Deoxyribonucleic acid (DNA) is the carrier of genetic information, including for all known living organisms. The only known exceptions are RNA viruses.

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How are 23 chromosomes in human sperm chosen?

I'm not biologist and I have just a basic knowledge. I've been thinking for a long time about the following question: How does the body choose which 23 chromosomes should be active in human sperm and ...
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27 views

How do genetic chimeras with different blood types not die?

If a person is a chimera and has two different blood types in his veins, how does he not die? Shouldn't the immune system attack one of the blood types? In 1953 a human chimera was reported in the ...
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Link between macro lncRNA and DNA looping

I was wondering if anybody knows some publication about macro lncRNA (very long unspliced RNAs) or more generally a transcribed RNA that may lead to cis-DNA looping of genomic regions overlapped by ...
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53 views

Why does high pH result in the denaturation of DNA?

In the Southern blot method, for example, a solution of NaOH is used to denature the DNA in the sample. I find this counterintuitive since I expected that $\text{Na}^+$ cations would neutralize the ...
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What are the major causes of mutations in DNA?

I know that point mutations can change the base sequence of a gene by altering a specific codon that codes for a particular amino acid. Are these mutations purely random events that occur when DNA is ...
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41 views

How does the size of insert affects the rate of Homologous Recombination in yeast?

When performing genetic knockouts in yeast using homologous recombination to replace a target gene sequence via a vector DNA, does the region between the flanking regions in the vector have to be the ...
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DNA replacement: new species

This is a hypothetical question What would happen if the DNA of a prokaryote was replaced with the one of a prokaryote of another species, would the cell structures change and adapt to the new DNA ...
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85 views

Pros/cons: linear vs. circular DNA [duplicate]

Why did Eukaryotes evolve to have linear DNA and not circular like Prokaryotes? What are the pros and/or cons?
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41 views

Core architecture of the body encoding [closed]

First of all, I am not a biology guy; I am in Computer Science. But, I have a strong interest in all the mysteries of nature, from universe to human body. So, I want to ask a question related to ...
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52 views

Can DNA & RNA be considered as nature's programming language?

The final frontier of Biological Sciences could be considered understanding the effects of variation in the DNA (and RNA). If after fertilization the DNA of the zygote could be genetically ...
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71 views

What is biological dark matter?

I recently stumbled upon the Biological Dark Matter wiki page. Its pretty light on details, but it appears to be genetic material found in humans that doesn't fall into currently classifications. ...
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32 views

DNA barcoding and real-time PCR

I recently read an article on how DNA barcoding was used to identify species present in health products. I also read an article about how Real-Time PCR was used to identify meat species in meat ...
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How do I find a protein from this DNA sequence?

I have a DNA sequence from a sequencer. How can I determine what protein is it? I tried some translator but it didn't help. What protein is this and how can I determine it? The sequence: ...
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Why is it that heterozygous loci appear as two separate bands during gel electrophoresis while homozygous loci appear as one band?

Is it because heterozygotes have a greater base pair length? (And if they do, why is that?) Or is it because recessive alleles are moving slower than the dominant alleles in the gel?
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What is it about the housekeeping genes that makes them almost immune to gene regulation?

When it comes to eukaryotes, including ourselves, we have all different kinds of specialized cells and tissues that are so different, yet originally all came from the same single cell. And apparently ...
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351 views

How are we able to find the specific sites at which DNA binding proteins bind?

We know that some DNA binding proteins are site specific, that is they recognise and bind to a specific nucleotide sequence. My question is how can we precisely tell at which sites they bind? Is it ...
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SNPs and locations

I am new to reading raw DNA. When comparing two people's raw data, why does one person have a different SNP than the other, at the same location, on specific chromosome? But on a different chromosome ...
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Plasmid in the nucleus and gene expression

If we insert a plasmid into a human nucleus that contains exact copy of gene and all relevant promoters to produce some human protein, will the cell create functional protein from that plasmid only ...
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Can genetic engineering be performed without a laboratory setting? [closed]

I'm becoming more interested in genetic engineering as I learn more about it, and it's becoming more and more apparent that there's very few resources on genetic engineering at home. A similar ...
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Transfect Mammalian Cells with Single Stranded DNA?

Agrobacteria can deliver parts of their DNA to plant cells as T-DNA, transfer DNA. This DNA is delivered as a single strand and can be integrated into the plant genome or can be converted to a double ...
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45 views

Repair wrong DNA pair after ending replication?

If there are wrong DNA pair, for example A=G, is there mechanism that could repair such things - after the replication was finished? Or it happens only during replication?
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34 views

The damage of cancer cells

I read about the molecular biology of cancer, and I have a mess on my head and a lot of questions.. . My primary question is- The damage of the cancer cells is in the dna sequence or in the gene ...
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1answer
48 views

Could we engineer humans to behave like insects? [closed]

First off, though complex, I'm assuming insects are at an earlier evolutionary stage than humans. That being said, could humans be genetically engineered to behave like insects? I'm not talking about ...
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why is DNA antiparallel? Can it be parallel?

