A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

learn more… | top users | synonyms (1)

1
vote
1answer
44 views

Why is Bcl2 a good target for cancer therapy?

Bcl2 is a family of proteins that are involved in the inhibition of apoptosis in cells. My question is that what makes this anti-apoptotic protein useful in cancer therapies as opposed to focusing on ...
3
votes
1answer
52 views

Natural Killer Cell and Cancer

NK cells are very effective in destroying circulating cancer cells before their extravasation into the organ, However they have only a minimal inhibiting effect on already established micrometastases. ...
-1
votes
2answers
40 views

How is curcumin effective in fighting cancer?

Can you explain the mechanisms of how curcumin affects cancer cells and how effective it is? More reading: http://www.ncbi.nlm.nih.gov/pubmed/25667441 http://link.springer.com/article/10.1208/s12248-...
3
votes
2answers
124 views

Question about proto-oncogenes and oncogenes?

My textbook says: Growth-promoting genes are called proto-oncogenes. Some can be changed into oncogenes by a point mutation that alters the ability of the proto-oncogene to be switched off. They ...
1
vote
3answers
77 views

Cancer a method for early Earth Evolution? [duplicate]

Something I have been wondering for a while is looking at cancer from an evolutionary standpoint. It's easy to conclude (from observations today) that cancer is something we would rather avoid. ...
0
votes
0answers
16 views

What will happen if an anaplastic/cancer cell is used in cloning?

Since anaplastic cells have high glycolytic ratio and replicative potential, if they are used as the somatic cell in a model of cloning(like dolly's mother's udder cell), what is likely to happen?
3
votes
3answers
237 views

Can/Have cancer cells be/been used in stem cell culture lines?

Since Cancer cells have unlimited growth potential, can they be induced towards totipotency and pluripotency? If so, can cancer cells be used in stem cell culture because of similar properties of ...
0
votes
1answer
113 views

What's the difference between tumor cells and host cells? [closed]

When you talk about cancer, is there a difference between tumor cells and host cells ? What is the role of immune cells ? in a nutshell ?
5
votes
1answer
77 views

Can radiation therapy cause cancer?

Radiation therapy is a very popular cancer treatment method. But can it have any risk for make a different cancer? Because i think that radiation exposure can make DNA mutation and thus increase the ...
1
vote
0answers
53 views

Can a cell completely lose the ability to undergo apoptosis?

What I mean is - can a super-cancer cell completely lose the ability to kill itself, losing all apoptosis-related mechanisms and becoming eternally resistant to any drug that tries to induce apoptosis ...
3
votes
1answer
149 views

Why are cancer rates low in large animals?

Large animals generally have more cells and live longer than smaller animals. For example, bowhead whales live up to 200 years and weigh up to 100 tonnes, as opposed to humans (living ~71 years and ...
0
votes
1answer
44 views

How can rapid growth cancer get nutrients in vivo?

When I was little, before I get into biological studying, I read a news talking about cancer would be totally cured after decades. I still remember that researchers had a theory to claim if they could ...
1
vote
0answers
64 views

Absorbed dose from a CT scan with relation to radiation accidents

I read somewhere that the average CTDIvol in CT scans at hospitals is ~40 mGy. This translates to the 'radiation intensity' at the center of the person, and can also be roughly interpreted as an '...
0
votes
0answers
27 views

Effect of cellular phone towers on human health

We live in world of mobiles, tablets, PCs and other electronic gadgets. We are continuously exposed to radio frequencies and other cellular frequencies. Generally these all waves are with very low ...
1
vote
1answer
23 views

Ways to identify that proteins are regulating different genes experimentally

As part of my study I have been given this hypothesis: HIF 1a and HIF 2a regulate different genes in multiple myeloma What ways do we have to identify that these proteins are regulating ...
1
vote
1answer
106 views

How to find a Cancer PPI network data [closed]

I need a Protein Protein Interactions network of Cancer (any type - just I want a PPI of any type cancer), I search and see DIP PPI and .... How to specify that is Cancer PPI and how to get a PPI of ...
3
votes
1answer
105 views

Difficulty in finding protein inhibition drugs

I was reading an article on a recent identification of a PARP-14 protein in cancer cells that is responsible for production of additional glucose which keeps cancer cells from dying, and that a PARP-...
3
votes
0answers
57 views

What are the sizes of the cells that make up human hair?

