Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Is it theoretically possible to be immortal? [on hold]

I have little idea about gene sequence reading and missing of a particular code in every reading. Is that main key of aging? I mean is telomere partly responsible for this? How can we stop aging?
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Specific genetic code sequence [on hold]

Wikipedia gives the following example of genetic code (this one from mRNA): AUG ACG GAG CUU CGG AGC UAG This sequence appears to be part of a much longer ...
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Can DNA test of my grandparent's brother reveal my heritage from that branch of the family?

I'm thinking about doing that DNA test on all my grandparents to know where their genes come from. They are getting very old and I don't want to let the opportunity pass to gather more knowledge about ...
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67 views

The dominance variance on a single locus

I was reading the book "Genetics and Analysis of Quantitative Traits", by Lynch and Walsh. I how the covariance between two individuals with IBD $\Theta$ gets divided into just the additive variance ...
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32 views

Evolution of Wheat

In the evolution of wheat, there are two instances of chromosomal doubling, when Emmer wheat Triticum turgidum was formed from Einkorn wheat, and when Triticum aestivum was formed from Emmer wheat. ...
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Horizontal gene transfer from humans

It is known that some viruses embed themselves in the human genome. Is there a mechanism by which human genes can be transferred to other animals or plants by means of viruses shuttling them from ...
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22 views

Dominant and recessive epistasis [closed]

Can anyone clarify my confusion about that the epistasis seen in "Labradors , an example of recessive or dominant epistasis? ? I am not getting definite results . It's dominant somewhere and ...
2
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1answer
28 views

Terminology for inefficacy of selection on recessive alleles

I am wondering is there some proper terminology which is used to say that deleterious recessive alleles might be able to hide, reducing the the efficacy of selection, in diploid organisms/chromosomes. ...
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49 views

Stable and strong promoter?

I need a mammalian promoter that will maintain stable expression through differentiation. I was originally planning to employ UbC for this specific project, however new information from a different ...
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1answer
29 views

Cleavage of RNA by restriction enzymes?

Six restriction enzymes discussed in this paper have the ability to detect and cut RNA strands with that enzyme's recognition sequence. As you know, restriction enzymes come from a system carried by ...
2
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1answer
33 views

Mitochondrial D-Loop

I know that the D-loop is a DNA complex in which the strands of double helix DNA molecule are separated for a stretch and held apart by a third strand of DNA. Usually, this third strand has a base ...
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13 views

Linkage Repulsion

"Segregation distorters such as meiotic drivers, involve two loci—a killer (drive) locus and a sensitivity (target) locus—being in strong linkage repulsion to ensure that the drive and ...
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31 views

Genetic notations

Genetic testing revealed these two mutations (hypothetically): IVS11+6G>A and IVS11-4G>A Could you please explain every part of this notation, especially "+" and "-" signs.
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26 views

What will happen to transcription if histone acetyltransferases are removed from a eukaryotic cell?

If HATs are destroyed in a eukaryotic cell, how will gene expression level be affected? Will all gene expression be affected or just be slowed down and most gene will still be expressed?
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3answers
82 views

How does frame-shift mutation not absolutely ruin the organism?

I'm a bit curious as to how frame-shift mutation works. If you shift one amino acid towards another. How does this not affect the entire chromosome? Wouldn't this mean that the organism would be ...
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1answer
31 views

(Genetics) Is a silencer the same as gene silencing (heterochromatin)?

Is silencer the same as gene silencing? I know that gene silencing refers to those heterochromatin concentrated at the telomeres or centromere. It is also related to methylation. But what about a ...
3
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24 views

Multiplex PCR, shorter amplicon inhibiting longer amplicon?

I want to run multiplex PCRs for my genotyping, with a primer pair targeting my construct and a primer pair targeting some housekeeping gene (sort of a built-in control). I designed the control ...
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1answer
33 views

Identify chromosome location from gene nucleotide or amino acid number

I'm sure this is a basic question, but I couldn't find an answer anywhere. Let's say I'm provided with the location of an amino acid or a nucleotide (for example, which lists the location as the ACADM ...
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1answer
44 views

Similarity between the human genome and archea genome in deep sea hydrothermal vents?

I'm trying to find some reference that shows what percentage of the human genome is similar to some organism from the domain Archea that lives near or on deep sea hydrothermal vents. Can someone ...
3
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1answer
48 views

Bayes theorem for mutations

MEN 2A is a dominant inherited disease caused by a mutation in the RET proto-oncogene. The probability of being sick when you have the mutation of the RET proto-oncogene varies with age and is assumed ...
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52 views

Mutations/deletions with CRISPR

I need to stop some protein from being active and searching for some universal way to do so. In mammalians. With CRISPR it is possible to knock-out the entire gene. But it's a little complicate ...
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1answer
31 views

Synteny, genetics?

Could anyone explain the concept of Synteny relating to genetics? A picture would help. I tried read the wikipedia source along with another PDF ...
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1answer
83 views

Does the DNA of a tadpole change after it becomes a frog?

Does the DNA of a tadpole change after it becomes a frog? In other words what changes take place as a tadpole becomes a frog, and does this metamorphosis affect the DNA in any way? I would appreciate ...
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2answers
19 views

How is the “fine mapping of pelvic regulatory region” done in this paper?

Could anyone please explain to be in very basic terms how Fig 2, and the associated text(located above the figure) is done? The jargon is too much for me to understand and I really need a simplified, ...
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Problem involving selfing (inbreeding it with itself) a plant to generate purebred lines

I am working on a past exam problem where the first bit is as follows A plant is repeatably selfed to generate inbred lines. Let $\mathbb{P}(He|He)$ denote the probability that a heterozygous ...
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1answer
28 views

What does it mean: carrying the stably integrated gene

Reading this study http://www.nature.com/cr/journal/v23/n10/full/cr2013122a.html They writing Multiple exogenous and endogenous genes can be simultaneously activated by CRISPR-on We tested ...
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1answer
32 views

What is genodiversity good for?

