Mechanisms for inheriting phenotype outside of the genomic DNA sequence.

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19
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1answer
364 views

Regulation of chromatin structure

Recently, I reviewed the different levels of chromatin structure. The primary level is nucleosomes, where DNA is bound to histones, and has structural similarity to "beads on a string." The secondary ...
18
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2answers
1k views

Can rats pass on memories of a maze to their offspring?

A friend of mine told me once about a documentary movie he saw some years ago. On this movie he saw scientists talking about particular experiment. This experiment involved rats and probably ...
15
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3answers
1k views

Transmission of epigenetic regulation through surrogate mother

I know the basics of epigenetics, but I do not know how epigenetic mechanisms are transmitted from parents to children (or if there is even enough literature to derive a consensus). My question is ...
15
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3answers
252 views

Defining paper(s) in epigenetics

For someone who is interested in learning about the discovery of epigenetics, which are the foundational defining papers in the area?
14
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2answers
223 views

Can methylation from DNA get copied to RNA during transcription?

Methylation on gene-body and 3'UTRs if copied to mRNA can potentially regulate post-transcription modifications or expression regulation. But I'm not sure if they are maintained after transcription or ...
12
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5answers
316 views

Is it the case that all changes in phenotype during life are not inheritable?

This came up in a talk with a friend. I wanted to clear this doubt. I've read about it before and did again after her remark (my thoughts didn't change: her concept is Lamarck's, not Darwin's), but ...
12
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1answer
326 views

How are epigenetic marks transmitted during cell division?

As far as I know, this is one of the biggest questions in the epigenetic field: how are the epigenetic marks like histone modifications propagated through cell division? A lot is already known about ...
11
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1answer
425 views

How do CpG islands remain unmethylated?

In most of the genome CpG sites are pretty much always methylated, but CpG islands are instead often unmethylated. This has been linked to the fact that they often are associated to transcripted ...
10
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1answer
533 views

Why is the 3'UTR region highly methylated in most of the human genes?

Most of the human genes are found to be highly methylated in their 3'UTR region (0.8-0.9%). I was wondering if there is any specific reason for this?
9
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3answers
103 views

Standard letter for 5-methylcytosine

I'm working on a piece of software that computes melting temperatures for nucleic acid duplexes, and I'm about to add support for 5-methylcytosine as a nucleotide base. At the moment, the bases ...
9
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1answer
133 views

What are the criteria for determining the influence of epigenetic factors?

Isolating a gene or sets of genes in diseases sometimes isn't enough to determine penetrance - epigenetic factors can have a significant effect. What are the criteria in determining whether epigenetic ...
8
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2answers
155 views

Are prions an important driver in evolution?

I understand that prions have been implicated in the passing on of epigentic information[1]. Are prions thought to play a significant role in the evolution of organisms? Alberti S, Halfmann R, King ...
4
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1answer
135 views

How does “inheritance of methylation” of DNA and/or histones work?

What are the current models/ideas describing the mechanisms explaining inheritance of methylation on DNA resp. histone level? Is there evidance of this "setup" information being really ...
3
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1answer
191 views

Can replication occur if DNA is methylated?

Can a methylated strand of DNA be replicated without removing methylation? Does it make any difference if the strand is methylated or not (during replication)?
3
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1answer
36 views

What is the purpose of back-crossing mice for multiple generations?

Occasionally I will come across articles that refer to back-crossing mice of one strain onto the background other another strain (e.g., C57Bl6). They do not explicitly state the purpose for doing so, ...
3
votes
1answer
66 views

How can chromatin state be measured?

I have some RNA-Seq data and I'd like to align it to the physical genome and see which sections of chromatin are geometrically open and being transcribed. The data are already sequence-aligned, and ...
3
votes
2answers
218 views

Short-term Lamarckism in asexual single cell organisms

I was reading through the Karr et al. (2012) whole-cell computational model. One of the things they did was to induce single-gene disruptions in their model. They observed several to be fatal, but: ...
3
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0answers
47 views

Literature about putative epigenetic state changes in mammal sequences after cloning steps in Escherichia coli

I would like you to point me out some literature about putative epigenetic state changes in mouse/mammal sequences after cloning steps in Escherichia coli. This are the last search details I used in ...
2
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2answers
1k views

What is genomic imprinting?

What is a genomic imprint? How does genomic imprinting take place? If I say that "this" allele is maternally imprinted does it mean that the allele of the gene is passed only by the mother? If a ...
2
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1answer
142 views

Can epigenetic changes affect reproductive success?

This is prompted by niallhaslam's answer to this question [Since Darwinian times, has there been any striking/notable effects of evolution on humans?]. A comment by Alan Boyd asks whether epigenetic ...
2
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1answer
124 views

Histone marks mechanism

I am slightly confused about the mechanisms that makes histone modifications associate with gene expression. That is, H3K36me3 is believed to be present in actively transcribed genes, H3K27me3 in ...
1
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1answer
69 views

Are there any studies of epigenetic difference between twins during their lifespan?

Are there any studies of epigenetic difference between twins during their lifespan ? I ask because I wonder if there exist phases during lifespan, when environmental factors plays major role ...
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2answers
50 views

Why is the human body hair not uniformly colored?

Most of my body hair is black however my lip hair is light brown/blonde the rest of my beard region is black. Since hair color is genetic what causes this?
1
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1answer
36 views

Omics integration questions [closed]

Let's say that I have a population of Mus musculus in the lab. I divide it in a control group and a test group. The test group is constantly subjected to a stress (example: elevated UV radiation). ...
1
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1answer
122 views

Why do I have a lot in common with my mother? [closed]

I have not spoken to my mother in 15 years but recently connected with her and her side of the family. I was primarily raised in a different sub-culture after the age of 4. As it turns out I ...
1
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1answer
40 views

psychological database with sequenced DNA records

I'm looking for an epigenetic database which includes for each example the psychological history of the persons DNA. Right now I can only find DNA and epigenetic databases. Sadly none of the databases ...
1
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1answer
129 views

Genetic Epistasis Question

I need help with this practice question. I'm assuming that would a epsitatic recessive question since the parents are true breeding and then the ratio would be 9.3.4. But I am not so sure. Any ...
1
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2answers
65 views

Is it possible to do chip-seq on a specfic region?

Is it possible to do Chip-Seq on specific region of the genome. The idea is to enrich before the sequencing step to have more sensitivity.
1
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1answer
57 views

Studying genetics [closed]

I am interested in studying disorders that are genetic in origin. However, I am having difficulty in understanding molecular and cellular mechanisms regarding processes such as meiosis, mitosis, and ...
1
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1answer
91 views

How might IVF (and related technologies) alter epigenetic marks?

I was reading up on KCNQ1, which encodes a voltage-gated potassium channel, and I discovered that it happens to be only maternally expressed. This is regulated by KCNQ1OT1, a non-coding RNA, which is ...
1
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0answers
32 views

If a receptor is inhibited throughout embryogenesis, could there be observable phenotypic differences in the adult?

So I read a journal article entitled "Maternal hypoxia and caffeine exposure depress fetal CV function during primary organogenesis" (Momoi, et al., 2012) and in essence the article speaks of the ...
0
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1answer
84 views

PedigreeAnalysis Genetics [duplicate]

Hello! I need help with this exercise question. I am not really sure which pedigree diagram is autosomal and which is not. But, is question b 1/2. Can someone give an explanation? Thanks very much ...
0
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0answers
32 views

Paracentric Inversion and Mutations Question Help Needed

Would someone please be able to help with questons 3 or 4. (one of the at least please) please don't report his as off-topic. first, this is NOT a homeowork question. It's a practice question I am ...