A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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6
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1answer
81 views

What are the biological mechanisms behind the increase in cancer risk and alcohol consumption?

Alcohol consumption is known to be a risk factor for developing cancer. Compared to obvious causes like tobacco where one is exposed to known carcinogens, I don't see an obvious mechanism by which ...
2
votes
1answer
32 views

What range of dose should be used?

This is a dose-response experiment testing a new cancer drug. the darker line represents cancer cells. what range of dose should be used? I think it's 2-4 because this affects cancer cells only. is ...
4
votes
1answer
176 views

Why do we think chronic inflammation can cause cancer?

Why do we think chronic inflammation can cause cancer? I know the pathway is not fully understood, but what makes scientists believe that inflammation causes cancer?
1
vote
1answer
372 views

How can the Ames test detect a human carcinogen?

Using the Ames test, we add a mutagen to auxotrophic salmonella with mutations in the histidine pathway and rat liver extract to simulate metabolism. How would we know if the carcinogen is a human ...
9
votes
1answer
262 views

Can cancer grow forever if supplied with unlimited resources?

If somehow a human could give a tumor unlimited resources, would the cancer grow forever? It seems like it would until it gets so large that it physically affects vital organs. Is what would likely ...
2
votes
1answer
99 views

Which cells will pass cancer to offspring?

Each of these types below contains a DNA mutation. Which type(s) will affect the children of the individual whose cell it is. Red blood cell T cell Skin (epithelial) cell Neuron from the brain Sperm ...
12
votes
2answers
203 views

Why do most breast cancers occur in women?

According to Korde et al. (2010): Male breast cancer accounts for less than 1% of all cancers in men and less than 1% of breast cancers. This raises the question: Why do most breast cancers ...
-2
votes
1answer
85 views

What causes mutations in regulatory genes? [closed]

In detail, what causes mutations in regulatory genes?
2
votes
1answer
125 views

In cancer, why do cells duplicate themselves?

In regards to cancer why do cells replicate themselves? If it's a mutation, what kind of mutation would this be classified as?
5
votes
5answers
315 views

What is the lowest common denominator of cancer?

What is the lowest level attribute that all cancers share? Also, what is the highest level attributes that all cancers share?
4
votes
1answer
54 views

Where can I find histograms and tables of prevalence of mutations in cancer?

At some point in the past I found a cancer portal site which had aggregated data for the relationships between various mutations and their prevalence in cancer types and tumor data. The data was ...
3
votes
2answers
204 views

Do both TSG and Proto-oncogenes have to suffer mutations to cause cancer?

I'm having a conceptual nightmare trying to understand when a group of cells may become cancerous and the more resources I consult the more confused I seem to get. In order for a cell to become ...
6
votes
1answer
312 views

How similar are Circulating Tumor Cells and Cancer Stem Cells?

Circulating Tumor Cells (CTCs) are linked with metastasis and their presence can be used to indicate the onset of metastatic cancer. Likewise, the Cancer Stem Cell (CSC) hypothesis suggests that ...
8
votes
1answer
95 views

Why doesn't yearly screening for lung cancer decrease mortality rates?

In a large trial, screening yearly for lung cancer hasn't reduced mortality rates. Why is this? Isn't cancer best treatable when caught early? Is this because lung cancer is hard to treat anyway, ...
5
votes
3answers
147 views

Robotic surgery for treating cancer?

We can localise cancer cells in the body. We can manufacture materials thin and hard enough to penetrate the body without harming it. So what stops us from creating an automated surgery where the ...
10
votes
1answer
575 views

Do larger multicellular organisms have an increased risk of mutation and thus cancer?

So I was thinking that if each cell has P(X) of becoming cancerous, then the chance of cancer is 1-((1-P(X))^n) where n is the number of cells in the organism. Since larger organisms have more cells ...
13
votes
1answer
369 views

Looking for a cancer drug target database to guide sequencing of patient tumor DNA

I have a question I would like to pose to the community. I have recently received access to a bench-top ion torrent DNA sequencer. Our idea is to use this machine to sequence the DNA from patient’s ...
9
votes
1answer
103 views

What is the base cancer rate for an arbitrary carcinogen?

Are all carcinogens equally potent? Is the relationship between dose and probability of cancer roughly equal, or are there some carcinogens that provoke cancer significantly more than their cousins?