A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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Regarding cancer cells and telomeres

If cancer cells have telomeres are they different than the telomeres in non-cancerous cells? Would cancer cell telomeres be somehow 'set-up' to function almost indefinitely; in other words are 'they' ...
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3answers
258 views

Why cancer mutations do accumulate sequentially?

According to Knudson hypothesis, cancer mutations accumulate in order. Statistics says, that cancer probability increases as sixth order of age, which may mean six consequential steps to cancer. But, ...
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2answers
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Studying changes in DNA for causes of cancer

First of all let me say that I'm not into Biology myself... but I have a question for those of you who are. From what I've read, cancer is caused by 'faulty' DNA that behaves abnormally. Mutations ...
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1answer
101 views

Which cells will pass cancer to offspring?

Each of these types below contains a DNA mutation. Which type(s) will affect the children of the individual whose cell it is. Red blood cell T cell Skin (epithelial) cell Neuron from the brain Sperm ...
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1answer
125 views

Is excessive hydration a risk factor for cancer in humans?

I was reading a book on radiation biology, and the book describes the process of "indirect action", where radiation can first ionize a water molecule forming a free radical, which then may interact ...
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2answers
48 views

Functioning of BRCA2

I know that BRCA2 interacts with RAD51 to repair DNA damage. But how exactly does it function ? What are the other proteins that interact with it ?
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2answers
57 views

Connection between genes and pathways

I am reading about a paper about inferencing pathway information in cancer cells. Authors refer to ERBB2 as a gene and a pathway. I don't have solid biology background. What exactly means when we ...
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1answer
53 views

What does “rapamycin-sensitive oncogenic transformation” mean?

Can someone explain exactly what "rapamycin-sensitive oncogenic transformation" is? I get that it's a drug that suppresses the immune system but what does it have to do with oncogenic transformation? ...
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1answer
916 views

Why is Sanger sequencing inferior for detecting SNPs in cancer cells?

I am familiar with Sanger sequencing, but at the level of an undergraduate. A lecturer of mine tried to describe Sanger sequencing as losing the sequence information in noise when used to detect ...
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1answer
62 views

Does increased cell turnover cause cancerous mutations?

If a certain set of cells or tissue are undergoing a lot of reproduction and repair cycles for some reason, does this inevitably lead to cancerous growths? If the mutation rate exceeds the normal ...
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1answer
37 views

Do metastatic cells still have their parent's identity?

If a liver cancer, for example, gives metastases. Will metastatic cells still have liver identity? I mean, if we mark liver cells, will we see the cancer cells too? Thanks a lot!
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1answer
35 views

Classify chemotherapy drugs?

I'm studying a TCGA dataset trying to find correlations between gene expression and clinical data which might shed light on some pathways. One column of the clinical data provides a list of ...
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1answer
54 views

About stem cells and Cancer

Do stem cells have an apoptosis mechanism and , if they do could this be used to repair the cell self-destruction pathways in a cancer cell?
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1answer
71 views

Why it is so difficult to treat leukemia?

I want to ask what is the reason that T315I type CML leukemia is currently untreatable. I have read quite a few papers in this subject. Why the current genetic oriented engineering drugs failed to ...
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1answer
137 views

EGFR, sialylation, and cancer progression

EGFR (epidermal growth factor receptor) has been intensively studied in cancer and treatments have been developed to inhibit EGFR signaling. Sialylation of EGFR is known to block dimerization and ...
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1answer
32 views

What range of dose should be used?

This is a dose-response experiment testing a new cancer drug. the darker line represents cancer cells. what range of dose should be used? I think it's 2-4 because this affects cancer cells only. is ...
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1answer
35 views

Regarding the apoptosis mechanisms in cells and cancer

If all the cells in a cancerous tumour had their apoptosis mechanisms 'turned back on' or reactivated or repaired by some 'yet to be discovered' process would this cause the tumour to 'self destruct' ...
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1answer
105 views

Are cell lines potentially dangerous?

More specifically, if a human subject was exposed to, say, a human cancerous cell line (via intravenous injection or through an open wound, for example), is it possible that they would develop any ...
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1answer
32 views

Evolutionary rationale behind migration proteins

Tumor cells are able to migrate due to specific migration proteins. What is their evolutionary origin? Or are they simply deregulated?
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0answers
24 views

Expression/Mechanism of ROR1 in healthy tissue

ROR1 is currently under investigation as a therapeutic target for cancer (1). A number of studies show different cancers may have their metastatic potential reduced, or become apoptotic through ...
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0answers
26 views

Subtypes of Acute myeloid leukemia

I am a computer scientist with no biological background and working on analyzing lab results of patients with Acute myeloid leukemia. They have been tagged with following subtypes of AML: AML with ...
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0answers
76 views

A number of questions regarding chemotaxis assay using PBMCs

In our lab we would like to study the chemotaxis of PBMCs towards conditioned medium obtained following treatment of cancer cells with different compounds. My questions are regarding the method of ...
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2answers
82 views

Cancer cure statistics questions

I have a question about cancer cure statistics. Many of the cancer literature or databases I have come across speak about 5 year or 10 year survival rates. In this case survival means that the patient ...
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2answers
76 views

Epithelial cells and Rhinovirus

If you injected a tumor with epithelial cells infected with the Rhinovirus, would this still evoke an immune response as it would with the respiratory system? Secondly, what is the specific reason the ...
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1answer
34 views

The damage of cancer cells

I read about the molecular biology of cancer, and I have a mess on my head and a lot of questions.. . My primary question is- The damage of the cancer cells is in the dna sequence or in the gene ...
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2answers
107 views

Smoking, cancer, correlation between quitting smoking and increased immediate risk

There is "proof" out there today that suggests smoking is directly linked to cancer. I cannot argue against that, for the evidence in favor appears strong, and the evidence against is lacking. I'll ...
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1answer
44 views

About the apoptosis mechanisms in a cell

The apoptosis mechanisms in a cell are like a type of 'self-destruction mechanism': is this correct? As with any type of complex system with various necessary functions, if it has a set of ...
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1answer
61 views

Do cell walls prevent cancer?

