The processes by which gene products (largely RNA and proteins) are increased or decreased
5
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1answer
32 views
What regulates these two methods of splicing?
Alternative splicing can shuffle the exon order and select from the exon sequence of a single gene site to provide a combinatorial selection of possible transcription products from the one gene. Can ...
9
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2answers
104 views
Modularity of transcription factors
I attended a seminar about neurogenesis that presented results for PAX6 as an important TF that contains 3 domains with very distinct patterns of downstream expression. The speaker ended up saying ...
1
vote
1answer
31 views
How to determine the direction of regulation of a gene by comparing gene expressions?
I am just learning about the gene expressions and regulation. Several researches focus on finding the genes of altered gene expressions on a microarray to claim that they have a correlation to a ...
3
votes
1answer
42 views
mutant down but not out
I am interested in a gene which is null lethal but I need to temporary induce diminished capacity. If a cell is homozygous is it possible to induce heterozygous phenotypes or a partial knockout from ...
5
votes
1answer
62 views
DNA methylation and genome size
Is there any relationship between DNA methylation as a level of stability to epigenetic states and genome size? For example, it is claimed that DNA methylation is not required for epigenetic stability ...
5
votes
2answers
46 views
tools to reconstruct the transcriptional regulatory circuits?
What are commonly used tools to reconstruct the transcriptional regulatory circuits that govern diverse cellular responses and what input data sets do they accept?
8
votes
2answers
424 views
Databases for gene regulatory network graphs?
What databases are available for gene regulatory network graphs starting from a given gene? For example, starting from p53 gene, where can I find a gene regulatory network image that can be exported ...
13
votes
2answers
194 views
Percentage of genome devoted to regulating gene expression
Recently I've been studying the p53 tumor suppressor gene as a model for regulation of gene expression. It's amazing how many different post-translational modifications are known to regulate p53 ...
7
votes
1answer
65 views
How do nuclear receptors locate each other to form a DNA loop?
Nuclear receptors can influence transcription far up- or downstream from their own binding sites by looping DNA (Rubina et al.; J Mol Bio 2004).
I am not sure how exactly the receptors first attach ...