The question is in the title, but I'll explain why the question arose. I'm curious about the rates that various cells in the body divide, and have found various information relating to this, but ...
3
votes
2answers
57 views

Chemotherapy - Hair loss

Chemotherapy kills cancer cells by targeting rapidly growing cells. That is why patients are loosing hair as well. My question is, why chemo related hair loss is temporary ? The docs say it is ...
0
votes
1answer
140 views

Cancer in myogenic heart cells? [duplicate]

Why cancer does not occur in myogenic heart cells? Is there any special ability in heart cells to resist cancer ?
0
votes
0answers
14 views

Best articles on Rad51/Rad52

What are the best journal articles to read on Rad51/Rad52 in the context of homologous recombination and cancer?
4
votes
2answers
56 views

Is the sun's damage to skin sufficient to warrant protection anytime the average person goes outside or just for extended periods?

According to the American Academy of Dermatology website, Everyone needs sunscreen Sunscreen should be used every day if you will be outside. The sun emits harmful ultraviolet (UV) rays year round. ...
3
votes
1answer
47 views

Why would mutation rates increase in a tumour?

This article describes a tumour: Swanton found that even the primary tumour was surprisingly varied. He found 128 mutations among the various samples, but only a third of these were common to all ...
8
votes
2answers
231 views

If Tumors have lots of mutations in them how is it the immune system can't detect them?

If a cancerous tumor has a lot of mutations in them why can't the immune system detect them? If a person has cancer could this somehow alter the person's immune system so it doesn't function ...
0
votes
0answers
16 views

What is the best aCGH normalization procedure for hyper-ploid tumor samples?

I'm currently working on aCGH data of Triple Negative Breast Cancer patients xenografts and primary tumor samples. A substantial amount of my samples is highly aberrated which leads to offsets of the ...
0
votes
0answers
47 views

Endogenous PAF inhibitor in metastatic process (?)

When neoplastic cells cause a metastasis, they can create a protective coat of platelets that counterbalances immunitary response. My question is if the coat formed due to PAF can be undone by an ...
6
votes
1answer
184 views

Are low-intensity radio-waves carcinogenic?

A recent review article, Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation reached a surprising conclusion our analysis demonstrates that low-intensity RFR [...
1
vote
1answer
54 views

Why doesn't Manipulated Virus for Cancer Cure Work [closed]

I'm not a biologist but I have an idea for a cure for cancer and it is very simple and probably has flaws (if it worked it probrably wouldn't be a cure for all) or is not possible but ... I'm still ...
0
votes
1answer
122 views

What specific mutations can cause an apoptosis mechanism to malfunction?

What specific mutations can cause the apoptosis mechanisms in a cell to malfunction? Are any such mutations 'reversible' , somehow or are they generally permanent? what kind of mutations can happen ...
2
votes
1answer
134 views

Why does T-cell Cancer Therapy require a large tumor mutanome?

An article I read about Neuroblastoma states that the fact that Neuroblstoma has a small mutanome means that it is not viable to apply the classic T-cell immunotherapy. Why is this so? The article can ...
3
votes
2answers
141 views

Deciding a reasonable threshold for copy number variation in a CNV (SNP array) TCGA dataset

Is there a methodology to select a reasonable threshold for copy number variation in a CNV (SNP array) TCGA dataset, to define when there is a significative alteration? Can I download CNV data for ...
0
votes
0answers
90 views

Cell Line With DNMT3a Mutation

I am looking for a cell line (preferably hematopoietic) that has an inactivating DNMT3a mutation. I have checked the Cancer Cell Line Encyclopedia but of all the hematopoietic cell lines I know I can'...
1
vote
2answers
548 views

Can you Transfer Cancer Between People via Saliva or other Bodily Fluids?

This may sound like a strange question. But could a Cancerous cell be transferred from one person to another from Oral contact e.g. Through Saliva, or other exchange of bodily fluids? I know that ...
5
votes
2answers
140 views

Why is cisplatin a very potent antineoplastic for testicular cancer, but not necessarily for other cancers?

