Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Multiplex PCR, shorter amplicon inhibiting longer amplicon?

I want to run multiplex PCRs for my genotyping, with a primer pair targeting my construct and a primer pair targeting some housekeeping gene (sort of a built-in control). I designed the control ...
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1answer
22 views

Identify chromosome location from gene nucleotide or amino acid number

I'm sure this is a basic question, but I couldn't find an answer anywhere. Let's say I'm provided with the location of an amino acid or a nucleotide (for example, which lists the location as the ACADM ...
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28 views

Ways to efficiently design research projects in biology for a beginner? (genetics) [on hold]

I get to do research with my professor in the summer, and the vague direction he let me go in was DNA degradation. I want to help myself and him in designing a research strategy/project on this topic, ...
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1answer
40 views

Similarity between the human genome and archea genome in deep sea hydrothermal vents?

I'm trying to find some reference that shows what percentage of the human genome is similar to some organism from the domain Archea that lives near or on deep sea hydrothermal vents. Can someone ...
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1answer
44 views

Bayes theorem for mutations

MEN 2A is a dominant inherited disease caused by a mutation in the RET proto-oncogene. The probability of being sick when you have the mutation of the RET proto-oncogene varies with age and is assumed ...
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1answer
34 views

Mutations/deletions with CRISPR

I need to stop some protein from being active and searching for some universal way to do so. In mammalians. With CRISPR it is possible to knock-out the entire gene. But it's a little complicate ...
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1answer
31 views

Synteny, genetics?

Could anyone explain the concept of Synteny relating to genetics? A picture would help. I tried read the wikipedia source along with another PDF ...
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23 views

Is Mental Disorder X or Y related disease? [on hold]

There are many diseases which are basically linked with the type of chromosome, some are only X linked and some are Y. Just like Color Blindness which is just a X linked disorder. So using that what ...
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1answer
74 views

Does the DNA of a tadpole change after it becomes a frog?

Does the DNA of a tadpole change after it becomes a frog? In other words what changes take place as a tadpole becomes a frog, and does this metamorphosis affect the DNA in any way? I would appreciate ...
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19 views

How is the “fine mapping of pelvic regulatory region” done in this paper?

Could anyone please explain to be in very basic terms how Fig 2, and the associated text(located above the figure) is done? The jargon is too much for me to understand and I really need a simplified, ...
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22 views

Problem involving selfing (inbreeding it with itself) a plant to generate purebred lines

I am working on a past exam problem where the first bit is as follows A plant is repeatably selfed to generate inbred lines. Let $\mathbb{P}(He|He)$ denote the probability that a heterozygous ...
2
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1answer
26 views

What does it mean: carrying the stably integrated gene

Reading this study http://www.nature.com/cr/journal/v23/n10/full/cr2013122a.html They writing Multiple exogenous and endogenous genes can be simultaneously activated by CRISPR-on We tested ...
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1answer
30 views

What is genodiversity good for?

I saw some documents which were trying to say that they can prove via sweat smell selected by women that humans are developed to find a partner with similar genes. At the first glance, I refused it as ...
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1answer
22 views

Quantitative Trait Locus process?

I do not seem to understand the concept of Quantitative Trait Loci(QTL's), can anyone explain it to me in detail? Reading the wikipedia article helped somewhat, but I do not understand it well. What ...
4
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1answer
19 views

In human females one X chromosome is inactivated forming Barr Body. Then How exactly Haemophilia is dominant? check description for details

Suppose a female has one X chromosome normal and one chromosome with Haemophilic gene. Now suppose if the X chromosome which is normal is inactivated will the female show haemophilia?
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36 views

Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
5
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1answer
38 views

what is linkage disequilibrium supposed to measure?

