Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Current state of Gene Therapy

I am interested in learning about attempts to treat adult individuals suffering from a genetic disease in which the underlying changes in the DNA of the gene are understood. (i) Are there approaches ...
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What are silent carrier traits?

I couldn't find a definition but I have come to know the following from google search: People who are carriers of a thalassemia gene show no thalassemia symptoms and might not know they're ...
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What are sex linked traits?

Which of the two definitions of sex-linked trait is correct? Traits controlled by genes present on the non-homologous region of sex chromosomes are called ...
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Links between Genetics and Personality Types

This topic was visited briefly in the thread, Genetic Effects on Personality, but I was surprised not to find more on it. (Is there a taboo I don't know about? What's the ethical stance on this ...
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Mutating a protein without mutating the gene?

Is it possible to mutate a region of a protein (says about 300 amino acids long) without actually mutating the gene? One possible way that I can think of is to use RNAi and specifically block that ...
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Lyonization and Turner's syndrome

If lyonization is basically inactivation on X chromosome, and Turner's syndrome patients have only one existing X chromosome, what is the difference between healthy women with inactivated X chromosome ...
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556 views

3 flaws of genes from the perspective of a programmer [on hold]

Having a double helix structure seems like a waste of space. In programming you would have a single array and just before mitosis you would double the single helix. Having an exact copy of a ...
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37 views

Can the DNA of 2 women create a child? Chimera [on hold]

Imagine a woman and a man creating a child. The man is in fact a chimera whose unborn twin was a female. Is it possible that some of the spermatozoids of the man contain DNA of only the unborn female ...
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29 views

What is gene density?

As per wikipedia definition, gene density is defined as: "In genetics, the gene density of an organism's genome is the ratio of the number of genes per number of base pairs, usually written in ...
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What are Codominant vs Dominant Genetic Markers?

When talking about types of genetic markers, the adjective "dominant" and "codominant" are often used. I don't fully understand their definitions and found contradicting definitions. Foll and ...
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Statistical genetics: Allele frequencies that follow a Dirichlet distribution

From Foll and Gagiotti (2008) (software BayeScan). They consider a model where several subpopulation are derived from a unique ancestral population. We consider a set of $I$ loci and let $K_i$ be ...
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Mendel Genetics: Homework question

I'm looking at a question right now about Mendel genetics..... Q) When Mendel crossed a large number of tall pea plants with short pea plants, all F1 plants were tall. The F2 generation was created ...
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When was the first exception to Mendelian genetics discovered?

In addition to the the question in the title I'd like to know , how scientists reacted to the exceptions?
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Given the number of individuals who have a recessive disorder, how can one calculate the probability that the disorder was inherited? [on hold]

Just to be clear, this is not homework. Suppose a biological family has five children, two of whom have a certain recessive genetic disorder that is not sex-linked. The parents themselves do not have ...
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Do trees have genes for stopping the grow?

Do trees have genetically encoded to stop growing at some height, to keep dividing the cells only to a certain amount, or to pump nutritions only till it's advantageous because they've already ...
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1answer
64 views

Standard notation for dominant and recessive allele

I'm reading through some science that could come up in my GRE equivalency. I've never been much of a biologist, more of a chemist/geologist....though it does interest me massively! I'm just seeing ...
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Is there selection against long proteins and long genes?

Background thought Titin and TTN Titin is the largest protein in the human genome with 33423 amino acids. Titin is coded by the gene TTN that must be at least $3 \cdot 33423 \approx 100kb$ long. ...
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autosomal recessive population numbers

This question is background research for a science fiction / fantasy novel, my knowledge of genetic is very basic. It seems obvious to me that for genetic disorders that are autosomal recessive, if ...
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How does epigenetics affect the birth conditions via alcohol?

Recent study has shown that epigenetics can play role in male-caused infertility and it cites for example studies which showed an enhancing of silent genes when drinking alcohol. Since the study ...
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Does the Anthony Walsh book “Is Race a Socially Dangerous Idea” have biological merit?

Preface: I'm not a biologist asking this question, but I do find this curious. I was reading Science Wars by Anthony Walsh, and in a chapter titled "Is Race a Socially Dangerous Idea" he outlined the ...
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Genetics - Ancestry DNA relationships

If my uncle and I both got our DNA tested and compared ancestry results, should we have 50% or 25% similarity? I get normally it would be 25% but since the mitochondrial DNA and Y chromosome are ...
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What tell a plant to have one/a lot of flower(s)? [closed]

some plants just have one flower and some have more. This is the question. please simply tell me how? which genes or pathways control this in various plants?
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How do chromosome pairs get “paired up” for protein synthesis?

If my understanding is correct, during interphase a normal human cell will have 46 chromosomes scattered about in the cell nucleus. These chromosomes can be thought of as pairs: there are two copies ...
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Why do mutations in Drosophila dsx (double sex) affect both males and females?

Reason: Loss-of-function mutation of dsx gene in female embryo leads to production of a nonfunctional protein that fails to repress male specific gene expression. So somatic characters of both the ...
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Mendelian genetics - How can we infer the number of genes in play in this scenario?

So this is a practice question I got from school but I kinda lost here. So the question is: In Drosophila , four new recessive mutations have been found all of which produce purple eye ...
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Why would worker bias sex-ratio toward workers?