To my knowledge plants do not have an uncontrolled growth disease similar to cancer. Is the function by which they avoid uncontrolled growth related to their cell wall and preventing damage to ...
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2answers
489 views

TCGA gene expression data are missing matched normal

I'm trying to use the TCGA data portal to get gene expression data for cancer tissues, but I'm not sure what "Tumor matched normal" means. It is unclear to me if the values are already compared to a ...
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2answers
66 views

The role of antibodies interacting with cancer

I'm learning about antibodies. As I understand it, antibodies detect stranger cells/bacterial/viruses by the molecules present in their membranes. In cancer cells, the cancer cell have produce some ...
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1answer
392 views

How can the Ames test detect a human carcinogen?

Using the Ames test, we add a mutagen to auxotrophic salmonella with mutations in the histidine pathway and rat liver extract to simulate metabolism. How would we know if the carcinogen is a human ...
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2answers
55 views

What are the differences between a benign tumor and swelling?

What are the differences between a benign tumor and an injury related swelling? And can swellings due to injury turn into a benign tumor?
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2answers
66 views

In what ways can mechanisms of apoptosis be damaged?

How many ways can an Apoptosis mechanism be made disfunctional or irreparably damaged? If a cell has damaged Apoptosis mechanisms and it divides will its daughter cells have such damage?
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2answers
24 views

Concerning Apoptosis

What if cellular growth and repair is 'forced' to occur repeatedly in a region where it wouldn't normally happen , if the biological area was 'healthier'. Could this more aggressive cellular growth ...
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1answer
108 views

Carcinogens, how do they work?

The easiest carcinogenic thing for me to grasp is radiation, as it directly messes with DNA. Then it seems there are other compounds that simply mimic hormones, but these shouldn't necessarily cause ...
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1answer
54 views

What does “tumour budding” mean?

tumour budding, lymphocytic infiltration and resection margins are established factors that influence the outcome of colorectal cancer (1) In this context what does "tumour budding" mean? Reference ...
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1answer
19 views

Why does a tumour's genome change depending on the environment?

According to the book "Primer of The Molecular Biology of Cancer" by Vincent, Theodore and Ateven, the tumour cell is changed depending on its environment. performed genome-wide analysis on three ...
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1answer
415 views

What are garlic's effects on DHT?

Most antiandrogens inhibit DHT. DHT is connected to testosterone. [1] shows a beneficial effect on prostate cancer which can be caused by DHT. However, according to [2] garlic also increases ...
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1answer
38 views

Is it firmly established, that mutations are sufficient for cancer?

It is evident for scientists, that all cancer cells have some mutated genes. Say mutations in general. But this evidence means necessary condition. But what about sufficient conditions? Is it ...
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1answer
27 views

Regarding cancer cells and radio-frequency ablation

Are cancer cells destabilized if near a strong electromagnetic field over a long period of time? I read this technique of using radio-frequency ablation and heat shock to kill cancer cells. I don't ...
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1answer
63 views

Could the Warburg effect be used to starve cancer cells in situ?

What is wrong with the following chain of reasoning? Nearly all cancer cells rely on high rates of glucose uptake (upto 200 times more than normal cells). This is known as the the Warburg effect. ...
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1answer
72 views

Is the Andraka pancreatic cancer test real?

In the wikipedia article about Andraka's pancreatic cancer test there are some controversial statements. On one hand there are many glorious words about the method, also some awards, also some ...
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1answer
38 views

At what cancer stage do tumors release circulating tumor cells into the blood?

And would a very accurate sensitive system for detecting circulating tumor cells (which detects 1 cell per 50 billion) be useful as a screening tool ?
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1answer
152 views

Why are haploid cancer cells not killed by immune system?

I have seen haploid cancer cells (I think it was leukemia cells) in a lab. Sperms and eggs are haploid but are not destroyed by the body because they are protected by other cells surrounding them. ...
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1answer
78 views

What is a phospho-protein binding domain?

Is this just a domain that binds proteins that have been phosphorylated? And it mediates signalling between an activated/phosphorylated protein? How is this significant with BRCA1?
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1answer
17 views

Cancer history on environment-cancer relationship

I am interested to know how environment-cancer relationship knowledge has developed. I know that all began when Muller first proved that mutation could be induced via ionizing radiation, X rays in the ...
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1answer
84 views

Are there any examples where 'magic bullet' drugs have worked in cancer treatment?

Magic bullets are drugs that can be administered on a micro local scale. In this context administration/binding would occur in or near the tumour by exploiting the different surface antigens that ...
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1answer
27 views

Do Fatty Acid Synthase Inhibitors Selectively induce Apoptosis in Cancer cells without inducing the same in healthy human cells?

Do Fatty Acid Synthase (FAS) Inhibitors (e.g. cerulenin) selectively induce apoptosis in cancer cells without inducing the same in healthy human cells?
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0answers
25 views

Why is it important to study chromatin to understand cancer?

Many labs and many projects in biology institutes and university departments have been starting to study chromatin. Chromatin states, chromatin interactions, chromatin loopings, chromatin behaviours, ...
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0answers
30 views

Energy metabolism in Cancer cells

The TCA cycle intermediate Isocitrate dehydrogenase commonly undergoes point mutations in cancers. This allows IDH to reduce a-Ketogluterate to 2Hydoxygluterate, causing a reduction in pVHLs ability ...