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Temporal effects on pathways?

I was wondering whether or not there exist certain pathways that are triggered by a temporal signal. We're almost at the winter solstice now. Does animal or plant function involve signals that are ...
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histamine inter-cellular and cytoplasmic binding site

I noticed that HRH (histamine receptor) has an inter-cellular and cytoplasmic binding site of anti-histamines which are equal in binding energy. Does anyone know what is the function of the well ...