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1answer
10 views

R/Bioconductor query for a gene?

I'm fairly new to bioinformatics, so please be gentle ;0 Is there a way to query a particular gene using a script in R/Bioconductor? I'm particularly interested in Gene Ontology terms. There are ...
1
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1answer
71 views

What exactly are genes, DNA and chromosomes. How do they relate to each other and what is their function? [closed]

So I am new to biology and I have been reading, and searching the web, but I couldn't understand the whole framework of a cell. So as I understood: A DNA, is a double chain of Nucleotides (A,T,G,C ...
5
votes
1answer
36 views

How allele is related to trait that is more complex than two cases (ex. height)?

Recently I started to learn about evolution and genetics. Simple stuff at the beginning - some videos, some reading. So far, everything seems to be pretty simple and straightforward. I easily grasp ...
4
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2answers
33 views

How do I know whether or not a nuclear gene is single copy?

As a part of a phylogenetic study, I need to find a nuclear gene that meets the following requirements: Single copy gene; Highly variable gene; Gene longer than 400 bps; Gene that gives information ...
3
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2answers
147 views

Genetic mutations and new alleles

Amongst silent, nonsense and missense genetic mutations, is the latter the only one that leads to the creation of new alleles? If we define alleles as a specific form of a gene, and a gene as a ...
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2answers
36 views

How do biologists quantify “gene expression” in experiments?

I've read papers which contain statements such as "control of gene expression is critical in biological processes". How exactly does one quantify "gene expression"? Isn't gene expression an umbrella ...
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0answers
41 views

What further research can the result of gene variation detection be used for [closed]

We do a research on a particular cancer (for e.g. breast cancer). Now, we have a result for the gene variation detection (VCF file). What next steps do we need to do? We don't have a clear picture ...
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2answers
64 views

Which strand of a gene specifies a protein? [closed]

A gene is a segment of DNA (I hope double stranded) and each strand when transcribed form a mRNA and after being translated a protein. As from each gene there are two proteins that are being formed. ...
6
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1answer
235 views

Is there any virus that contains both DNA and RNA in its genome?

It is known that viruses contain DNA or RNA- either one and not both. I came across a question: Which virus contains both DNA and RNA?
0
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1answer
37 views

Get Parent GO terms of GO term vector?

I have a vector of GOIDs that are specific GO IDs outputted from an enrichment analysis. I want to cluster my GOIDs by their parent GOID term. I used GOstats to do my enrichment analysis, and I have ...
1
vote
1answer
41 views

Yeast Strain with squalene synthase / farnesyltransferase (ERG9) gene deleted

I was interested in obtaining a yeast strain without the enzyme farnesyltransferase (Which catalyses conversion of FPP to Squalene). The Euroscraf database has thousands of yeast strains with ...
0
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1answer
20 views

Genomic distribution of tRNAs in eukaryotes

The title says it all. I'm doing a literature search trying to see what is widely known and/or well established. I've found a couple of mentions that tRNAs are dispersed throughout the entire nuclear ...
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2answers
46 views

How long does it take for a person to lose all offsprings due to inheritance?

From this I know we will only inherit some genetic informations from parents, which is about 50 percent. But the problem is, gene has finite size, after some generations a person leaves only $0.5 \...
-4
votes
1answer
75 views

Why do we have oncogenes? [closed]

Oncogene is a gene which in certain circumstances can transform a cell into a tumour cell. Everything we have has reason and meaning. Or there was some use in past. What's the reason for we have ...
4
votes
1answer
77 views

What happens if there is a blood incompatibility during pregnancy?

There are possible combinations of blood types with the rH factors: Rh factors are genetically determined. A baby may have the blood type and Rh factor of either parent, or a combination of both ...
1
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1answer
36 views

Creation of healthy genetically modified crops [closed]

GM crops are huge at the moment, and the noticeable 'counter movement' is for people to continue to purchase organic foods (please note I am specifically talking of GM crops and not meats, etc). The ...
0
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2answers
48 views

Does a gene that regulates itself necessarily be a transcription factor?

