A structural aberrancy in DNA, as opposed to a sequence change (mutation). Often caused by reactive species.

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Can cancer cells in the same person, organ, and origin have different DNA?

Is it possible for cells from the same tumor to have different genetic material, and if so, to what degree is it possible (how fast do they mutate) ?
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839 views

Difference between mutation and DNA damage

What is the strict difference between mutation and DNA damage? As far as I understand it, a mutation is an alteration in the genetic sequence, having "tricked" the repairing machinery and thus ...
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Is a single x-ray photon capable of doing enough damage to the dna of a cell to kill that cell?

Ionizing radiation is damaging to DNA, but is there such a thing as a safe dose below which no DNA damage could occur? I'm not asking about a minimum safe dose overall, just whether or not there's an ...
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2answers
88 views

Stay young by reinserting own DNA from years ago?

As far as I know, the DNA sequence becomes shorter every time a cell divides. A shorter sequence results in information loss and aging characteristics. As a countermeasure, shouldn't one stay young ...
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3answers
72 views

If everybody DNA is different then how blood can match even with matching blood group?

We know that everybody's DNA pattern is different in the world. Then how can ┬┤we transfer blood from one person to another person and this person can survive ?
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81 views

Question about the DNA glycosylase enzyme assay/formamide gel loading buffer

Often for the DNA glycosylase enzyme assay we can see that the DNA glycosylase is incubated with oligonucleotide in 37C and then reaction is stopped by addition of formamide gel loading buffer (80% ...
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75 views

Do mitochondrial DNA have repair enzymes?

Mitochondria are considered endosymbionts originated from a prokaryote. So, do they have a DNA repair mechanism ?
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86 views

Which is the best way to fix and preserve comet assay slides before staining with Ethidium Bromide?

I want to use the method of Single Cell Gel Electrophoresis (comet assay). I have many samples, but I don't have the appropriate microscope. So I have to preserve my slides until the time comes for ...
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22 views

Environmental Alkylating Agents [closed]

I am looking for the names of some environmental alkylating agents (in context of DNA damages) found for example in the fume produced by industry. Most of the papers which I have found is concentrated ...