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+50

Why does human chromosome 19 have the second highest number of protein-coding genes?

While chromosome 19 only is the 19th largest autosomal chromosome, it contains 1440 protein-coding genes, and thus has the second highest number of protein-coding genes of any human chromosome. For ...
0
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0answers
22 views

Bio Project, Housekeeping promoters, high C-G count, vs tissue specific?

I have a research biology project to do, one part that I'm doing is essentially comparing the sequences of different organisms and based on the sequences am describing whether that gene has a ...
0
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2answers
28 views

What amount of genes co-expressed should be expected in a tissue?

I am working with gene expression microarrays of tumor tissues and I want to use a program to find the clusters of co-expressed genes in order to know if some particular genes are co-expressed with ...
0
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3answers
48 views

Passing on Alleles

Just a basic question on alleles, I am just trying to learn the basic concepts. So if we are to screen two parents, both with one dominant and one recessive allele for a given characteristic e.g. eye ...
0
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0answers
5 views

Delta Mye and F/F after gene name

What do the delta Mye and F/F mean? For example in the following figure (https://www.researchgate.net/figure/45695903_fig5_Figure-2-Enhanced-plasma-inflammatory-cytokines-in-GRK2mye-mice-Mice-were-...
0
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2answers
38 views

R/Bioconductor query for a gene?

I'm fairly new to bioinformatics, so please be gentle ;0 Is there a way to query a particular gene using a script in R/Bioconductor? I'm particularly interested in Gene Ontology terms. There are ...
1
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1answer
78 views

What exactly are genes, DNA and chromosomes. How do they relate to each other and what is their function? [closed]

So I am new to biology and I have been reading, and searching the web, but I couldn't understand the whole framework of a cell. So as I understood: A DNA, is a double chain of Nucleotides (A,T,G,C ...
5
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1answer
38 views

How allele is related to trait that is more complex than two cases (ex. height)?

Recently I started to learn about evolution and genetics. Simple stuff at the beginning - some videos, some reading. So far, everything seems to be pretty simple and straightforward. I easily grasp ...
4
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2answers
40 views

How do I know whether or not a nuclear gene is single copy?

As a part of a phylogenetic study, I need to find a nuclear gene that meets the following requirements: Single copy gene; Highly variable gene; Gene longer than 400 bps; Gene that gives information ...
3
votes
2answers
150 views

Genetic mutations and new alleles

Amongst silent, nonsense and missense genetic mutations, is the latter the only one that leads to the creation of new alleles? If we define alleles as a specific form of a gene, and a gene as a ...
1
vote
2answers
38 views

How do biologists quantify “gene expression” in experiments?

I've read papers which contain statements such as "control of gene expression is critical in biological processes". How exactly does one quantify "gene expression"? Isn't gene expression an umbrella ...
1
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0answers
42 views

What further research can the result of gene variation detection be used for [closed]

We do a research on a particular cancer (for e.g. breast cancer). Now, we have a result for the gene variation detection (VCF file). What next steps do we need to do? We don't have a clear picture ...
0
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2answers
64 views

Which strand of a gene specifies a protein? [closed]

A gene is a segment of DNA (I hope double stranded) and each strand when transcribed form a mRNA and after being translated a protein. As from each gene there are two proteins that are being formed. ...
6
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1answer
287 views

Is there any virus that contains both DNA and RNA in its genome?

It is known that viruses contain DNA or RNA- either one and not both. I came across a question: Which virus contains both DNA and RNA?
0
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1answer
43 views

Get Parent GO terms of GO term vector?

I have a vector of GOIDs that are specific GO IDs outputted from an enrichment analysis. I want to cluster my GOIDs by their parent GOID term. I used GOstats to do my enrichment analysis, and I have ...
1
vote
1answer
43 views

Yeast Strain with squalene synthase / farnesyltransferase (ERG9) gene deleted

I was interested in obtaining a yeast strain without the enzyme farnesyltransferase (Which catalyses conversion of FPP to Squalene). The Euroscraf database has thousands of yeast strains with ...
0
votes
1answer
20 views

Genomic distribution of tRNAs in eukaryotes

The title says it all. I'm doing a literature search trying to see what is widely known and/or well established. I've found a couple of mentions that tRNAs are dispersed throughout the entire nuclear ...
0
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2answers
47 views

How long does it take for a person to lose all offsprings due to inheritance?