This question prompts for explanation on a topic, an interpretation of this topic is given. A simplified question statement is also given at the end for those who do not wish to read. Topic In the ...
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How do harsh conditions cause an increase in the male birth ratio?

I've heard that in harsh conditions more human baby boys are born than girls because a bigger ratio of them will die before reproductive age. But in which aspects of the random gene combination while ...
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Recessive is Dominant to Dominant?

If a gene has for instance three alleles, p, q, and r, then could p be dominant to q, q be dominant to r, but r be dominant to p? Can a gene that is recessive to one allele not be dominant to another ...
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How does epigenetics know to mutate which gene in order to survive? [closed]

It seems that during reproduction particular genes are targeted for modification (mutation, deletion, insertion, etc.) given environmental inputs of either or both of the parents. If a creature was ...
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Is there any clear relationship between physical characteristics and patterns in the genome?

Given that for example humans have five fingers on each hand, is there a region in the genome with a sequence of five similar subregions, one for each finger? Is the region on the genome that encodes ...
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Difference between null and recessive allele?

I get that in a single gene locus, an individual can have RR, Rr, or rr as the two alleles ...
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Is it possible to remove one strand of double stranded DNA in vivo?

Assume we do have a double stranded DNA sequence in human cells, say ...ATCGATATCGATATTGCAGAGCATAGCTATAA... ...TAGCTATAGCTATAAGCTCTCGTATCGATATT... Now I want to ...
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Why must DNA be packed into chromosomes during mitotic phase?

Why does DNA have to be packed into chromosomes? Why can't DNA just divide itself evenly?
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Does Cas9 require a nuclear localization signal (NLS) for it to work in a Eukaryote?

I'm trying to establish if it's required to add a NLS to Cas9 when expressed (or transfected) in a Eukaryotic cell. Several papers report using a viral NLS, but is it absolutely necessary? Could ...
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Relationship between genetic diversity within and between species

Here is a quote from Wagner (2008) A second line of evidence [against neutralism] comes from the relationship between the mean number of polymorphic differences between alleles within a species, ...
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Has anyone done a GCTA of leg length? [closed]

There is extensive genomic research on height, but nobody seems to have done a gcta of leg length.
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Dihybrid Cross Help Please

lobe eyes female x crossveinless wing male F1 Progeny: Female lobe eyes: 5023 Male Lobe eyes: 4931 F2 progeny: Female wild: 1241 Male wild:630 Female lobe eyes:3803 Male lobe eyes:1892 ...
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Cell division - meiosis

Really confused. How many chromosomes pairs do humans have in their sex cells? How many single chromosomes do humans have in their sex cells?
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About Hermaphrodite Mitochondrial Inheritance

From the textbook I've learnt that in general mitochondria are inherited maternally. However if the cross is between hermaphrodites (e.g. in C.elegans), where, in most cases, then should the ...
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Is there a term for when a detrimental gene can be positively selected for because of linkage to a very fit gene?

Let's say that some piece of DNA would be subject to extreme negative selection if it were independently inherited, but it is very closely linked to an extraordinarily fit gene, and so the complex it ...
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Are there genes in sex chromosomes that determine facial features?

My friends and I were bored enough to try out this activity. Picture a teenage boy in your mind. From this picture, remove any accessories (glasses, piercings, etc.), moustache or beard, then ...
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Assuming if height was fully determined genetically, what would be the concordance between monozygotic pairs?

I fully understand the differences between monozygotic and dyzogtic twin pairings, but I wondered how I could put into words the reasons why the concordance would be very high. Derived from same ...
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Genetic mutations and new alleles

Amongst silent, nonsense and missense genetic mutations, is the latter the only one that leads to the creation of new alleles? If we define alleles as a specific form of a gene, and a gene as a ...
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What is a “homologous pair” of chromosomes in cross joining or cross over?

I never understand if the chromatids attached at the centromere is a homologous pair, or the male and female chromosomes?
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Why would lethal genes evolve?

I've been reading through 'The Selfish Gene' by Dawkins. At a few places in the book he states that incest is damaging because it would give a very high chance of lethal recessive genes becoming ...
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How to search for all human diseases associated with a inversion on chromosome 22?

Is there any way to search for all diseases that associated with inversions on chr22? I found some online research databases like OMIM and disgenet but I don't know the correct nomenclature on how to ...
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DNA. mRNA, tRNA [closed]

Can someone explain to me how transcription and translation works, especially the part about codes. And does amino acids has code or is it the tRNA?
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What's the exact meaning of and how to derive the coefficient of the path from sire to offspring?

According to Wright's Coefficients of Inbreeding and Relationship, the coefficient of the path from sire to offspring is given as $p_{o \cdot s}=\frac{1}{2}\frac{\sqrt{1+F_s}}{\sqrt{1+F_o}}$ But ...
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2answers
55 views

CRISPR/Cas for editing the human genome [closed]

I know, that the CRISP/Cas approach for "cutting" the human genome is not completely suitable if we can't say not suitable at all. Because we have many repeats and this approach can bring to our ...
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Deducing amino acid sequence from a DNA sequence

The suggested answer to the question is the following: "M L S C D K S D Stop". I do not understand how they get that result. The question is as follows: An RNA polymerase transcribes the following ...