The study of cells: their physiological properties, structure, environmental interaction, division, life cycle, and death, as well as the organelles they contain. Also known as cytology.

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542 views

Is there a relationship between efficiency of cellular metabolism and warm-blooded-ness?

My BIO 101 book states that when human cells convert glucose to ATP, the process is only approx 35% efficient, and much of the potential energy is lost as heat. However, that heat is useful to us in ...
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168 views

What's a good reference for choosing histological staining chemicals?

It's often difficult to find the appropriate or best stain to use when I want to examine a new type of tissue. I think that's partly because many histological techniques were developed a long time ...
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7k views

How do archaea relate to eukaryotes and bacteria?

I've read that they all share some genes, internal structure, and behaviour with each other, but with different degrees of overlap depending of what the function is. E.g., archaea have some eukaryotic ...
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129 views

Regarding TIMP and MMP enzymes

Are there substances that can promote TIMP enzyme production, or MMP enzyme production or supression in tendons? Are there medical tests that measure quantities of MMP and TIMP enzymes in tendons?
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73 views

Macrophage pathogen fixation

Overly simplified, macrophages recognise pathogenic patterns and endocytose anything that matches them. That also works on bacteria, which are quite often very mobile. What if a bacterium was just ...
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33 views

Where can I find a transcriptome of a normal uveal melanocyte?

I am looking for a database where I could find a transcriptome (say obtained with a microarray analysis) of one (or ideally many) normal uveal melanocytes ?
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131 views

Which cells are responsible for the extracellular matrix remodeling?

I am studying a case of tendinopathies induced by an alteration of how the extracellular matrix is being remodeled. From my understanding there has to be a careful balance of MMP (metallproteinases) ...
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322 views

Are the cytosol and extracellular fluids electrically neutral?

I've found several sources that state that overall, the cytosol of a cell is electrically neutral. The extracellular fluid is also purportedly electrically neutral. How can that be when we have ...
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89 views

Synthetic biology using existing cells

I was watching the video at this link: http://www.bbc.co.uk/news/science-environment-17436365 The speaker says that a cell is taken and its original DNA content is stripped out and replaced with ...
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24 views

What metabolically happens when an egg fuses with the nucleus of a somatic cell

In stem cell biology, it is recognized that embryonic stem cells are transcriptionally inactive for the first 3 days of development. However, during somatic cell nuclear transfer, the nucleus is ...
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1k views

Is the eukaryotic nucleus composed of a single or double membrane?

I know that it is usually considered a double membrane like those surrounding mitochondria and chloroplasts, but I read a review that stated "according to topological details it is actually a single ...
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283 views

How similar are Circulating Tumor Cells and Cancer Stem Cells?

Circulating Tumor Cells (CTCs) are linked with metastasis and their presence can be used to indicate the onset of metastatic cancer. Likewise, the Cancer Stem Cell (CSC) hypothesis suggests that ...
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346 views

How does a cell know its size?

Cells come in all sorts of sizes. How do they regulate their cell size to the point where similar cell types have a fairly mono-disperse size distribution? Reasked from ...
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70 views

How do nuclear receptors locate each other to form a DNA loop?

Nuclear receptors can influence transcription far up- or downstream from their own binding sites by looping DNA (Rubina et al.; J Mol Bio 2004). I am not sure how exactly the receptors first attach ...
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619 views

What is the main general difference between Mitosis and Meiosis?

I found such a clause: The general principle is that mitosis creates somatic cells and meiosis creates germ cells. However, I cannot agree. Each gametogonium needs to go through mitosis before ...
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56 views

Measuring the density of surface antigens

I'm trying to get a sense of the variety of methods used for determining the number of cell surface antigens and receptors. This is notably different from determining the affinity of these surface ...
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330 views

What's the distinction between a tetrad and a synaptonemal complex in meiosis?

What's the distinction between a tetrad and a synaptonemal complex in meiosis? Are they synonyms? I ask because the concepts seem very closely related, but it seems like there may be a subtle ...
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416 views

Do larger multicellular organisms have an increased risk of mutation and thus cancer?

So I was thinking that if each cell has P(X) of becoming cancerous, then the chance of cancer is 1-((1-P(X))^n) where n is the number of cells in the organism. Since larger organisms have more cells ...
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189 views

When collecting cell lysates for a Western blot, how do I induce di-sulfide bonds?

I would like to conduct a simple dimerization experiment for some protein I'm collecting from a cultured cells. My thought is, that if I'm running a non-reducing, denaturing PAGE gel, then removing ...
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6k views

What is the difference between “dikaryotic” and “heterokaryotic” states in the sexual lifecyles of fungi?

Many fungi undergo a reproductive phase in which more than one genetically distinct nuclei (from 2 separate mating types) is present within the same cytoplasm. In the Ascomycota and Basidiomycota, ...
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476 views

What is a inhibitory tone when talking about neurons?

In this SE answer: Could an "overactive" brain increase the chances of Alzheimer's Disease? user @nico used the word inhibitory tone What does that ...
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216 views

How crowded is the bacterial cell?

I was wondering what is the protein concentration in an E. coli cell. When studying enzyme kinetics and activity in vitro, I would argue that the substrate and enzyme concentrations resemble those in ...
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77 views

Pancretic Acinar Cell - ATP, calcium concentration data

I need to find a decent source of data for concentration of ATP and calcium in the pancreatic acinar cell. So far all I can find is ATP or calcium 'levels' based on fluorescence , which are not ...
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265 views

How is the number of mitochondria in a cell regulated?

How does the cell regulate the number of mitochondria in a cell? What happens when there are too many or too few?
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655 views

How does water buffer a sudden drop in temperature?

A property of water is that it is slow to heat and cool. According to my biology book, some energy from an increase in temperature would spent breaking hydrogen bonds, so that temperature does not ...
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587 views

How long will a vegetable live for after being harvested?

I understand this might depend on the types of vegetables, but is there an average or studied specifics? Does it die immediately? Is there a way to precisely diagnose death in plants? If so, what are ...
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520 views

Are lymphocyte sizes clustered in two groups?

Tortora writes in Principles of Anatomy and Physiology: Lymphocytes may be as small as 6–9 μm in diameter or as large as 10–14 μm in diameter. Those ranges are quite close to each others. Should ...
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65 views

How are chromatids correctly segregated during mitosis?

In my book this is described as happening by kinetochores depolymerising from their attached microtubule spindle, then being dragged towards the spindle's centrosome by a dynein protein. I can ...
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496 views

Did researchers evolve multicellular yeast or did they just turn on multicellularity?

In this new paper "Experimental evolution of multicellularity" found via Ars Technica the researchers describe having developed multicellularity and apoptosis within 60 days from a unicellular yeast ...
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956 views

How does the Golgi Apparatus perform its function?

The Golgi Apparatus is an organelle with a great number of functions, I am particularly intrigued in the role it plays in packaging macromolecules and sending them to their target organelle or to ...
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199 views

Is “exhaustion” of the Hodgkin-Huxley membrane at constant stimulation a real phenomenon?

I was playing around with a simulation of the Hodgkin-Huxley model using their original parameters for the squid giant axon. By applying a constant stimulation current to the model in resting state, ...