From this I know we will only inherit some genetic informations from parents, which is about 50 percent. But the problem is, gene has finite size, after some generations a person leaves only $0.5 \...
-4
votes
1answer
84 views

Why do we have oncogenes? [closed]

Oncogene is a gene which in certain circumstances can transform a cell into a tumour cell. Everything we have has reason and meaning. Or there was some use in past. What's the reason for we have ...
4
votes
1answer
84 views

What happens if there is a blood incompatibility during pregnancy?

There are possible combinations of blood types with the rH factors: Rh factors are genetically determined. A baby may have the blood type and Rh factor of either parent, or a combination of both ...
1
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1answer
46 views

Creation of healthy genetically modified crops [closed]

GM crops are huge at the moment, and the noticeable 'counter movement' is for people to continue to purchase organic foods (please note I am specifically talking of GM crops and not meats, etc). The ...
0
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2answers
48 views

Does a gene that regulates itself necessarily be a transcription factor?

I am not a biologist, so please pardon the overly noob question. Some genes are transcription factors (TF) and regulate other genes. My question is: if a gene is NOT a TF gene, can it regulate itself? ...
3
votes
2answers
345 views

Gene and alleles

This is a multiple choice question: Consider a gene, ABC, which codes for an enzyme involved in the metabolism of sugars. There are two known alleles of this gene, ABC1 and ABC2. Which statement ...
1
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1answer
81 views

How can I find the most studied SNP of a gene?

How can I find the most studied SNP of a gene and diseases that the most studied SNP has been related to? I search in dbSNP database but I can't find it. What is the process?
1
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2answers
41 views

Non-descriptive gene nomenclature

I formally come from a physics/physical chemistry background, but I have begun to specialize in the area of the biomedical sciences and biomedical engineering. I found myself reading an article which ...
0
votes
1answer
50 views

Understanding different genetic terminology - Genotype vs SNP

I recently came across a study that refereed to variations in genes like this: IGF1 (CA)19/(CA)19, IGF1(CA)19/X, IGF1 X/X (From this study: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274549/) I ...
1
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0answers
52 views

Sexual selection and genotypes [closed]

I have question about genetics and sexual selection. This is re-worded from a problem that was posed to help me and others understand what is going on here. Say you have a fictional species on an ...
4
votes
1answer
81 views

Why aren't gene drives extremely common?

The ability for gene drives to sidestep the Mendelian mechanism and rapidly spread through populations (even if the gene is slightly fitness reducing) is extremely powerful. Why aren't normal ...
1
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0answers
55 views

How to find name of the gene

Considering the kegg page, this page contains the description of the gene Edwardsiella tarda EIB202: ETAE_0074 . Now this gene has a name given in the page as : wabG. Now considering another gene 1 ...
5
votes
2answers
46 views

Animal gene in plants

Usually only microbes, specifically bacteria are used to express genes of other species for various functions. But, it is possible to try and express an animal gene into a plant. Bacteria like ...
1
vote
1answer
46 views

Query from a ppt slide

I came across this slide: Now I haven't understood what the last two grey colored lines mean. Can't ORFS be of any size? What is overlapping frames here?
0
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0answers
13 views

Gene Therapy for P50 mutations

I was wondering if it is possible to use gene therapy to fix mutations in the p50 gene. I know this gene when mutated leads to various forms of cancers, so can gene therapy be used to fix this? Or are ...
0
votes
0answers
20 views

Organ secretions

If an animal secrets an enzyme from an organ that is entirely dedicated for the same secretion, can one or cannot one just use the gene coding for that protein to obtain the protein in vitro. How much ...
0
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1answer
57 views

Common genes and enzymes involved in pathogen entry into host

Many microbes like Salmonella, E.coli, Legionella pneumophila etc. enter host cells via cystoskeleton remodeling of the host cell. Do all microbes follow the same path or there are any other ways for ...
1
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0answers
83 views

How to identify a pseudogene to a specific protein coding genes?