I saw some documents which were trying to say that they can prove via sweat smell selected by women that humans are developed to find a partner with similar genes. At the first glance, I refused it as ...
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23 views

Quantitative Trait Locus process?

I do not seem to understand the concept of Quantitative Trait Loci(QTL's), can anyone explain it to me in detail? Reading the wikipedia article helped somewhat, but I do not understand it well. What ...
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21 views

In human females one X chromosome is inactivated forming Barr Body. Then How exactly Haemophilia is dominant? check description for details

Suppose a female has one X chromosome normal and one chromosome with Haemophilic gene. Now suppose if the X chromosome which is normal is inactivated will the female show haemophilia?
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38 views

Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
5
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1answer
39 views

what is linkage disequilibrium supposed to measure?

During reading about genetics I came across with the term of linkage disequilibrium, and I do not really understand what it supposed to mean. What is linkage disequilibrium? My current understanding ...
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1answer
32 views

Help reading gene markers

I'm sorry if "gene markers" is not the correct word. An edit could be appreciated but I don't study in an English speaking country unfortunately. Question overview: In a family, there is a genetic, ...
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2answers
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Help reading chromatogram

A genetic variation is found in this chromatogram: It says that the "reference sequence" is the top line and that I can use the general genetic code to find the reading frame. I can see that there ...
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1answer
39 views

“bead” on a string theory of genetics, source?

Thomas Hunt Morgan was a pioneer in genetics and proposed the now false model of genes being "beads" on a string. These beads being indivisible and responsible for a single phenotype, if I understand ...
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403 views

Did cats evolve from monkeys ? or vice versa?

Did cats evolve from monkeys ? or vice versa ? How similar are the genes of cats and monkeys ? What is the proof that they are related or that they are not related ? Most monkeys climb in trees and ...
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Do sodium channels keep renewing themselves with new subunits made by genes?

genes make alpha beta gamma subunits (proteins) to be used in making sodium channels... If I understand correctly? And so, since the genes keep making those subunits, does that mean new sodium ...
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59 views

Is it possible to knock out a gene in adults?

gene knockout is mainly used in creating newborn animals... right? Well can you do it to already-adult animals or humans so that they themselves would experience change in their body and not just ...
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What is the most reliable tumour suppressing gene for NSCLC?

I was looking at some tumour suppressing genes that can be helpful in diagnosing lung cancer (particularly NSCLC - Non-small-cell lung carcinoma) at an early stage. I came across a few such as p53, ...
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100 views

Non Coding DNA and its effect on evolution

I had a discussion with a friend of mine; from his understanding, bacteria and other small organisms have higher amounts of "coding" DNA and, as such, are able to evolve much faster than organisms ...
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1answer
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How do I make conclusions from the autoradiograph of a Southern blot?

Here's another question taken from "Concepts of Genetics," Klug et al (10ed), revolving around a paternity test. PCR and a Southern blot were carried out in order to determine whether 3 chimpanzees ...
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2answers
60 views

GWAS: why is replication in another cohort so crucial?

Almost all the landmark GWAS (Genome-Wide Association Studies) reviews agree that, for a GWAS finding to be valid, it needs to be replicated in an independent cohort. What exactly is the rationale ...
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Genetic Relationship Matrix

The classical definition of the Genetic Matrix G = ZZ'/2p(1-p) where Z = M - P where P = 2(p-0.5) I don't have a background in biology but understand Maths and ...
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1answer
31 views

Forensic genetics- why is mtDNA comparison sometimes better than nDNA comparison?

Why is (in forensic genetics) in some cases more appropriate comparison of nuclear DNA but in some other cases comparison of mitochondrial DNA? Is it because geneticists are sometimes unable to find ...
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1answer
22 views

Term for a leaf in a family tree

Imagine a family pedigree. Mathematically it is a graph, which consists of nodes and edges. Nodes being family members, and edges - their relationships. In a clinical setting, what is the proper ...
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1answer
29 views

What governs the distribution of blood vessels?

Whenever someone is sick, doctor places 2 fingers on wrist & observes the heart-beat-rate by feeling pulses of a certain artery. To me it seems the distribution of blood vessels are pretty ...
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How can the phenotypic effects of a tumor suppressor mutation be silenced?

I've been reading a little about the "two-hit" hypothesis for tumor suppressor genes here, which mentions that some genes exhibiting haploinsufficiency are exceptions to the hypothesis. I've read ...
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1answer
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How to tell if a given gene is a tumor suppressor or oncogene?

This is a problem taken from "Concepts of Genetics", Klug et al, 10e. I'm given the following table about the mutations in the BRCA1 gene: $$\begin{array}{c|c|c|c|c} ...
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3answers
60 views

DIY storing family DNAs' samples for future uses (eg medical)

I have a question I could not get an understandable reply from Google and I am no expert in the matter, so my plead to you is if you could give me practical and relatively easy to follow advice. With ...
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1answer
564 views

Why didn't a concept like “pointers” in Computer Science evolve in the genome?

I see that the genome contains large regions of repeating sequences called interspersed or dispersed elements. The long dispersed elements (LINES) such as LINE-1, can reach up to 6-8 kb in length. ...
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Where to find gene manipulation video (or photos)

I hope Im not asking a dumb question! Where can i find video of gene manipulation in action under microscope? Like extracting a gene from a cell, fixing gene mutations, putting the gene in a vector, ...