A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

learn more… | top users | synonyms

3
votes
1answer
50 views

Can we knock out Caspase-9 *and* avoid breast cancer phenotype in our mouse model?

I am trying to design a wet lab experiment with no wet lab experience to name. Right now, in my dream land, it would be excellent if it were possible to create a Caspase-9 knockout mouse (damage to ...
0
votes
1answer
18 views

How is cancer associated with host pathogen interaction?

Does cancer by any chance fall under host pathogen interaction domain? What I mean to ask is that, is there pathogen interaction involved in cancer? I went through this article: ...
0
votes
1answer
28 views

How does cancer of the larynx (laryngeal cancer) affect the respiratory system?

The larynx is part of the respiratory system and is responsible for producing sound (our voices). My question is how cancer in the larynx (voice box) affect the respiratory system overall? I ...
1
vote
0answers
40 views

Why is chemotherapy so expensive? [closed]

I have two questions related to the price of chemotherapy: I was told it was expensive, but was not able to put numbers on it. Where could I find information regarding the actual price of a given ...
1
vote
2answers
23 views

Difference between taking tissue of cancer from secondary place or primary place

Are there any differences when a surgeon takes tissue from secondary place (for example from metastasis) rather then from primary place (from an organ where cancer is) for morphological research?
3
votes
1answer
87 views

About sharks and how they find fish

Other than olfactory senses do sharks use some kind of sense that uses electromagnetic waves? Is this similar to an electric eel? I saw a book with the cover statement 'Sharks never get cancer'. IS ...
2
votes
1answer
46 views

Why is it important to study chromatin to understand cancer?

Many labs and many projects in biology institutes and university departments have been starting to study chromatin. Chromatin states, chromatin interactions, chromatin loopings, chromatin behaviours, ...
1
vote
0answers
52 views

Where can I find mutation datasets for cancer (other than TCGA)?

My lab has been using TCGA data (somatic mutations and clinical data) to develop panels of genes and of mutations we expect to see in certain cancer populations. We'd like to validate our panels by ...
3
votes
1answer
43 views

Classify chemotherapy drugs?

I'm studying a TCGA dataset trying to find correlations between gene expression and clinical data which might shed light on some pathways. One column of the clinical data provides a list of ...
2
votes
0answers
100 views

Best way to automatically link Gene Entrez ID with Gene Symbol in TCGA

I am trying to figure out how to link Gene Entrez ID with Gene Symbol, for TCGA dataset. So far, I have found this ftp directory with Gene info updated daily. But, for Entrez ID 728661, I have found ...
2
votes
2answers
620 views

TCGA gene expression data are missing matched normal

I'm trying to use the TCGA data portal to get gene expression data for cancer tissues, but I'm not sure what "Tumor matched normal" means. It is unclear to me if the values are already compared to a ...
3
votes
0answers
38 views

Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
3
votes
0answers
15 views

What is the most reliable tumour suppressing gene for NSCLC?

I was looking at some tumour suppressing genes that can be helpful in diagnosing lung cancer (particularly NSCLC - Non-small-cell lung carcinoma) at an early stage. I came across a few such as p53, ...
7
votes
2answers
205 views

Could cancer be in itself a evolutionary process?

Could cancer be in itself a evolutionary process? Maybe in some way could it be a process of variation? Or would this idea be completely without support, if so, why? I don't mean that each case ...
5
votes
0answers
33 views

How can the phenotypic effects of a tumor suppressor mutation be silenced?

I've been reading a little about the "two-hit" hypothesis for tumor suppressor genes here, which mentions that some genes exhibiting haploinsufficiency are exceptions to the hypothesis. I've read ...
0
votes
1answer
31 views

How to tell if a given gene is a tumor suppressor or oncogene?

