Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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How to seek for available genetic data relevant to ecology and evolution?

I am asking for advice on how to search for available genetic data that can be used for research in ecology and evolution. I am asking a general question and then for a study case question. I had a ...
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84 views

Where does the term “cos site” come from?

The word cosmid is derived from cos sites of lambda phages. Why are cos sites called cos sites? What does this "cos" refer to?
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Are there examples of abnormal human chromosomes that can cause diseases? [on hold]

I was looking into chromosomes and I found the chromosomal abnormalities. I have a limited understanding but I was wondering if someone could clarify it? I was also wondering what numerical, genetic, ...
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Can a woman possessing 1 mutated allele show attenuated color-vision deficiency?

Women possess two X chromosomes. However, during development, when the embryo has about 32 - 64 cells, one of these chromosomes is randomly inactivated (in each cell) by a lncRNA named Xist. As a ...
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Terminology for inefficacy of selection on recessive alleles

I am wondering is there some proper terminology which is used to say that deleterious recessive alleles might be able to hide, reducing the the efficacy of selection, in diploid organisms/chromosomes. ...
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Help reading gene markers

I'm sorry if "gene markers" is not the correct word. An edit could be appreciated but I don't study in an English speaking country unfortunately. Question overview: In a family, there is a genetic, ...
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Do sodium channels keep renewing themselves with new subunits made by genes?

genes make alpha beta gamma subunits (proteins) to be used in making sodium channels... If I understand correctly? And so, since the genes keep making those subunits, does that mean new sodium ...
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Is it theoretically possible to be immortal? [on hold]

I have little idea about gene sequence reading and missing of a particular code in every reading. Is that main key of aging? I mean is telomere partly responsible for this? How can we stop aging?
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68 views

The dominance variance on a single locus

I was reading the book "Genetics and Analysis of Quantitative Traits", by Lynch and Walsh. I how the covariance between two individuals with IBD $\Theta$ gets divided into just the additive variance ...
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60 views

Specific genetic code sequence [on hold]

Wikipedia gives the following example of genetic code (this one from mRNA): AUG ACG GAG CUU CGG AGC UAG This sequence appears to be part of a much longer ...
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Non Coding DNA and its effect on evolution

I had a discussion with a friend of mine; from his understanding, bacteria and other small organisms have higher amounts of "coding" DNA and, as such, are able to evolve much faster than organisms ...
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44 views

Can DNA test of my grandparent's brother reveal my heritage from that branch of the family?

I'm thinking about doing that DNA test on all my grandparents to know where their genes come from. They are getting very old and I don't want to let the opportunity pass to gather more knowledge about ...
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42 views

Horizontal gene transfer from humans

It is known that some viruses embed themselves in the human genome. Is there a mechanism by which human genes can be transferred to other animals or plants by means of viruses shuttling them from ...
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32 views

Evolution of Wheat

In the evolution of wheat, there are two instances of chromosomal doubling, when Emmer wheat Triticum turgidum was formed from Einkorn wheat, and when Triticum aestivum was formed from Emmer wheat. ...
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Is it possible for a child to grow taller than their tallest parent?

I have heard that off spring can't grow taller than either of their parents but I've also heard that sometimes some gene activation can skip generations. Is it possible for a child to grow taller than ...
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1answer
171 views

Do genes play a role in the athleticism and shape of a person?

I am an Indian with a small thin stature with some deposition of fat around my belly.I was wondering if genes play a role in fat deposition in the body for Indian, Chinese, European or African people. ...
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Dominant and recessive epistasis [closed]

Can anyone clarify my confusion about that the epistasis seen in "Labradors , an example of recessive or dominant epistasis? ? I am not getting definite results . It's dominant somewhere and ...
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1answer
49 views

Stable and strong promoter?

I need a mammalian promoter that will maintain stable expression through differentiation. I was originally planning to employ UbC for this specific project, however new information from a different ...
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7k views

Why 22 amino acids instead of 64?

This question got me thinking about amino acids and the ambiguity in the genetic code. With 4 nucleotides in RNA and 3 per codon, there are 64 codons. However, these 64 codons only code for 22 ...
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1answer
29 views

Cleavage of RNA by restriction enzymes?

Six restriction enzymes discussed in this paper have the ability to detect and cut RNA strands with that enzyme's recognition sequence. As you know, restriction enzymes come from a system carried by ...
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60 views

DIY storing family DNAs' samples for future uses (eg medical)

I have a question I could not get an understandable reply from Google and I am no expert in the matter, so my plead to you is if you could give me practical and relatively easy to follow advice. With ...
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1answer
34 views

Mitochondrial D-Loop

I know that the D-loop is a DNA complex in which the strands of double helix DNA molecule are separated for a stretch and held apart by a third strand of DNA. Usually, this third strand has a base ...
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1answer
40 views

In insects, does the Alanine repeat occur on the homeodomain sequence of the abdomen or does it occur on a different sequence?

By "Alanine repeat", I am referring to the suppression of the formation of extra insect legs due to Ubx gene suppression through Distal-less repression.
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Genetic Imprinting and Cell differentiation

It does not seem possible that these two processes can coexist: 1) Genetic imprinting is the phenomenon where genes are expressed differently depending on the parent of origin: 1a. Methylated ...
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What is the function of the RNA primer in DNA replication?

