Tagged Questions

Chromatin is the complex of DNA, histones, and other scaffolding proteins that make up the chromosomes, which in eukaryotes is located in the nucleus of the cell.

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What are “anchor regions” in the human genome?

I've been reading this paper entitled "A high-resolution map of the three-dimensional chromatin interactome in human cells", about interactome in 3D chromatin. We next applied the above algorithm ...
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1answer
27 views

In chromatin, what are the differences among states, interactions, and structures?

I am new to the study of chromatin, and I am trying to understand what people mean when they write about chromatin states, chromatin interactions, and chromatin structures. What are the difference ...
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267 views

Properties of Satellite Chromosomes

I have some questions regarding Satellite chromsomes which could not be resolved by a google search. Does the satellite consist of telomeric sequences ? If not, What is the function of a satellite ? ...
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90 views

Chromatin shearing: what is it and what are the effects of high-sensitivity?

I am reading a paper which discusses a complex (MSL-DCC) involved in dosage compensation of the drosophila X-chromosome. Descriptions of the complex's structure and function are given in the papers ...
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71 views

Transcriptionally-mediated DNA damage

I'm researching the genetics of brain cancer, and finding a huge number of mutations in voltage-gated channels. It stands to reason that some of this DNA damage is due to the DNA being transcribed ...
3
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1answer
67 views

How can chromatin state be measured?

I have some RNA-Seq data and I'd like to align it to the physical genome and see which sections of chromatin are geometrically open and being transcribed. The data are already sequence-aligned, and ...
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405 views

Regulation of chromatin structure

Recently, I reviewed the different levels of chromatin structure. The primary level is nucleosomes, where DNA is bound to histones, and has structural similarity to "beads on a string." The secondary ...
4
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147 views

Bacterial chromatin binding data?

I'm looking for data - maybe CHP^2 data that shows chromatin binding to a prokaryotic genome under some specific conditions. Can anyone point me to a source?