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9
votes
2answers
305 views

Why does Hunger lead to the aggressive behavior?

I have observed that frequently when people are hungry; they tend to get angry more easily on pointless issues. Does this mean that our fight or flight response is more active when a person is hungry? ...
6
votes
1answer
436 views

Cat purring: What are some possible underlying mechanisms behind purring and bone remodeling and formation?

http://www.scientificamerican.com/article.cfm?id=why-do-cats-purr The article above says that cats purr mostly when they're wounded or under duress. They hypothesis that cats purring leads to ...
6
votes
4answers
75 views

Exocytosis of mast cell secretory granules

I've been doing a bit of reading about mast cell degranulation and have become thoroughly lost while trying to understand how the secretory granules are actually secreted. I understand that there are ...
6
votes
1answer
231 views

Models of quorum sensing for multi-agent systems

Quorum sensing is a system of stimulus and responses correlated to population density that is used by bacteria to coordinate gene-expression. I am looking for a simple computational/mathematical model ...
5
votes
2answers
274 views

Signaling through G protein Coupled Receptors?

There are two different cell lines but we do not know that these cell lines have Gs or Gi proteins, associated with their G-protein coupled receptors. If we wants to know about this. Can we design a ...
4
votes
4answers
162 views

Specificity of Protein Kinases in Signaling Pathways..?

In most of the signaling pathways the activated receptor when activates Protein Kinase through the action of secondary messenger, then these protein kinases almost always phosphorylate on the specific ...
4
votes
2answers
98 views

Effect of steroid hormone on specific cells?

As steroid hormones can pass through the plasma membrane by simple diffusion because they are lipid derived hormones, it means that they are capable of passing through every cell of our body, BUT why ...
4
votes
2answers
134 views

Effect of testosterone hormone on cell signalling and behaviour?

A steroid, testosterone was injected in female body which led to development of secondary sexual characters but these characters were not developed over night (Response was very slow). What could be ...
4
votes
1answer
107 views

which signalling pathway is involved in cancer?

Columnar epithelial cells from the colonic mucosa are studied to identify abnormalities in cell signaling pathways. Abnormal epithelial cells from colonic adenocarcinoma are shown to have a mutation ...
4
votes
2answers
332 views

Question about cell signaling pathways (RTK, Jak-Stat, SMAD, etc)

I am in an embryology course right now and we've just started covering cell-cell communication in development. We were talking about the roles of the various cadherins and their discoveries but we got ...
3
votes
1answer
90 views

How do GPCRs transmit a signal across the plasma membrane?

How do G-coupled protein receptors (GPCR) transmit signals through the plasma membrane? Links containing information about this and pictures will be very helpful.
3
votes
1answer
50 views

Significance of lipids in biological membranes…?

Membranes are specifically designed by lipids to maintain internal hydrophilic environment in narrow range.There are hydrophobic amino acids among naturally occurring 20 amino acids and as well as ...
3
votes
1answer
61 views

Amino acid profile of GPCRs

You are studying cellular signalling through a newly identified GPCR. Specifically you’re working on a pair of newly identified GPCRs, GPCR-A and GPCR-B. Each binds the same small ligand, but ...
2
votes
1answer
40 views

Why do oncogenes show genetic dominance?

As we know that tumor suppressor gene causes cancer only when both the alleles are recessive in nature.But in case of oncogenes if only one allele is dominant it can cause cancer.Why in case of ...
2
votes
1answer
58 views

Structure of biological membranes?

Integral membrane proteins have functional asymmetry i.e. they have two different domains of proteins performing different functions. these proteins have Tyr and Trp amino acid residues at the ...
2
votes
1answer
66 views

Can (any) human cells learn?

I'm not talking about single celled organisms, but actual cells in your body. Is there any evidence that they can learn to, say, navigate an environment or avoid an aversive stimulus like an animal ...
2
votes
2answers
362 views

Explanation of the terms “downstream signaling” and “upstream signaling”

In molecular biology, what's the meaning of the terms "downstream signaling" and "upstream signaling"? What's the difference between them?
2
votes
1answer
36 views

Regarding signalling pathways

Do all signalling pathways have something that can inhibit them? If the signal pathway is benefitial and it is inhibited would the inhibitor be caused by a biological problem? Are all inhibitors ...
2
votes
1answer
66 views

Autophagy in eukaryotic cells

What is autophagy? How and under which circumstances is it used by the cell? I believe The reason for autophagy is some kind of recycling, am I right? But why does it occur in infections?
1
vote
1answer
60 views

Meaning of “auto” in trans autophosphorylation?

Why this process called "auto"? Is it because each tyrosine kinase receptor subunit of the RTK dimer has the ability to phosphorylate tyrosine or other amino acid residue present in other subunit of ...
1
vote
1answer
52 views

What is the functional significance of the difference in cardiolipin/cholesterol ratio in different membranes?

I have read somewhere that the plasma membrane has little cardiolipin but excess cholesterol whereas the inner mitochondrial membrane is rich in cardiolipin and has little cholesterol.I just wanted to ...
1
vote
1answer
92 views

Transverse diffusion of lipids in red blood cells

The membrane of a human erythrocyte has polarity: Phosphatidylethanolamine and phosphatidylserine are predominantly on the inner side. Phosphatidylcholine and sphingomyelin are predominantly on the ...
1
vote
1answer
27 views

Why can't intermediate filaments be used as tracks by motor proteins?

A motor protein like kinesin-1 cannot use an IF as a track because it lacks polarity. Can someone elaborate on this answer?
1
vote
1answer
62 views

What is a phospho-protein binding domain?

Is this just a domain that binds proteins that have been phosphorylated? And it mediates signalling between an activated/phosphorylated protein? How is this significant with BRCA1?
1
vote
1answer
127 views

How do axon terminals report to the soma?

It is important to bear in mind that the distance between a neuron's axon terminal and its soma can be extensive, up to about 1m in the human body. The fastest transport along the axon is 400mm/day ...
1
vote
0answers
23 views

Temporal effects on pathways?

I was wondering whether or not there exist certain pathways that are triggered by a temporal signal. We're almost at the winter solstice now. Does animal or plant function involve signals that are ...
1
vote
0answers
14 views

histamine inter-cellular and cytoplasmic binding site

I noticed that HRH (histamine receptor) has an inter-cellular and cytoplasmic binding site of anti-histamines which are equal in binding energy. Does anyone know what is the function of the well ...
0
votes
1answer
29 views

Modern research or study on patterns in nerve signals

I am trying to find any recent study on pattern recognition in nerve signals. It does not really matter the part of the body where the research is focused on. It can be anything from studying activity ...
0
votes
0answers
36 views

The roles of RhoA, Rac and Cdc42 in cadherin signalling

I'm a little confused over the roles of RhoA, Rac and Cdc42. From this text it would seem that when cadherins form a junction with one another RhoA is inhibited, whilst Cdc42 and Rac is activated. ...
-1
votes
1answer
53 views

Bilayer synthesis? [closed]

If we want to design a bilayer from Myristic acid (14 carbon fatty acid). The average bond length between C-C is 1.5 A. What will be average thickness of the membrane? Edited to include the OP ...