Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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RNAs arising from intergenic regions

Which type of RNA molecule is coded for in intergenic regions? I think it must be a non-coding RNA but I'm unsure which type.
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B cell receptor editing

If a B cell contains two mu chains and two lambda chains and is self reactive can it go back and rearrange its kappa light chains? I'm not sure if it can only try to rearrange its lambda light chains ...
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Does one parent transmit more DNA to the offspring than the other one?

Does one parent transmit more DNA to the offspring than the other one? Or do both parents always transmit the same amount of genetic material to their offspring? In other words, can a baby be ...
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What is 'independent assortment'?

What is the definition of 'independent assortment'. I tried researching this term but came back with two results: alleles assort themselves independently of different alleles the alignment of ...
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Are there 23 pairs of chromosomes present in each cell, or in the entire human body? [on hold]

There are 23 pairs of chromosomes. Are these present in each cell, or are there just 23 pairs present in the entire human body?
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Is there an association between environmental and mutational robustness?

The robustness of a genotype is the ability of this genotype to resist (always produce the same phenotype) to various parameters such as mutations and environment. The ability of a genotype to resist ...
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Looking for a gene in my raw genetic data. What are the possible causes for this?

Obviously, I barely know what I am talking about. But I want to find the "MUC5B promoter polymorphism rs35705950" in my RAW genetic data from 23andMe. (see this ...
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169 views

What percentage of the (additive or not) genetic variance is explained by the $n$ most important loci?

Standard models in population genetics look up at the evolution of few loci which impact fitness. The variance in fitness is determined by the genetic variance and the environmental variance (and the ...
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Why is the DNA codon table “equal” to the RNA codon table

Before anything else please pay attention of the double quotes on the "equal" in the title - I know they are not equal, but you will understand in a bit. If I look at the DNA codon table here or in ...
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Do human cells contain only one copy of the genome?

Does each cell contain only a single copy of its genome? Or are there ever 'extra' copies present. Reason behind question: Wondering whether gene mutations could be corrected by referencing a ...
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During bridge amplification of DNA sequences, why aren't sequences amplified in both orientations?

During bridge amplification, when sequences attached to adapters on the surface form "bridges" and are replicated, it seems like sequences with either end attached to the surface will be created. For ...
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How to identify genes required for biofilm formation

This is just a homework question: Q: Let’s assume that there is an unknown set of E. coli genes that are required for biofilm formation. Describe a genetic experiment you could perform to try to ...
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Why do carnivorous animals have odd numbered fingers while herbivorous animals have even numbered fingers? [closed]

What principle they based on? And is different finger' numbers have different function ?
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Will genetically modified food affect our health?

It's a popular public sentiment that - GM foods like tomatoes (flavr savr) will affect our health.. Is there any logical scientific explanation behind this?
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Nature of plasmids [closed]

What are the plasmids composed of?? Genomic DNA or non-genomic DNA ? I think, the answer should be "genomic DNA"...but am not too sure...
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2answers
37 views

regarding genetic disorders related to protein production

I am not completely familiar with biology, but i had a genetics course in college along with practicals. Forgive me if there is something wrong with my question. Is there a genetic disease which ...
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36 views

What is this bizarre in-growth in this red bell pepper?

I just chanced upon a rather strange red bell pepper (or capsicum?): The green formation is bulbous to touch, just the like the outside of the bellpepper, and it has the same smell as one. I'm no ...
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Book Recommendations: GRE Subject Test In Biochemistry, Cell And Molecular Biology

There are probably a lot of really good answers that may vary significantly in terms of content. I'm looking for a set of books that I can read in preparation for the GRE Subject Test In ...
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Is it possible to genetically modify a plant at home?

Would I be able to genetically modify a plant at home? What equipment will be necessary? I think it might be a fun change from the 'norm' of regular hybridisation, to try some inter-family gene ...
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191 views

Paralogous genes in genome-wide association studies?

Has anybody tested if paralogous genes are over-represented among the genes identified by genome-wide association studies (GWAS)? For example, if a GWAS study finds 200 genes associated to the ...
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Centriole genes Knock-out Experiment in Common experimental animals?

Anyone know of any experiments that have knocked out the genes for producing centrioles in a worm, mouse, fish, fly or whatever animal? Are the genes for centrioles even identified? It has been shown ...
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27 views

Where do I purchase a fly with the collagen tagged?

Where can I purchase a fly with tagged collagen? My senior undergraduate research paper is observing the collagen in larvae with normal diet compared to larvae with an experimental diet. I need ...
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57 views

Do human visual functions degenerate due to genetic factors or by external factors?

Does eyesight primarily deteriorate 'naturally' due to genetics (genomic/epigenomic factors), or due to external factors such as normal wear and tear, or disease? By normal wear and tear I include ...
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340 views

Why was it so hard to decode the corn genome?

My teachers growing up told me it was impossible to decode the maize genome. But yet its been done. Why was decoding the genome so significant, and what made it so difficult?
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Need of X or Y chromosome protein after meiosis

After meiosis each spermatid get either the X chromosome or the Y chromosome. I know that the 4 spermatids formed from 1 spermatogonia are connected by cytoplasm and so the proteins made by X or Y ...
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Which is better against genetic mutations? Asexual or Sexual Reproduction?