I am not a biologist, so please pardon the overly noob question. Some genes are transcription factors (TF) and regulate other genes. My question is: if a gene is NOT a TF gene, can it regulate itself? ...
3
votes
2answers
343 views

Gene and alleles

This is a multiple choice question: Consider a gene, ABC, which codes for an enzyme involved in the metabolism of sugars. There are two known alleles of this gene, ABC1 and ABC2. Which statement ...
0
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1answer
76 views

How can I find the most studied SNP of a gene?

How can I find the most studied SNP of a gene and diseases that the most studied SNP has been related to? I search in dbSNP database but I can't find it. What is the process?
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2answers
40 views

Non-descriptive gene nomenclature

I formally come from a physics/physical chemistry background, but I have begun to specialize in the area of the biomedical sciences and biomedical engineering. I found myself reading an article which ...
0
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1answer
48 views

Understanding different genetic terminology - Genotype vs SNP

I recently came across a study that refereed to variations in genes like this: IGF1 (CA)19/(CA)19, IGF1(CA)19/X, IGF1 X/X (From this study: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274549/) I ...
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0answers
51 views

Sexual selection and genotypes [closed]

I have question about genetics and sexual selection. This is re-worded from a problem that was posed to help me and others understand what is going on here. Say you have a fictional species on an ...
4
votes
1answer
81 views

Why aren't gene drives extremely common?

The ability for gene drives to sidestep the Mendelian mechanism and rapidly spread through populations (even if the gene is slightly fitness reducing) is extremely powerful. Why aren't normal ...
1
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0answers
55 views

How to find name of the gene

Considering the kegg page, this page contains the description of the gene Edwardsiella tarda EIB202: ETAE_0074 . Now this gene has a name given in the page as : wabG. Now considering another gene 1 ...
5
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2answers
45 views

Animal gene in plants

Usually only microbes, specifically bacteria are used to express genes of other species for various functions. But, it is possible to try and express an animal gene into a plant. Bacteria like ...
1
vote
1answer
46 views

Query from a ppt slide

I came across this slide: Now I haven't understood what the last two grey colored lines mean. Can't ORFS be of any size? What is overlapping frames here?
0
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0answers
13 views

Gene Therapy for P50 mutations

I was wondering if it is possible to use gene therapy to fix mutations in the p50 gene. I know this gene when mutated leads to various forms of cancers, so can gene therapy be used to fix this? Or are ...
0
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0answers
20 views

Organ secretions

If an animal secrets an enzyme from an organ that is entirely dedicated for the same secretion, can one or cannot one just use the gene coding for that protein to obtain the protein in vitro. How much ...
0
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1answer
56 views

Common genes and enzymes involved in pathogen entry into host

Many microbes like Salmonella, E.coli, Legionella pneumophila etc. enter host cells via cystoskeleton remodeling of the host cell. Do all microbes follow the same path or there are any other ways for ...
1
vote
0answers
81 views

How to identify a pseudogene to a specific protein coding genes?

Pseudogenes are those sequences in the genome that bear similarity to specific protein coding genes, but nevertheless are unable to produce functional proteins due to existence of frameshifts, prema- ...
1
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2answers
906 views

Are eukaroytic promoters located in the 5' UTR region?

I was wondering if promoter sequences are located on 5'UTR region in eukaryotic organisms?
0
votes
1answer
63 views

IBD-value in pedigree with inbreeding

I have a question about IBD. Please see the figure below. How many pairs of alleles are IBD for X and Y, or what is the IBD value for X and Y. Is it four (4)? I have seen it to be maximally 2, but ...
1
vote
1answer
25 views

What is the convention for indicating genomic primer sites?

What is the most common notation for indicating genomic binding sites of primers relative to an ORF? For instance, if I want to indicate a primer like so: ...
1
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1answer
53 views

genes map to eQTL/pQTL

Of the 192 target genes, 79 map to a significant eQTL or pQTL in at least one dietary condition. is the line for a paper "Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a ...
1
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2answers
60 views

Are genes on the 5' to 3' strand only?

