Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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University genetics human pedigree problem. Check my answers?

The pedigree below is of a rare hereditary disease of the nervous system: a. Is it recessive or dominant? Explain. ...
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What's the mechanism or structure responsible for new species genetic code generation?

I always had this question in mind. I think, If humans find answer to it then we can trigger the next evolution of human specie. What is the mechanism or structure responsible for evolution ? I don't ...
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Follow-up to The Red Queen by Matt Ridley? [on hold]

I just finished reading The Red Queen: Sex and the evolution of human nature by Matt Ridley. Since this book is over 20 years old, I was wondering if more recent research made part of the book ...
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Obtaining a mapping of RefSeq ACs to Uniprot ACs

I am trying to obtain a mapping for RefSeq Accession Numbers to Uniprot Accession Numbers. I can write a script to do this for a list of RefSeq ACs like this: ...
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Difference between genetic adaptability and micro evolution? [on hold]

Do both occur at individual level? And which among the two is responsible for a species to maintain its specificity?
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What is the definition of a mutation?

There are two alleles that determine the sensitivity of a person to Coumadin (a medicine for blood thinners used to treat a stroke etc). Sometimes you encounter the terminology that one has a mutation ...
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Distinguishing Father from Brother

Given the (non-identical) DNA sequences of two men and the knowledge that the second man is either the father, brother, or son of the first man, is the DNA useful in determining which of these three ...
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What separates gene loci?

Introns are sections of noncoding DNA that separate exons within a gene locus. However, between different gene loci, I also would assume there to be noncoding regions of DNA. What are these regions ...
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Crossing over and exon shuffling?

Campbell Biology 10e, in discussing the functions of introns, writes: The presence of introns in a gene may facilitate the evolution of new and potentially beneficial proteins as a result of a ...
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How should one interpret heritability? Is it related to $R^2$?

From Wiki: Heritability estimates are often misinterpreted if it is not understood that they refer to the proportion of variation between individuals on a trait that is due to genetic factors. It ...
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Is the DNA different in each type of cell? What DNA is passed to offspring?

Our body contains many different types of cells and each of those cells have their own DNA (correct me if wrong) like skin cells their own DNA that makes them skin cells instead of muscle cells. So ...
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Solving a Pedigree Between Heterozygous Half-Cousins

A man who is a known heterozygous carrier of oculocutaneous albinism marries his half-cousin (they share one common grandparent) as shown in the pedigree below. This trait is transmitted as a fully ...
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What does characterization mean in a genomics context?

"The resulting libraries of gene sequences allow CDC and other laboratories to compare the genes of currently circulating influenza viruses with the genes of older influenza viruses and viruses ...
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XNAs as a Genetic material [closed]

I heard there is a new genetic material called XNAs.I wanted to know more about this.Does anyone about XNAs as genetic material?
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Why does maximum likelihood rarely use morphological data? [closed]

ML uses Dna rather than morphological data most of the time, unlike parsimony. I was just wonder why this is the case
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Is the relative amount off junk DNA a measure of an organisms complexity? [closed]

A rice plant contains as much active DNA (protein coding) as a human being. Can this be a sign that the more junk DNA the nucleus of a cell contains, the more complex the organism is that develops?
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Gene centromere distance in yeast tetrads

I'm not getting the formula for calculating distance between a centromere and a gene in a Neurospora tetrad. Formula: Distance(gene to centromere)= 100 * 0.5(tetrads showing MII segregation)/(total ...
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Amplified Fragment Lenth Polymorphism (AFLP) primers

I am trying to blast AFLP primer sequences to the genome to find the locations of the AFLP markers. However, I can't seem to find full alignments for the primers on the genome. For example, in the ...
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Explain allelic complementation at molecular level

I know that Allelic complementation is a phenomenon where two recessive loss-of-function allele generate a functional gene product by compensating each others' defect. But I don't get how do they ...
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Are scientist able to correct mutiple gene defect in our body by using CRISPR

Are scientist able to correct mutiple gene defect in whole body by using CRISPR recently? AS i know, it is in a beginning stage
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Was the frequency of mutations more during primitive earth due to radioactivity?

Primitive earth was more radioactive (or was it really?) according to radiometric analysis of C14 which suddenly appeared at 4250 million years in the Hadeon eon. Is it possible that ancient high ...
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RAD sequencing: choosing the appropriate enzyme?

I’m studying Darwin’s finches genome and I say in some articles that the researchers used restriction enzymes to cut the DNA in their double digest RAD protocol. They are using EcoRI and MseI (GAATTC ...
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35 views

Can heritability be deduced from a correlation coefficient?

I am trying to understand the concept of heritability and from what I can gather, the heritability of a factor (say birth weight) must be closely related to the correlation coefficient of that factor ...
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Growth factors vs. mitogens

According to Campbell Biology, A growth factor is a protein released by certain cells that stimulates other cells to divide. and according to Wikipedia, A mitogen is a chemical substance ...
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Incomplete dominance with gain-of-function allele

Can somebody site an example of incomplete dominance with gain-of-function mutation?
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Genetic coding question, amino acid to base relationship

I'm studying for a test and I am confused by these problems/statements. How many amino acids will 18 bases code for? Answer: 6. I got this right. If a certain complete protein has 33 amino acids ...
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BWA-MEM single strand or doublestrand alignment

In whole genome secondary analysis does BWA-MEM use a double stranded fasta reference or are reads aligned to only one, single stranded fasta reference?
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“Heterozygotic expection” - when heterozygote differs from both homozygotes, but homozygotes are similar

For simple 2-alleles genetic model {a,A} and corresponding quantitative trait Q is typically true that Q(aa)>=Q(aA)>=Q(AA) or conversely Q(AA)>=Q(aA)>=Q(aA). For example, dominance means that ...
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Comparing genetics [closed]

Compare the possible effect on an individual of knowing that they have genes predisposing them to type-2 diabetes and the dominant allele that causes Huntington's disease. I am not sure about the way ...
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What is working definition for female infertility?