This is a problem taken from "Concepts of Genetics", Klug et al, 10e. I'm given the following table about the mutations in the BRCA1 gene: $$\begin{array}{c|c|c|c|c} ...
0
votes
2answers
75 views

Difficulties understanding a pathway [closed]

I am not a biologist and I would love to understand what is going on with this pathway. I went to the description but it's still complicated, and I couldn't follow. Can someone please help me with it? ...
3
votes
3answers
65 views

Can bioluminescence be used for cancer or tumor detection? [closed]

What diagnostic applications, if any, are there in using bioluminescence to detect cancer or tumors (in vivo)?
2
votes
1answer
52 views

Energy metabolism in Cancer cells

The TCA cycle intermediate Isocitrate dehydrogenase commonly undergoes point mutations in cancers. This allows IDH to reduce a-Ketogluterate to 2Hydoxygluterate, causing a reduction in pVHLs ability ...
4
votes
0answers
55 views

Contact Inhibition of Cell Division: Signaling Pathway

The following article refers to contact inhibition of cell division in epithelial cells, specifically MDCK cells: Collective and single cell behavior in epithelial contact inhibition. In their review ...
3
votes
1answer
55 views

Expression/Mechanism of ROR1 in healthy tissue

ROR1 is currently under investigation as a therapeutic target for cancer (1). A number of studies show different cancers may have their metastatic potential reduced, or become apoptotic through ...
7
votes
3answers
2k views

How fast do cancer cells divide, compared to normal cells?

This question suggests that we have, on average, 50-70 billion cell divisions per day. I just read that cancer cells divide more often and are therefore more prone to radiation. I am wondering, for ...
2
votes
1answer
183 views

Are cell lines potentially dangerous?

More specifically, if a human subject was exposed to, say, a human cancerous cell line (via intravenous injection or through an open wound, for example), is it possible that they would develop any ...
5
votes
1answer
130 views

Telomerase as cancer target

There are a lot of publications, starting from 2000, about using telomerase for targeting cancer cells (it is upregulated in more than 80-90% of tumor cells). Specifically using its promoter (hTERT). ...
3
votes
1answer
96 views

What type of flask should I use to culture NTERA2 embryonic cancer stem cells?

I'm just starting my MSc research and I am in the process of making a list of equipments/consumables to order. Is there a specific flask in which I can culture NTERA2 (NTERA2/D1) cell line?
10
votes
2answers
640 views

Are all mutagens carcinogens?

Not all carcinogens are mutagens. Alcohol and estrogen, for example, does not damage DNA. It's one of the assumptions of the Ames test that mutagenicity implies carcinogenicity, but is this always ...
1
vote
1answer
23 views

What are the roles of cadherins in epithelial mesenchymal transitions? [closed]

I know that cadherins control the expression of cancer cells involved in the epithelial-mesenchymal transitions, but I was wondering exactly how the process worked.
1
vote
1answer
38 views

Enzyme\Protein amounts in cancer

I am searching for source, that providing information about enzymes\proteins, in different types of cancers, that their amount in cell is significantly higher - comparing to normal, healthy cell. ...
1
vote
1answer
26 views

Mitochondria variability per tissue in humans?

I would like to know the distribution of mitochondrial content per tissue type in humans. I understand the simple metric that energetically active or energy requiring tissues will have more ...
10
votes
1answer
94 views

Why do people with Down syndrome get fewer cancers?

I'm coming across some conflicting information regarding the correlation between cancer incidents and trisomy 21. I read a report from nature that discusses how Downs are only a tenth as likely to ...
1
vote
2answers
54 views

Why mutations in genes involved in general processes like DNA repair increase the risk of developing specific types of cancer?

For example, mutation in MHS2, which encodes a protein involved in the repair of mismatches that occur during DNA replication, dramatically increases the risk of developing colon cancer. (There are ...
0
votes
1answer
26 views

What sort of assay could be used to identify mutants with mutator phenotype? [closed]

By mutator phenotype, I mean being more prone to mutations, for example due to mutations in genes involved in DNA repair. I was thinking about exposing the cells to agents that damage DNA (uv light, ...
4
votes
2answers
180 views

In cancer, why do cells duplicate themselves?

In regards to cancer why do cells replicate themselves? If it's a mutation, what kind of mutation would this be classified as?
0
votes
0answers
20 views

How can I classify Breast Cancer if I have incomplete receptor information?

