Why is it that alpha-2 adrenoceptor agonists haven't been tried, in clinical trials, as an adjunct to PDE4 inhibitors?
Phosphodiesterase 4 (PDE4) inhibitors such as rolipram and piclamilast have demonstrated a number of potential therapeutic effects in preclinical studies and even the odd clinical study, but their ...
As far as I can tell, caffeine metabolism occurs primarily via the CYP1A2 enzyme. I am curious as to whether mutations in the CYP1A2 gene are associated with caffeine intolerance. Some site that is ...
Does the Enzyme Monoamine Oxidase, Isoenzyme A (MAO-A) have an allosteric modulatory site? I ask because I would like to know if it is possible, in theory at least, for a positive allosteric modulator ...
Which Enzymes Degrade Dynorphins and what drugs are there available to inhibit said enzymes?
I know that the non-steroidal anti-inflammatory drugs (e.g., aspirin, ibuprofen, naproxen) affect the enzymes cyclooxygenase (types I and II). Is there any difference in the degree to which these ...