Pseudogenes are those sequences in the genome that bear similarity to specific protein coding genes, but nevertheless are unable to produce functional proteins due to existence of frameshifts, prema- ...
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2answers
981 views

Are eukaroytic promoters located in the 5' UTR region?

I was wondering if promoter sequences are located on 5'UTR region in eukaryotic organisms?
0
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1answer
65 views

IBD-value in pedigree with inbreeding

I have a question about IBD. Please see the figure below. How many pairs of alleles are IBD for X and Y, or what is the IBD value for X and Y. Is it four (4)? I have seen it to be maximally 2, but ...
1
vote
1answer
25 views

What is the convention for indicating genomic primer sites?

What is the most common notation for indicating genomic binding sites of primers relative to an ORF? For instance, if I want to indicate a primer like so: ...
1
vote
1answer
56 views

genes map to eQTL/pQTL

Of the 192 target genes, 79 map to a significant eQTL or pQTL in at least one dietary condition. is the line for a paper "Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a ...
1
vote
2answers
60 views

Are genes on the 5' to 3' strand only?

I confused myself during studying, and wanted to confirm something. Since transcription via RNA polymerases only takes place in the 5'to 3' direction, that would mean that that 5' to 3' strand is the ...
1
vote
1answer
570 views

Doubts regarding definition of upstream/downstream genes and cognate protein

With respect to the research paper, there are a few things I didn't understand: 1. What is upstream and downstream gene 2. This paper identifies proteins that help in secretion, but does not identify ...
1
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1answer
143 views

Please explain what a gene isoform is in lay terms?

I am a physicist by training, however I am now doing computational biology research. I know what genes, DNA, proteins, enzymes, introns and exons are. I sort of understand how DNA is used to create ...
1
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0answers
23 views

GO term for orthologous gene IDs

I have a list of orthologous gene IDs from the first supplementary file in here. The gene IDs are of the following type: ...
1
vote
1answer
81 views

Chimeric Gene vs Fusion Gene?

According to wikipedia on chimeric genes: These mutations are distinct from fusion genes which merge whole gene sequences into a single reading frame and often retain their original functions. ...
2
votes
1answer
42 views

Map gene IDs to Ensembl gene ID

Forgive me if this question is too trivial. I have the gene IDs of the following type EOG6STSR2 EOG60ZRJB EOG6SBFJ2 EOG6P5KX3 EOG6B5PRW from the first ...
0
votes
1answer
57 views

Critical discussion: Gene expression and systems biology allows us to understand the control of complex traits

I'm having a bit of trouble tackling this question. Any help on what I should write about or the points I should mention would be much appreciated. I keep seeing articles about eQTL and QTL are these ...
-1
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3answers
191 views

Immortality Gene? Really? [closed]

I read somewhere in the internet and wondered if human genes have deactivated immortality genes locked somewhere in the DNA strand. Is this statement true? What does it mean for human lifespan?
1
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0answers
39 views

His Tag location in gene circuit

I am part of an undergraduate research group and we are trying to produce a protease in an E.coli gene circuit. We are not sure where to place the His tag in our circuit. The sequence is ...OmpA(gene)-...
5
votes
1answer
697 views

What does it mean to “map the human genome”

I know some elementary chemistry and biology. I also think I know what a gene is (it's a sequence of DNA which encodes a particular protein). I also know that on a chromosome there are sections of DNA ...
2
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2answers
197 views

Why can't this be 1st meiotic division non-disjunction as well?

The child has gotten 2 "sick" chromosomes from his dad and 1 healthy from his mom, leaving it with trisomy 13. I can see how this can happen in the second meiotic division of the father but I can ...