I've studied infertility and found that its quite complex to define. However, I came to know about a useful working definition of infertility; which was " Failure to achieve pregnancy". Few days later ...
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36 views

Why do Major and Minor grooves exist in dna strands? [closed]

I've been trying to find what causes the periodic appearance of major and minor grooves in DNA but have not yet been successful. Geometrical explanations would also be appreciated as I cannot ...
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318 views

Gene and alleles

This is a multiple choice question: Consider a gene, ABC, which codes for an enzyme involved in the metabolism of sugars. There are two known alleles of this gene, ABC1 and ABC2. Which statement ...
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How difficult is it to make a shRNA/miRNA/siRNA to silence/knockdown NaV1.7 voltage gated sodium channels in humans?

There have been various research projects that experimented with shRNA/miRNA/siRNA to specifically silence/knockdown NaV1.7 voltage gated sodium channels in small animals like rats & guinea pigs. ...
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Is HSV-vector-mediated miRNA expression in dorsal root ganglia stable?

My question is on the following article: "Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy" My question is, do ...
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How to identify genes in Ralstonia that synthesize PHB and promote granule formation?

The compound polyhydroxybutyrate (PHB) is of considerable industrial interest as a biodegradable substitute for plastic. PHB is synthesized from glycerol by the bacterium Ralstonia eutropha. PHB ...
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How was gene therapy able to CURE some diseases (I guess on cells that do NOT regenerate)?

Here's where I'm getting confused... I thought that gene therapy, when done on target cells that regenerate themselves constantly, can be effective for a limited time only (aka. The achieved effect ...
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The Semi-Conservative Model of DNA Replication: Question

My Campbell's Biology textbook contains the following diagram related to the semi-conservative model of DNA replication proposed by Watson and Crick. I have highlighted where my confusion arises in ...
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Simple Mendelian sex-linked chromosome fruit fly question

From my molecular biology textbook: When red-eyed flies (dominant) were mated with white-eyed flies (recessive), most, but not all, of the F1 progeny were red eyed. Furthermore, when the red-eyed ...
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Constant or variable number of chiasmata during recombination?

During recombination, is the number of chiasmata consistent for each gamete and are the chiasmata regions consistent within a single organism?
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Problem: What is this pattern of inheritance?

The following question was on a pretest of mine, and I'm trying to figure out the answer using what we've learned about Mendelian and non-Mendelian patterns of inheritance. I'm struggling quite a lot ...
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Why does the proportion of transposable elements vary so much across species?

Intuitively, transposable elements (TEs) are harmful as they may cause genome instability. However, some people argue that TEs are also sources of variations, especially regulatory sequences[1]. If ...
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Do only one or both pairs of homologous chromatids exchange genetic material during the process of crossing over?

To be specific: Assume chromosomes A and B are homologous. They've both replicated into A1, A2 and B1, B2 and have formed a tetrad at the equator (synapsis). Most textbooks show either A1 and B1 OR A2 ...
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What distinguishes Mendelian Inheritance from Non-Mendelian Inheritance?

I'm having some trouble determining what exactly is the difference between Mendelian inheritance and non-Mendelian inheritance. For instance, I understand that chromosomal abnormalities such as Down's ...
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Why is a heritability coefficient not an index of “how genetic” something is?

On his blog, Eric Turkheimer writes: [T]aken as a number, a unit of analysis, heritability coefficients are funny things to aggregate on such a massive level. What exactly are we supposed to ...
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What is allelic effect sizes and direction?

In a paper, Berkley, C. A., and C. Lexer. 2008. Admixture as the basis for genetic mapping. Trends in Ecology & Evolution 23:686–694, the definition of Genetic ...
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Pedigree Analysis: Problem

I'm struggling to arrive at the answer to the following question, which appeared on a pre-test of mine and which I am now using to study the material we've learned. According to this helpful video, I ...
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How the chaotropic agents help in purification of DNA molecule?

Those plants which are rich in secondary metabolites and polysaccharides DNA isolation can be done using certain chaotropic agents? can any one explain how it works?
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Are the genes for transcriptional factors close to their targets in the genome?

Transcriptional factors (activators and repressors) are proteins which regulate transcription. Being proteins, they themselves are also made from expression of certain DNA sequences/genes. For ...
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Is an egg classified based on the species inside it, or by the species that laid it?

Basically what I'm asking is if an animal of species x were to lay an egg, and the animal inside that egg happened to be the first member of a genetically new ...
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Why only human have noticeable difference in face? [duplicate]

Our facial appearance is pretty much different from each other unless we are talking about twin. Credit goes to crossing over of chromosome. But why can't we distinguish between other animals of same ...