I have a clinical data table for a cohort of Breast Cancer patients and I want to classify them as being either triple negative or triple positive. You can find the file here. For some of the ...
8
votes
2answers
59 views

All UniprotIDs of a cancer pathway

I need to download all uniprotIDs of a cancer pathway, say the AKT Signaling. It may be super easy, but I don't know which resource to look at since it is a new field. How/where do I find these?
2
votes
1answer
90 views

Does increased cell turnover cause cancerous mutations?

If a certain set of cells or tissue are undergoing a lot of reproduction and repair cycles for some reason, does this inevitably lead to cancerous growths? If the mutation rate exceeds the normal ...
3
votes
1answer
72 views

What does it mean when a patient suffering from malignant tumor (cancer) has been declared cured?

Comment by Anongoodnurse, has made me curious as to what a doctor means when (s)he says "The cancer is cured" to a patient. My idea up till this point (based on what I read and what I learned in my ...
1
vote
2answers
97 views

What are the differences between a benign tumor and swelling?

What are the differences between a benign tumor and an injury related swelling? And can swellings due to injury turn into a benign tumor?
8
votes
1answer
612 views

Have there been studies done to test Immortality of Cancer Cells on culture?

The article here says cancer cells may be immortal. I am wondering if there has been any research done to find if cancer cells are really immortal. How old is the still maintained living oldest ...
6
votes
2answers
444 views

What are the differences between cancer and tumour?

What are the differences between cancer and tumour? I mean is it in the DNA or shape or something else... And how can a benign tumour turn into a malignant tumour? The body has a lot of tumours all ...
1
vote
1answer
21 views

Why does a tumour's genome change depending on the environment?

According to the book "Primer of The Molecular Biology of Cancer" by Vincent, Theodore and Ateven, the tumour cell is changed depending on its environment. performed genome-wide analysis on three ...
1
vote
1answer
38 views

The damage of cancer cells

I read about the molecular biology of cancer, and I have a mess on my head and a lot of questions.. . My primary question is- The damage of the cancer cells is in the dna sequence or in the gene ...
0
votes
1answer
11 views

About artificially induced processes that would normally cause a cell to self-destruct

Are there certain biochemical processes that would normally cause a cell to self-destruct but if the cell being tested has apoptosis mechanisms that have malfunctioned or been 'turned off' the cell ...
3
votes
1answer
60 views

How is the growth of benign tumors suppressed?

A benign tumor has an outer layer of cancerous cells beyond which are regular cells (I Think). The Tumor must have some kind of boundary layer like a wall where somehow the cancerous cells can't ...
0
votes
0answers
28 views

Superpatients for Cancer resistance

I was reading an article on MIT Technology review about superpatients for low cholesterol that got me thinking whether such patients exist for cancer. The article is ...
1
vote
1answer
47 views

About the apoptosis mechanisms in a cell

The apoptosis mechanisms in a cell are like a type of 'self-destruction mechanism': is this correct? As with any type of complex system with various necessary functions, if it has a set of ...
5
votes
1answer
33 views

About radiation therapy

With radiation therapy, could some of the radiation used cause new mutations in non-cancerous cells that are near the tumour that is being irradiated? If so could these new mutations lead to new ...
11
votes
2answers
214 views

Why should a tumor look like a crab?

Origin of the word cancer The disease was first called cancer by Greek physician Hippocrates (460-370 BC). He is considered the “Father of Medicine.” Hippocrates used the terms carcinos and ...
6
votes
4answers
133 views

Can a tumor produce something not currently found in our own bodies?

While speaking with my co-workers, the topic of tumors growing things came up. The examples were (and backed by images) of tumors growing a tooth, hair, and sometimes even more complex objects such ...
3
votes
1answer
28 views

Regarding tumors and their developement

If certain cells or tissue in a specific part of the body are for some reason overworked; like the cases of severe acid reflux damaging the throat repeatedly and the cells in the throat having to do ...