Cisplatin (structure below) is a platinum-based chemotherapeutic agent which is very effective in the treatment of some cancers. Its introduction was responsible for improving the cure rate for ...
2
votes
2answers
335 views

GATK workflow for Cancer

I am just starting to learn to use bioinformatics tools. My university has a limited and expensive bioinformatics team, so I'm mostly on my own except for big questions. I am planning to use GATK to ...
1
vote
0answers
31 views

Can photosyntetic cells be genetically modified to grow at a faster rate?

I hope the question is not silly, but I wonder if a sort of genetically modified plant "cancer" could be used for carbon sequestration. For example, cancer cells like HeLa have been reproduced in tons,...
3
votes
3answers
57 views

Doxorubicin's intercalant and topoisomerase inhibition in leukemia?

I am thinking the role of doxorubicin's pathways in cancers such as leukemia and lymphoma: topoisomerase inhibitor and inhibit DNA activity intercalant - intercalant DNA bases and inhibit DNA ...
4
votes
1answer
106 views

How can electric fields inhibit tumor growth?

In MIT's Technology review it is explained that electric fields can cause dividing cancer cells to explode, while these fields have no significant impact on non-dividing tissues. The original research ...
1
vote
1answer
35 views

What's a segmented copy number profile

I am studying copy-number variation. I am reading C. H. Mermel, S. E. Schumacher, B. Hill, M. L. Meyerson, R. Beroukhim, and G. Getz, “GISTIC2.0 facilitates sensitive and confident localization ...
6
votes
2answers
55 views

Why do epithelial cells arrest in response to serum?

Primary epithelial cells, for example human mammary epithelium, fail to proliferate (arrest) in serum-containing medium. Therefore, a common growth medium for epithelium contains pituitary extract ...
1
vote
1answer
107 views

Does homeopathic or herbal treatment of cancer have any scientific recognition?

Even though we have a very high tech society, cancer is still a serious issue. We humans still are not entirely capable of fighting cancer. Radiation and chemotherapy are still considered the best ...
2
votes
2answers
313 views

What are multicell spheroids?

I'm from a maths background and I'm doing some research on mathematical models of cancer. I've come across alot of literature mentioning "multicell spheroids" in the context of avascular tumours. I ...
1
vote
1answer
100 views

How is cancer associated with host pathogen interaction?

Does cancer by any chance fall under host pathogen interaction domain? What I mean to ask is that, is there pathogen interaction involved in cancer? I went through this article: http://en.wikipedia....
0
votes
1answer
80 views

How does cancer of the larynx (laryngeal cancer) affect the respiratory system?

The larynx is part of the respiratory system and is responsible for producing sound (our voices). My question is how cancer in the larynx (voice box) affect the respiratory system overall? I ...
1
vote
0answers
102 views

Why is chemotherapy so expensive? [closed]

I have two questions related to the price of chemotherapy: I was told it was expensive, but was not able to put numbers on it. Where could I find information regarding the actual price of a given ...
1
vote
2answers
31 views

Difference between taking tissue of cancer from secondary place or primary place

Are there any differences when a surgeon takes tissue from secondary place (for example from metastasis) rather then from primary place (from an organ where cancer is) for morphological research?
4
votes
0answers
57 views

Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
2
votes
1answer
50 views

What is the most reliable tumour suppressing gene for NSCLC?

I was looking at some tumour suppressing genes that can be helpful in diagnosing lung cancer (particularly NSCLC - Non-small-cell lung carcinoma) at an early stage. I came across a few such as p53, ...
5
votes
3answers
188 views

Can we knock out Caspase-9 *and* avoid breast cancer phenotype in our mouse model?

I am trying to design a wet lab experiment with no wet lab experience to name. Right now, in my dream land, it would be excellent if it were possible to create a Caspase-9 knockout mouse (damage to ...
5
votes
1answer
49 views

How can the phenotypic effects of a tumor suppressor mutation be silenced?

I've been reading a little about the "two-hit" hypothesis for tumor suppressor genes here, which mentions that some genes exhibiting haploinsufficiency are exceptions to the hypothesis. I've read ...