In terms of genetics, which type of reproduction is better against adverse mutations? I understand a bit of Muller's Ratchet—in which asexual organisms accumulate a number of deleterious mutations in ...
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Word denoting genetic state

Is there a single word, or brief phrase, that denotes the state of the total genetic machinery (genome + transcriptome + proteome + ...) of a cell or organ or organism at a particular point in time?
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What is meant by “genes involved in the stress response”?

I would like to know about the term stress response. For example "some genes of a species under study is involved in stress response". What does that mean? I got this as a part of my assignment ...
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Mechanisms of Gene*sex / Genotype*sex interactions

I'm looking for suggestions of the mechanistic level at which genotype/gene * sex interactions can occur. These give different phenotypes from the same geneotype dependent on the sex they are ...
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Definitions of robustness and canalization

The concepts of robustness and canalization are fashionable today in the biology literature. However, I am not sure of their definitions and I am not sure either that all authors actually use the same ...
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Results of a complete DNA sequencing - are they 100% reusable?

Is that correct that a complete DNA sequencing (the whole genome) need only to be done once (per person)? After that is done, it the complete genome can be stored and once the new genes (and their ...
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Examples of genes involved in plastic responses

Adaptive plasticity involves sensing the environment and responding adaptively to it. Intuitively, I would think that this process may ask for a more or less complex genetic machinery of regulation of ...
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234 views

Double mutant analysis with null mutants

My professor was talking about double mutant analysis with null mutants, and how double mutant analysis won't work with hypomorphs. I really don't understand the concept of double mutant analysis. ...
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Is there are practical lower limit to gene length in E. coli?

Question is rather self-explanatory. Putting aside other post-transcriptional factors like rate of degradation of transcript, what is the smallest gene ever reported to have successfully been ...
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Heterochromatin production limitations

Currently playing with some ideas for a project and needed some guidance. I am wondering, both in Drosophila melanogaster and in general, is the amount of heterochromatin a cell/nucleus can produce ...
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Why are the genomes of some trees so large?

For example, the current longest known genome belongs to a tree: http://motherboard.vice.com/read/the-largest-genome-ever-sequenced-belongs-to-a-tree I have heard that this could potentially be ...
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How do I calculate the change in allele frequency in a haploid population under selection?

From this book For simplicity, let us consider a haploid organism and assume that the frequencies of alleles $A_1$ and $A_2$ are given by $x$ and $y=1-x$, respectively. We also assume that the ...
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What is the minimum population size that Hardy-Weinberg calculations can be applied to?

I'm trying to find out if a particular allele is in Hardy-Weinberg disequilibrium, but the data is poor. What's the minimum population number that you can use to get any sort of respectable ...
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Hill-Roberston effects and effective population size

From this article, first page, middle of the second column: Even if harmful alleles do not become fixed, they can still reduce the efficacy of selection on neighbouring loci through a process ...
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Do men have a higher genetic variance than women?

I've heard that with the distribution of our genetic code women have less variation on the bell curve than men. Is there any basis for this? It was my understanding that women have more genetic ...
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Why is the strength of genetic drift inversely proportional to the population size?

I saw a concept on the Internet that says "the strength of genetic drift is inversely proportional to the population size". I don't know why they are inversely proportional? Can somebody explain? ...
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How often does bacterial transformation happen?

I have been reading: M. Dröge, A. Pühler, W. Selbitschka, "Horizontal gene transfer among bacteria in terrestrial and aquatic habitats as assessed by microcosm and field studies", Biol. Fertil. ...
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Paper on non-viral vectors for CF gene therapy

I am now planning to write a paper now specficially on liposomes vectors for Cystic fibrosis. I am planning to use papers that talked about early trials in animals with liposomes and early clinical ...
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Physiological function of CFTR gene product? [duplicate]

I just need a clarification. If I am to talk about the physiological function of the CFTR gene product? Then what should I do research and talk about? The only physiological function that I can ...
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Finding appropriate research papers?

I had previously asked some question on cystic fibrosis and I had mentioned that I am a senior in high school writing a paper on gene therapy and CF. I would like to some specific paper on viral ...
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Why 22 amino acids instead of 64?

This question got me thinking about amino acids and the ambiguity in the genetic code. With 4 nucleotides in RNA and 3 per codon, there are 64 codons. However, these 64 codons only code for 22 ...
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Is this a valid definition of independent assortment?

"Allelic combinations separate randomly. I.e. a parent might be Aa and Bb for two traits but that doesn't necessarily mean the gametes will strictly be AB or ab but any of a number of combinations. ...
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What are non-heritable changes to genomes?

I am told that mutations are heritable changes to the genome. So this begs the question - what are non-heritable changes to genome?
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What impacts penetrance of Huntington's disease?

From Principles of Life by H. Craig Heller, David E. Sadava, Mary V. Price: From what I understand, Huntington's disease exhibits varying degrees of penetrance depending on how many times the ...
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1answer
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Ways to measure effectiveness of a gene therapy trial?

I understand that Fluorescence in situ hybridisation can be used to measure the effectiveness of a gene therapy experiment/trial. But what are some other genetics techniques to measure the ...