A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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Different level of toxicity between smoke

Has there been studies on the difference between the smoke generated from: cigarette or cigar manufactured by brands which are proven to contain more than a hundred of dangerous additional ...
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1answer
89 views

Carcinogens, how do they work?

The easiest carcinogenic thing for me to grasp is radiation, as it directly messes with DNA. Then it seems there are other compounds that simply mimic hormones, but these shouldn't necessarily cause ...
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1answer
40 views

How does Acetaldehyde accelerate mitosis?

I read that one of the ways alcohol is carcinogenic is via accelerated mitosis due to acetaldehyde, I was wondering what pathway caused this acceleration?
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125 views

How can synonymous mutations lead to cancerous or tumorous phenotypes?

After analyzing DNA sequences of an oncogene from many human cancer patients, you found that synonymous substitutions occur in a specific codon of this oncogene. Assuming that these synonymous ...
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1answer
117 views

Why are haploid cancer cells not killed by immune system?

I have seen haploid cancer cells (I think it was leukemia cells) in a lab. Sperms and eggs are haploid but are not destroyed by the body because they are protected by other cells surrounding them. ...
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99 views

Can cancer cells in the same person, organ, and origin have different DNA?

Is it possible for cells from the same tumor to have different genetic material, and if so, to what degree is it possible (how fast do they mutate) ?
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70 views

What is a phospho-protein binding domain?

Is this just a domain that binds proteins that have been phosphorylated? And it mediates signalling between an activated/phosphorylated protein? How is this significant with BRCA1?
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1answer
16 views

Cancer history on environment-cancer relationship

I am interested to know how environment-cancer relationship knowledge has developed. I know that all began when Muller first proved that mutation could be induced via ionizing radiation, X rays in the ...
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2answers
130 views

Is solving cancer required in order to avoid aging?

When the telomerase enzyme is not active the telomere shortens every time the cell duplicates leading to a reproductive limit (Hayflicks limit). On one hand this is a believed reason for aging. On the ...
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2answers
98 views

How does smoking, an environmental factor, cause cancer, fundamentally a genetic disease?

If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking cause cancer?
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1answer
201 views

Are there any types of cancer that cause neurons to divide?

After birth neurons generally do not divide. But is there any specific type of rare cancer or tumour where neurons divide? And if there is such a cancer, then how is it possible for a neuron to regain ...
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0answers
67 views

A number of questions regarding chemotaxis assay using PBMCs

In our lab we would like to study the chemotaxis of PBMCs towards conditioned medium obtained following treatment of cancer cells with different compounds. My questions are regarding the method of ...
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1answer
342 views

Extremely rare occurence of Heart cancer?

The occurrence of Heart cancer (similar, but not the same as Rhabdomyosarcoma) is extremely rare, about 1 per year according to MayoClinic. The reason for this rarity is explained to be the ...
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34 views

How is oral cancer development and turnover rate of oral epithelium related

How is oral cancer development and turnover rate of oral epithelium related? Does their inverse relationship have genetic evidence?
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61 views

The role of antibodies interacting with cancer

I'm learning about antibodies. As I understand it, antibodies detect stranger cells/bacterial/viruses by the molecules present in their membranes. In cancer cells, the cancer cell have produce some ...
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2answers
139 views

Could cancer be in itself a evolutionary process?

Could cancer be in itself a evolutionary process? Maybe in some way could it be a process of variation? Or would this idea be completely without support, if so, why? I don't mean that each case ...
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1answer
71 views

Transcriptionally-mediated DNA damage

I'm researching the genetics of brain cancer, and finding a huge number of mutations in voltage-gated channels. It stands to reason that some of this DNA damage is due to the DNA being transcribed ...
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0answers
57 views

Are there any examples where 'magic bullet' drugs have worked?

Magic bullets are drugs that can be administered on a micro local scale near the tumour by exploiting the different surface antigens that cancers expose. The drug attaches via an mAb (attached to the ...
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1answer
51 views

What does “tumour budding” mean?

tumour budding, lymphocytic infiltration and resection margins are established factors that influence the outcome of colorectal cancer (1) In this context what does "tumour budding" mean? Reference ...
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1answer
1k views

How do liver and lung metastases cause death?

Metastasis to the liver and lungs are the main causes of death in colorectal cancer.(1) I understand that colorectal cancer may have metastases. But how do these metastases cause death? Reference ...
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1answer
49 views

What does “rapamycin-sensitive oncogenic transformation” mean?

Can someone explain exactly what "rapamycin-sensitive oncogenic transformation" is? I get that it's a drug that suppresses the immune system but what does it have to do with oncogenic transformation? ...
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1answer
143 views

By what mechanism is Streptococcus bovis acting as a risk factor for colorectal cancer?

Streptococcus bovis bacteremia/endocarditis is considered a risk factor for colorectal cancer. What pathophysiological mechanism may link the two together?
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1answer
760 views

Why is Sanger sequencing inferior for detecting SNPs in cancer cells?

I am familiar with Sanger sequencing, but at the level of an undergraduate. A lecturer of mine tried to describe Sanger sequencing as losing the sequence information in noise when used to detect ...
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1answer
407 views

Breeding laboratory mice with cancer; how does this work?

It has recently been brought to my attention that live laboratory mice with specific cancer strains can be readily purchased for medical research. For example, the Jackson Laboratory sells mice with ...
2
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1answer
68 views

Why it is so difficult to treat leukemia?

I want to ask what is the reason that T315I type CML leukemia is currently untreatable. I have read quite a few papers in this subject. Why the current genetic oriented engineering drugs failed to ...
2
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1answer
119 views

EGFR, sialylation, and cancer progression

EGFR (epidermal growth factor receptor) has been intensively studied in cancer and treatments have been developed to inhibit EGFR signaling. Sialylation of EGFR is known to block dimerization and ...
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1answer
32 views

How Common are Paraneoplastic Syndromes in Cancer Patients?