My biology textbook mentions that DNA is antiparallel and it got me wondering... Can DNA be parallel? What would happen if it was parallel? could DNA still replicate right?
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Known ways to modify the genetic structure of the 13 loci used in CODIS

After reading the answer to Does our DNA change during our lives?, I was wondering if and how it would be possible to change the structure of the 13 loci that are used in the CODIS database, in such a ...
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How semi-synthetic cell with artificial DNA works

I know that by now this is old new but I heard that a cell that used a synthetic pair of nucleotides, called X and Y, have been made. My question was, how did the cell understand the X and Y ...
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Does a man contain all the genes needed to make a woman?

This question is brought on by a Sci Fi novel I am thinking about writing. The plot device involves a colonist in charge of building a population on a new planet who loses his supply of embryos and so ...
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Why do some cells like myofibrils have multiple nuclei?

I see that myofibrils (muscle cells) contain not one, but multiple nuclei. Why is this so? Do all the nuclei participate in cell division?
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Can cfDNA testing distinguish results in the case of twins?

A fetus can now be screened for some of the more common genetic diseases and its sex determined from just a whole blood sample from the pregnant mother. Fetal DNA is abundant enough in the systemic ...
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How fallible are DNA paternity tests?

Is it possible to get either a false positive or a false negative from a DNA paternity test and what would be the likely mechanisms behind this? For example, is it possible that a father's DNA could ...
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Superpatients for Cancer resistance

I was reading an article on MIT Technology review about superpatients for low cholesterol that got me thinking whether such patients exist for cancer. The article is ...
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How is DNA Read

Little odd question here. I was told that DNA was read in groups of three. Assuming this, my question is: Which way would better describe how the DNA is read. (123)456789 to 123(456)789 to ...
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47 views

Will gene mutations give rise to a protein that is shorter than the full length protein?

What is the relationship between deletion or insertion of nucleotide in the gene sequence and the protein's length that is coded out from the mutated gene?
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35 views

G>T transversion VS. T>G transversion?

So I'm reading about how mutations in DNA can be caused by oxidative damage. An example of a product of oxidative damage is given: 8-oxo-7-hydrodeoxyguanosine My textbook says that this product ...
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Why do the major and minor groove exist in DNA?

So I know that the major/minor groove arise from the offset pairing of the two strands in the helix. All my textbook tells me is that "pitch causes the off-set pairing of DNA and this gives rise to ...
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Why deoxyribose for DNA and ribose for RNA?

Why is DNA made out of deoxyribose and RNA made of ribose? Why can't they both use ribose or deoxyribose? I think that the deoxyribose gives an advantage in storing genes, the job of DNA and ribose is ...
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Why does DNA have its name?

Why is DNA called deoxyribonucleic acid and not something else? I get the nucleic acid part (because that's what DNA is made of) but what about the deoxyribo- part, especially the ribo- part. Maybe ...
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PCR cycle problem [closed]

IF I began a PCR cycle with 5 copies of a particular DNA section, and copied the section by PCR, for 6 cycles, how many copies of the DNA (include the originals) would I have by the end of these ...
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What makes DNA sticky-ends sticky?

When restriction enzymes jaggedly cut double stranded DNA it results in so called sticky ends. What is the substance that makes the DNA sticky?
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Low copy numbers of plasmids

I have a plasmid with the P15A origin which apparently has a low copy number (see here). This would explain why my purification yeilds for subsequent digestion are low (gel shows the plasmid after ...
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Are there any similarities in the DNA of a humans and animals? [closed]

As the title says, i've been wondering if there are any similarities between the DNA of humans and the DNA of animals? Like, maybe monkeys are more similiar in their DNA to humans, than dogs are (to ...
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660 views

Why does A pair with T and G with C?

DNA is made up of pairs on AT and GC base pairs. I know that A only pairs with T and G only with C. Does this apply just to humans, or are there animals where T will pair with G? Also, surely there ...
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Calculating number of amino acids in mRNA

Assuming there were 20 different amino acids and less than 40 types of different tRNAs found in this alien organism. How many amino acids would be found in the translational product of a ...
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Is the nuclear envelope present in G1 of interphase?

Is the nuclear envelope present in G1 of interphase of eukaryotic cell? If so how does a method like Calcium mediated transfection get DNA past the nuclear envelope?
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660 views

Importance of Double Helix DNA Structure

Gene expression involves transcribing only one strand of DNA molecule. So i was wondering what are some biological advantages of the double stranded DNA?
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Why is the threshold between human embryo and human fetus defined as 8 weeks after fertilization?

Why is the threshold between human embryo and human fetus defined as 8 weeks after fertilization? What's happening on the 8th week? Note: definition of embryo based on Wikipedia's current ...
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Has DNA communication/interaction at a distance been empirically demonstrated?

I recently had a discussion with a statistician in my school about memory. Among other things, he told me that it has been experimentally demonstrated that when one extracts DNA from any organism and ...
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Nucleosome wrapping direction

Does anyone know which direction the nucleosomes are wrapped? I wonder: Relative to the B-DNA double helix twist direction (right-hand) Relative to the neighbor nucleosomes. Do they alternate to ...
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Redundancy of the genetic code

One particular codon codes only for one amino acid, but an amino acid can be coded for by several different codons. Now according to the genetic code, the codon UUU ...
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74 views

What kind of technology is required for plant seed DNA printing? [closed]

I'm a programmer so I have little knowledge in the field of biology. However I have an interest in plants, GMOs and DNA (in terms of programming). So, I want to know what kind of technology is ...