of dangerous additional ...
4
votes
1answer
73 views

Transcriptionally-mediated DNA damage

I'm researching the genetics of brain cancer, and finding a huge number of mutations in voltage-gated channels. It stands to reason that some of this DNA damage is due to the DNA being transcribed ...
0
votes
1answer
65 views

How does Acetaldehyde accelerate mitosis?

I read that one of the ways alcohol is carcinogenic is via accelerated mitosis due to acetaldehyde, I was wondering what pathway caused this acceleration?
1
vote
1answer
162 views

Why are haploid cancer cells not killed by immune system?

I have seen haploid cancer cells (I think it was leukemia cells) in a lab. Sperms and eggs are haploid but are not destroyed by the body because they are protected by other cells surrounding them. ...
0
votes
1answer
174 views

How can synonymous mutations lead to cancerous or tumorous phenotypes?

After analyzing DNA sequences of an oncogene from many human cancer patients, you found that synonymous substitutions occur in a specific codon of this oncogene. Assuming that these synonymous ...