I recall reading around one in four cancer patients will suffer a paraneoplastic syndrome during the course of their illness but I can't find where I read this and I can't find any reliable sources to ...
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2answers
70 views

What is a “tool strain”?

When a biologist is talking about a genetically engineered mouse strain which is a "tool strain", what does that mean? What is the exact definition of a tool strain? What is the difference between a ...
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3answers
278 views

Can plants get cancer?

I can't think of any reason why plants wouldn't be able to get cancer, but I've never heard of a plant growing a tumor. I've also never seen a plant with a noticeable abnormal growth. Can plants get ...
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1answer
393 views

How does Topoisomerase II inhibition affect cancer cells?

Topoisomerase II poisons represent some of the most important and widely prescribed anticancer drugs currently in clinical use. These drugs encompass a diverse group of natural and synthetic ...
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2answers
41 views

Studying changes in DNA for causes of cancer

First of all let me say that I'm not into Biology myself... but I have a question for those of you who are. From what I've read, cancer is caused by 'faulty' DNA that behaves abnormally. Mutations ...
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1answer
26 views

Do Fatty Acid Synthase Inhibitors Selectively induce Apoptosis in Cancer cells without inducing the same in healthy human cells?

Do Fatty Acid Synthase (FAS) Inhibitors (e.g. cerulenin) selectively induce apoptosis in cancer cells without inducing the same in healthy human cells?
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3answers
105 views

Can a tumor produce something not currently found in our own bodies?

While speaking with my co-workers, the topic of tumors growing things came up. The examples were (and backed by images) of tumors growing a tooth, hair, and sometimes even more complex objects such ...
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1answer
79 views

What are the biological mechanisms behind the increase in cancer risk and alcohol consumption?

Alcohol consumption is known to be a risk factor for developing cancer. Compared to obvious causes like tobacco where one is exposed to known carcinogens, I don't see an obvious mechanism by which ...
2
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1answer
31 views

What range of dose should be used?

This is a dose-response experiment testing a new cancer drug. the darker line represents cancer cells. what range of dose should be used? I think it's 2-4 because this affects cancer cells only. is ...
4
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1answer
167 views

Why do we think chronic inflammation can cause cancer?

Why do we think chronic inflammation can cause cancer? I know the pathway is not fully understood, but what makes scientists believe that inflammation causes cancer?
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1answer
328 views

How can the Ames test detect a human carcinogen?

Using the Ames test, we add a mutagen to auxotrophic salmonella with mutations in the histidine pathway and rat liver extract to simulate metabolism. How would we know if the carcinogen is a human ...
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1answer
237 views

Can cancer grow forever if supplied with unlimited resources?

If somehow a human could give a tumor unlimited resources, would the cancer grow forever? It seems like it would until it gets so large that it physically affects vital organs. Is what would likely ...
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1answer
94 views

Which cells will pass cancer to offspring?

Each of these types below contains a DNA mutation. Which type(s) will affect the children of the individual whose cell it is. Red blood cell T cell Skin (epithelial) cell Neuron from the brain Sperm ...
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2answers
197 views

Why do most breast cancers occur in women?

According to Korde et al. (2010): Male breast cancer accounts for less than 1% of all cancers in men and less than 1% of breast cancers. This raises the question: Why do most breast cancers ...
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1answer
77 views

What causes mutations in regulatory genes? [closed]

In detail, what causes mutations in regulatory genes?
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1answer
118 views

In cancer, why do cells duplicate themselves?

In regards to cancer why do cells replicate themselves? If it's a mutation, what kind of mutation would this be classified as?
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5answers
286 views

What is the lowest common denominator of cancer?

What is the lowest level attribute that all cancers share? Also, what is the highest level attributes that all cancers share?
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1answer
52 views

Where can I find histograms and tables of prevalence of mutations in cancer?

At some point in the past I found a cancer portal site which had aggregated data for the relationships between various mutations and their prevalence in cancer types and tumor data. The data was ...
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2answers
184 views

Do both TSG and Proto-oncogenes have to suffer mutations to cause cancer?

I'm having a conceptual nightmare trying to understand when a group of cells may become cancerous and the more resources I consult the more confused I seem to get. In order for a cell to become ...
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1answer
295 views

How similar are Circulating Tumor Cells and Cancer Stem Cells?

Circulating Tumor Cells (CTCs) are linked with metastasis and their presence can be used to indicate the onset of metastatic cancer. Likewise, the Cancer Stem Cell (CSC) hypothesis suggests that ...
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1answer
93 views

Why doesn't yearly screening for lung cancer decrease mortality rates?

In a large trial, screening yearly for lung cancer hasn't reduced mortality rates. Why is this? Isn't cancer best treatable when caught early? Is this because lung cancer is hard to treat anyway, ...
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3answers
141 views

Robotic surgery for treating cancer?

We can localise cancer cells in the body. We can manufacture materials thin and hard enough to penetrate the body without harming it. So what stops us from creating an automated surgery where the ...
8
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1answer
466 views

Do larger multicellular organisms have an increased risk of mutation and thus cancer?

So I was thinking that if each cell has P(X) of becoming cancerous, then the chance of cancer is 1-((1-P(X))^n) where n is the number of cells in the organism. Since larger organisms have more cells ...
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1answer
358 views

Looking for a cancer drug target database to guide sequencing of patient tumor DNA

I have a question I would like to pose to the community. I have recently received access to a bench-top ion torrent DNA sequencer. Our idea is to use this machine to sequence the DNA from patient’s ...