A structural aberrancy in DNA, as opposed to a sequence change (mutation). Often caused by reactive species.

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Does vitamin C decrease after reacting with oxygen free radicals?

From the research that I have done, I know that antioxidants such as vitamin c donate electrons to oxygen free radicals and effectively neutralize them. They themselves do not become free radicals as ...
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transitional mutation, repair mechanism

I have read an answer to a question about dna repair during and after replication. But how is dna repaired if a deamination of of 5-methylcytosine happens? How does a repair mechanism identify which ...
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Which is the best way to fix and preserve comet assay slides before staining with Ethidium Bromide?

I want to use the method of Single Cell Gel Electrophoresis (comet assay). I have many samples, but I don't have the appropriate microscope. So I have to preserve my slides until the time comes for ...
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Base Excision Repair and Nucleotide Excision Repair

What's the difference between BER and NER? I understand that BER removes the improper base, while NER removes the nucleotide (including the base). However, in BER, don't repair enzymes then remove ...
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Components of DNA repair and DDR

Many of the molecules involved in DNA repair, specifically Homologous Recombination, do not have clear differentiation from DNA Damage Response Pathway. What is the best journal article that makes ...