I confused myself during studying, and wanted to confirm something. Since transcription via RNA polymerases only takes place in the 5'to 3' direction, that would mean that that 5' to 3' strand is the ...
1
vote
1answer
529 views

Doubts regarding definition of upstream/downstream genes and cognate protein

With respect to the research paper, there are a few things I didn't understand: 1. What is upstream and downstream gene 2. This paper identifies proteins that help in secretion, but does not identify ...
1
vote
1answer
130 views

Please explain what a gene isoform is in lay terms?

I am a physicist by training, however I am now doing computational biology research. I know what genes, DNA, proteins, enzymes, introns and exons are. I sort of understand how DNA is used to create ...
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0answers
23 views

GO term for orthologous gene IDs

I have a list of orthologous gene IDs from the first supplementary file in here. The gene IDs are of the following type: ...
1
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1answer
80 views

Chimeric Gene vs Fusion Gene?

According to wikipedia on chimeric genes: These mutations are distinct from fusion genes which merge whole gene sequences into a single reading frame and often retain their original functions. ...
2
votes
1answer
41 views

Map gene IDs to Ensembl gene ID

Forgive me if this question is too trivial. I have the gene IDs of the following type EOG6STSR2 EOG60ZRJB EOG6SBFJ2 EOG6P5KX3 EOG6B5PRW from the first ...
0
votes
1answer
57 views

Critical discussion: Gene expression and systems biology allows us to understand the control of complex traits

I'm having a bit of trouble tackling this question. Any help on what I should write about or the points I should mention would be much appreciated. I keep seeing articles about eQTL and QTL are these ...
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3answers
190 views

Immortality Gene? Really? [closed]

I read somewhere in the internet and wondered if human genes have deactivated immortality genes locked somewhere in the DNA strand. Is this statement true? What does it mean for human lifespan?
1
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0answers
39 views

His Tag location in gene circuit

I am part of an undergraduate research group and we are trying to produce a protease in an E.coli gene circuit. We are not sure where to place the His tag in our circuit. The sequence is ...OmpA(gene)-...
5
votes
1answer
687 views

What does it mean to “map the human genome”

I know some elementary chemistry and biology. I also think I know what a gene is (it's a sequence of DNA which encodes a particular protein). I also know that on a chromosome there are sections of DNA ...
2
votes
2answers
192 views

Why can't this be 1st meiotic division non-disjunction as well?

The child has gotten 2 "sick" chromosomes from his dad and 1 healthy from his mom, leaving it with trisomy 13. I can see how this can happen in the second meiotic division of the father but I can ...
0
votes
1answer
127 views

What does this mutation notation mean: MAP2K41161fs*12

I received a report that had a mutation notated as: "MAP2K41161fs*12". I'm used to seeing this sort of thing: BRAF(V600E) or BRAF(T1799TA). Can someone tell me how to interpret "MAP2K41161fs*12" ?? Is ...
0
votes
1answer
43 views

One Gene and many proteins [closed]

Imagine a gene with $n$ exons and $m$ introns. How many proteins are possible from that gene? Would all the proteins be isoforms?
0
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0answers
37 views

minimum ratio of the shortest isoform to the longest one derived from one same parent gene

I want to know what is the minimum percentage of the shortest isoform/transcript to the longest one that derived from the same parent gene? Does it have organism specificity? What is the function of ...
2
votes
1answer
202 views

Recessive alleles at Hardy-Weinberg equilibrium

I've run into a question that I disagree with others on but I would like to receive the input of others. The question is: If a population is at Hardy-Weinberg equilibrium, which of the following can ...
1
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2answers
3k views

Stop codons and exons?

If we had a hypotheical gene called gene exampleGene and this gene had 5 exons, labeled A, B, C, D, and E in that order on the chromosome, could it be the case that the stop codon for this gene be on ...