During DNA replication, RNA primase puts an RNA primer in the lagging strand. What is the function of this RNA primer? Why can't the enzymes put DNA fragments directly?
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Linkage Repulsion

"Segregation distorters such as meiotic drivers, involve two loci—a killer (drive) locus and a sensitivity (target) locus—being in strong linkage repulsion to ensure that the drive and ...
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52 views

Mutations/deletions with CRISPR

I need to stop some protein from being active and searching for some universal way to do so. In mammalians. With CRISPR it is possible to knock-out the entire gene. But it's a little complicate ...
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31 views

Genetic notations

Genetic testing revealed these two mutations (hypothetically): IVS11+6G>A and IVS11-4G>A Could you please explain every part of this notation, especially "+" and "-" signs.
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82 views

How does frame-shift mutation not absolutely ruin the organism?

I'm a bit curious as to how frame-shift mutation works. If you shift one amino acid towards another. How does this not affect the entire chromosome? Wouldn't this mean that the organism would be ...
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What will happen to transcription if histone acetyltransferases are removed from a eukaryotic cell?

If HATs are destroyed in a eukaryotic cell, how will gene expression level be affected? Will all gene expression be affected or just be slowed down and most gene will still be expressed?
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31 views

(Genetics) Is a silencer the same as gene silencing (heterochromatin)?

Is silencer the same as gene silencing? I know that gene silencing refers to those heterochromatin concentrated at the telomeres or centromere. It is also related to methylation. But what about a ...
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Gametes of two different species

I always wondered why gametes from two different species dont fuse together to form an offspring. eg a donkey (sperm) and a female dog (egg) I know this is not possible but I'm just curious.
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Multiplex PCR, shorter amplicon inhibiting longer amplicon?

I want to run multiplex PCRs for my genotyping, with a primer pair targeting my construct and a primer pair targeting some housekeeping gene (sort of a built-in control). I designed the control ...
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1answer
44 views

Similarity between the human genome and archea genome in deep sea hydrothermal vents?

I'm trying to find some reference that shows what percentage of the human genome is similar to some organism from the domain Archea that lives near or on deep sea hydrothermal vents. Can someone ...
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33 views

Identify chromosome location from gene nucleotide or amino acid number

I'm sure this is a basic question, but I couldn't find an answer anywhere. Let's say I'm provided with the location of an amino acid or a nucleotide (for example, which lists the location as the ACADM ...
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Bayes theorem for mutations

MEN 2A is a dominant inherited disease caused by a mutation in the RET proto-oncogene. The probability of being sick when you have the mutation of the RET proto-oncogene varies with age and is assumed ...
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31 views

Synteny, genetics?

Could anyone explain the concept of Synteny relating to genetics? A picture would help. I tried read the wikipedia source along with another PDF ...
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269 views

Crossing white eyed Drosophila with sepia eye

So, I'm doing some drosophila experiments with my high schoolers and I had really poor production of wild type individuals for doing the experiment resulting in not enough to cross with everyone... I ...
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1answer
84 views

Does the DNA of a tadpole change after it becomes a frog?

Does the DNA of a tadpole change after it becomes a frog? In other words what changes take place as a tadpole becomes a frog, and does this metamorphosis affect the DNA in any way? I would appreciate ...
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What determines if a gene is dominant or recessive?

Going back to my high school days we were taught about dominant and recessive genes. We were taught how to calculate the geneotype and pheneotype of potential offspring using a small table (forgotten ...
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How is the “fine mapping of pelvic regulatory region” done in this paper?

Could anyone please explain to be in very basic terms how Fig 2, and the associated text(located above the figure) is done? The jargon is too much for me to understand and I really need a simplified, ...
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Problem involving selfing (inbreeding it with itself) a plant to generate purebred lines

I am working on a past exam problem where the first bit is as follows A plant is repeatably selfed to generate inbred lines. Let $\mathbb{P}(He|He)$ denote the probability that a heterozygous ...
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1answer
28 views

What does it mean: carrying the stably integrated gene

Reading this study http://www.nature.com/cr/journal/v23/n10/full/cr2013122a.html They writing Multiple exogenous and endogenous genes can be simultaneously activated by CRISPR-on We tested ...
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Father with mutated mtDNA- why isn't his offspring at risk?

Mothers transmit their mitochondria (and therefore mtDNA) to their offspring and fathers don't. Lets assume that father had a mutation of the gene that encodes mtDNA, would then be his offspring at ...
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1answer
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What is genodiversity good for?

I saw some documents which were trying to say that they can prove via sweat smell selected by women that humans are developed to find a partner with similar genes. At the first glance, I refused it as ...
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1answer
23 views

Quantitative Trait Locus process?

I do not seem to understand the concept of Quantitative Trait Loci(QTL's), can anyone explain it to me in detail? Reading the wikipedia article helped somewhat, but I do not understand it well. What ...
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481 views

TCGA data, and bioinformatics design questions for SNP/ mirna analysis

It's my first time posting to this forum but was looking for some help on the data aspects of this project. My tools of choice would be in python/R . Goal: I'm looking to create a disease specific ...
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100 views

Best way to automatically link Gene Entrez ID with Gene Symbol in TCGA

I am trying to figure out how to link Gene Entrez ID with Gene Symbol, for TCGA dataset. So far, I have found this ftp directory with Gene info updated daily. But, for Entrez ID 728661, I have found ...
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254 views

Mapping a mutation to known SNP, 3' UTR, miR

I've parsed out a very large TCGA cancer ssm (single mutation file) file to give me the essential information. The ssm is in the following format: ...