During reading about genetics I came across with the term of linkage disequilibrium, and I do not really understand what it supposed to mean. What is linkage disequilibrium? My current understanding ...
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1answer
29 views

Help reading gene markers

I'm sorry if "gene markers" is not the correct word. An edit could be appreciated but I don't study in an English speaking country unfortunately. Question overview: In a family, there is a genetic, ...
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2answers
31 views

Help reading chromatogram

A genetic variation is found in this chromatogram: It says that the "reference sequence" is the top line and that I can use the general genetic code to find the reading frame. I can see that there ...
2
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1answer
36 views

“bead” on a string theory of genetics, source?

Thomas Hunt Morgan was a pioneer in genetics and proposed the now false model of genes being "beads" on a string. These beads being indivisible and responsible for a single phenotype, if I understand ...
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2answers
385 views

Did cats evolve from monkeys ? or vice versa?

Did cats evolve from monkeys ? or vice versa ? How similar are the genes of cats and monkeys ? What is the proof that they are related or that they are not related ? Most monkeys climb in trees and ...
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1answer
17 views

Do sodium channels keep renewing themselves with new subunits made by genes?

genes make alpha beta gamma subunits (proteins) to be used in making sodium channels... If I understand correctly? And so, since the genes keep making those subunits, does that mean new sodium ...
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1answer
59 views

Is it possible to knock out a gene in adults?

gene knockout is mainly used in creating newborn animals... right? Well can you do it to already-adult animals or humans so that they themselves would experience change in their body and not just ...
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What is the most reliable tumour suppressing gene for NSCLC?

I was looking at some tumour suppressing genes that can be helpful in diagnosing lung cancer (particularly NSCLC - Non-small-cell lung carcinoma) at an early stage. I came across a few such as p53, ...
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2answers
70 views

Non Coding DNA and its effect on evolution

I had a discussion with a friend of mine; from his understanding, bacteria and other small organisms have higher amounts of "coding" DNA and, as such, are able to evolve much faster than organisms ...
2
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1answer
23 views

How do I make conclusions from the autoradiograph of a Southern blot?

Here's another question taken from "Concepts of Genetics," Klug et al (10ed), revolving around a paternity test. PCR and a Southern blot were carried out in order to determine whether 3 chimpanzees ...
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2answers
53 views

GWAS: why is replication in another cohort so crucial?

Almost all the landmark GWAS (Genome-Wide Association Studies) reviews agree that, for a GWAS finding to be valid, it needs to be replicated in an independent cohort. What exactly is the rationale ...
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21 views

Genetic Relationship Matrix

The classical definition of the Genetic Matrix G = ZZ'/2p(1-p) where Z = M - P where P = 2(p-0.5) I don't have a background in biology but understand Maths and ...
3
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1answer
24 views

Forensic genetics- why is mtDNA comparison sometimes better than nDNA comparison?

Why is (in forensic genetics) in some cases more appropriate comparison of nuclear DNA but in some other cases comparison of mitochondrial DNA? Is it because geneticists are sometimes unable to find ...
2
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1answer
19 views

Term for a leaf in a family tree

Imagine a family pedigree. Mathematically it is a graph, which consists of nodes and edges. Nodes being family members, and edges - their relationships. In a clinical setting, what is the proper ...
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1answer
28 views

What governs the distribution of blood vessels?

Whenever someone is sick, doctor places 2 fingers on wrist & observes the heart-beat-rate by feeling pulses of a certain artery. To me it seems the distribution of blood vessels are pretty ...
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31 views

How can the phenotypic effects of a tumor suppressor mutation be silenced?

I've been reading a little about the "two-hit" hypothesis for tumor suppressor genes here, which mentions that some genes exhibiting haploinsufficiency are exceptions to the hypothesis. I've read ...
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1answer
27 views

How to tell if a given gene is a tumor suppressor or oncogene?

This is a problem taken from "Concepts of Genetics", Klug et al, 10e. I'm given the following table about the mutations in the BRCA1 gene: $$\begin{array}{c|c|c|c|c} ...
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1answer
33 views

DIY storing family DNAs' samples for future uses (eg medical)

I have a question I could not get an understandable reply from Google and I am no expert in the matter, so my plead to you is if you could give me practical and relatively easy to follow advice. With ...
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1answer
562 views

Why didn't a concept like “pointers” in Computer Science evolve in the genome?

