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Immediate Early Genes during sleep

In Neuroscience 3rd ed by Bear et al. on page 607, immediate early genes are described as related to changing synaptic strength, yet have decreased expression during sleep. The explanation given is ...
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CRISPR Knock in

Using the CRISPR/Cas9 technology, it is possible that after inducing a DSB with the Cas9 endonuclease guided with an RNA designed by the user and using a template DNA, get a desired Knock-In (KI) by ...
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Can methylation of a promoter induce gene expression in some rare cases?

Can methylation of a promoter induce gene expression in some rare cases? I've read somewhere that methylation of an intron can induce gene expression (eg. Igf2). How is that even possible? Thank ...
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Mode of Enzymatic Inhibition via R-Allele

The photo above shows the effects of the R allele of the pea shape gene on the synthesis of an enzyme that converts unbranched starch into branched starch. The r allele of this gene determines an ...
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What to do if microarray t-test, ANOVA, SAM and LImma show various selected significant genes?

Need advice: how to approach discrepancy in differential microarray gene expression test results: what to do if ANOVA, ttest, SAM and Limma procedures show different results and especially more ...
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Father with mutated gene for mtDNA- why isn't his offspring at risk?

Mothers transmit their mitochondria (and therefore mtDNA) to their offspring and fathers don't. Lets assume that father had a mutation of the gene that encodes mtDNA, would then be his offspring at ...
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What does the gene name “lexA” stand for?

It is an important gene expressed in E. coli that represses the SOS response and also the expression of lambda lytic phase genes. UV light and damage to DNA is responsible for its breakdown and hence ...
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Why we do not use RNAi to control ebola?

As you know using RNAi we are able to prevent gene expression. so why we do not use it to stop viral genes expression?