I see that the genome contains large regions of repeating sequences called interspersed or dispersed elements. The long dispersed elements (LINES) such as LINE-1, can reach up to 6-8 kb in length. ...
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40 views

Where to find gene manipulation video (or photos)

I hope Im not asking a dumb question! Where can i find video of gene manipulation in action under microscope? Like extracting a gene from a cell, fixing gene mutations, putting the gene in a vector, ...
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53 views

Swapping genes?

So, gene therapy is to take out a gene, correct its mutation, and put the corrected one back into the organism, right? Is it also possible to take out a gene from an organism and put in a totally ...
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30 views

Do The Traces Genetic Diseases Remain in families?

I know that there are certain diseases that are predominant on genes. But, is there any sort of surety that if parents are suffering from a disorder then their offspring has to suffer from the same. ...
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1answer
31 views

Genetic Imprinting and Cell differentiaion

It does not seem possible that these two processes can coexist: 1) Genetic imprinting is the phenomenon where genes are expressed differently depending on the parent of origin: 1a. Methylated ...
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1answer
58 views

Are genotypes with the same two alleles equivalent even if the alleles come from different parents?

I am looking at the following question If $m$ alleles may occur at a given locus, how many distinct diploid genotypes are possible at that locus? The obvious answer is that there their is $m$ ...
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1answer
53 views

Hardy-Weinberg Color-blind

In a city, 4% of male population have color blindness. How many of the female are (a) color blind carrier, (b) color blind? Suppose the city holds Hardy Weinberg equilibrium. My progress: 4% of male ...
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1answer
50 views

Markers for human genetic mapping

For human genetic mapping several different types of markers are used: RFLPs (Restriction Fragment Length Polymorphisms) VNTRs (Variable Number of Tandem Repeats) such as mini- and microsatellites ...
2
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1answer
48 views

Horizontal Gene Transfer

I understand the different ways bacteria can undergo horizontal gene transfer (transformation, transduction (phages), conjugation (plasmids)). Is there an experimental method to tell how a specific ...
5
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1answer
145 views

Where do amino acids get attached to tRNA and where is it synthesized?

Some very basic parts of transcription/translation seem to be left out in various literature. I can't find the answer to this anywhere: How exactly is tRNA synthesized? I realize that mRNA is ...
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Solid mouse (C57BL/6) WT primers

I am trying to get a good pair (or better yet, library of pairs) of primers that give me one band in WT mice (C57BL/6). Do you know where I could find such a thing? Alternatively, I thought of just ...
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1answer
119 views

Circadian Clock During a Flight

I am interested to know how does our Circadian Clock respond (and its resultant changes if any) when we are traveling across Time Zones? UPDATE 24th April I am reopening this question as the ...
4
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1answer
25 views

Epistasis Across Chromosomes and Individuals 'Homozygous for Interactions'

Apologies for any failures in nomenclature. I'm a mathematician who is making a foray into genetics for a masters thesis. Specifically, I'm generating artificial diploid genetic sequence data and ...
5
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1answer
116 views

Are there any mutagens that can undo the mutations they cause?

I was reading a section from my textbook about tautomeric shifts, and it seems to suggest that there are some mutagens that can be directly responsible for the phenomenon. The section is mainly ...
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1answer
80 views

Understanding recombination scoring in family pedigrees

I am having some problems understanding recombination, and I am not sure what element I am missing here. This figure is an example from my text book. The pedigree belongs to a family with an autosomal ...
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Are there mechanisms that limit the amounts of time conjugation and F-plasmid transfer can happen? If yes, what are they?

Not all bacteria have acquired F-plasmids through conjugation. Some of the mechanisms for this are unsuccesful conjugation events (mechanical disruption), no transfer due to integration in bacterial ...