Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Do “transcription factor binding site” and “operator” mean the same thing?

Can the terms "transcription factor binding site" and "operator" be used interchangeably in all contexts when referring to a DNA sequence, e.g. regardless of a cell type, whether or not the binding ...
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156 views

What type of mutation causes Progeria?

I'm doing my High School biology final on Progeria, and am wondering what type of mutation causes this disease. I know that the LMNA gene codes for the "prelamin A" protein, and that protein contains ...
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50 views

Genetics - Is this hybridization possible?

Suppose you hybridize two plants - One has a red flower and a long stalk, the other has a pink flower and a short stalk. This resulted in these 4 type of plants, with ratio 1:1:1:1 Long stalk red ...
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180 views

Eusociality and Natural selection?

Eusociality, particularly focusing on the presence of certain altruistic sterile organisms within the social set-up creates questions as to why would the process of natural selection have favoured the ...
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Which X-Y chromosomes have the developmental genes for mammals?

I know that for a given mammal, half the chromosomes come from father and half from mother. This is typically denoted as x-y. I've recently read about "toolkit" genes that control how a cell develops ...
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26 views

Basic Gene/Chromosome/Genome/Protein question.. which comes first? [closed]

How are they ordered? Genes make up Chromosome, and Chromosomes make up a Genome... So, where does Protein come into play? What do you call Genes that are spliced together to form something new? ...
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434 views

Book Recommendations: GRE Subject Test In Biochemistry, Cell And Molecular Biology

There are probably a lot of really good answers that may vary significantly in terms of content. I'm looking for a set of books that I can read in preparation for the GRE Subject Test In ...
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28 views

Where do I purchase a fly with the collagen tagged?

Where can I purchase a fly with tagged collagen? My senior undergraduate research paper is observing the collagen in larvae with normal diet compared to larvae with an experimental diet. I need ...
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60 views

Gene Therapy for Cystic Fibrosis

I have another question regarding cystic fibrosis. I understand that gene therapy is currently being talked about in the cure for cystic fibrosis. I know that Eric Alton at imperial college London is ...
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112 views

What is the difference between a fixed substitution and a single nucleotide polymorphism (SNP)?

I recently read a report that stated "We found 430 fixed substitutions […], with an additional 34 single nucleotide polymorphisms (SNPs) fixed within individual patients." What is the difference ...
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what is the modern, molecular explanation of independent assortment of alleles?

in case it isn't obvious i'll begin by stating that i'm a layman, trying to understand something about this subject from reading books. the books i've looked at so far give murky and confusing ...
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86 views

Understanding DNA supercoiling

While trying to understand DNA supercoiling, I came across these lines in the book Genetics by Ursula Goodenough : All natural DNA is superhelical. The axis of the duplex itself follows a ...
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205 views

X Linked Hardy Weinberg Equilibrium Problem

In a given population under Hardy Weinberg equilibrium, 40.0% of men have hemophilia. What is the probability that a random man and random woman will have a daughter with hemophilia? I think the ...
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145 views

Suggestions for an experiment? [closed]

I would appreciate suggestions for my year-long AP Biology project. Such a project would consists of a standard experiment, to be done over the period of a year, so it would have >to be fairly ...
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51 views

How are geneticists able to isolate gene functions?

As an example, this Scientific American article describes a known area in the dog genome that metabolizes carbohydrates. How is it that researchers are able to determine specific functions such as ...
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255 views

Would two species of yeast with similar genome sizes have the same number of genes or chromosomes?

Similar organisms generally have similar genome sizes. Given this, would two species of yeast have the same number of genes and chromosomes? Edit: Fixed with thanks to @daniel-standage
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41 views

What is the expected number of children that need to be born for every possible point mutation to occur once? [closed]

I'm reading The Perfect Health Diet, and in it the author says that the probability of a point mutation is (175/3*10^9) per new child. He then goes on to write: In the Paleolithic, with 100000 ...
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40 views

How was the origin of CTVT parasitic cancer determined?

The wikipedia article on CTVT says that the tumor cell has 57-64 chromosome while a normal dog has 78 chromosomes. Similarly while all chromosomes in dogs except the X and Y chromosomes are ...
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33 views

What is Mendelian Segregation and how is it related to the Hardy-Weinberg equilibrium?

I can't find the exact definition of Mendelian segregation. In addition, I am wondering how it is related to the Hardy-Weinberg equilibrium?
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66 views

(how) is it possible to choose the biological sex of a child? [closed]

I recently read of a study that investigated the ethics of child's biological sex choice in humans, and now I want to find out how this can/could be done. Does anyone know of scientific papers or ...
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113 views

How is incomplete dominance different from codominance?

Ok let me start with the definitions of incomplete dominance and codominance. incomplete dominance - The situation in which the phenotype of heterozygotes is intermediate between the phenotypes of ...
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RNAs arising from intergenic regions

Which type of RNA molecule is coded for in intergenic regions? I think it must be a non-coding RNA but I'm unsure which type.
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54 views

What is meant by “genes involved in the stress response”?

I would like to know about the term stress response. For example "some genes of a species under study is involved in stress response". What does that mean? I got this as a part of my assignment ...
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52 views

Definitions of robustness and canalization

The concepts of robustness and canalization are fashionable today in the biology literature. However, I am not sure of their definitions and I am not sure either that all authors actually use the same ...
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66 views

Influence of temperature on protein binding and decay rates

For computer modeling purposes, I am looking for some referenced quantitative measurements of the effect(s) of temperature on the dynamic of biochemical reactions. Question In particular, my ...
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85 views

Is the mutation rate in organisms in general consistent over the genome?

Coming from computer science with an interest in genetic programming (a process emulating evolution) I'm curious about whether the rate of mutation is homogeneous across the whole genome, or if some ...
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Primers on Dystonia

Where can I get a good biochemical overview of dystonia? I will be working in a research lab that focuses on dystonia and I would like to not be clueless.
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72 views

Religion and Genetics

Are there studies that investigate the heritability of believing in supernatural things (or related concepts)? Or stated differently. Are there studies that ...
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Why is the human body hair not uniformly colored?

Most of my body hair is black however my lip hair is light brown/blonde the rest of my beard region is black. Since hair color is genetic what causes this?
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72 views

What does min mean?

I read that "trp operon is located at 27 min on E.coli chromosome." What does "min" mean ?
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Distribution of genotypes after adverse selection

I am doing some research into Mendelian genetics and came across this phrase called adverse selection. I found a few questions but I am unsure of the calculations. ...
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69 views

Genotypic distribution of a population with two characteristics and linkage

I am currently doing some research into distributions and probabilities with Mendellian genetics. I came across this problem that I cannot seem to wrap my head around. Given that the population has ...
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33 views

What are good data on the Human Metabolic Model and where can I get them?

Trying to get a good SBML representation of the Human Metabolic Model for use in Flux Balance Analysis and drug targetting (i.e. gene knockout) simulations. What are good sources for these data? ...
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65 views

Pseudosexual reproduction

Research projects with artificial life generally use creatures that are haploid. The offspring randomly inherit some genes from one parent, and some genes from the other parent. Q1: Are there any ...
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154 views

mouse gene translated to human gene

I have a list of mouse genes, but all our analysis happens for human genes. Is that possible to translate these mouse genes to human genes? and is there any tool that can help me on this? I am ...
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198 views

Is the SRY gene the sole responsible of biological male sex?

It's very well known that the Y chromosome is what determines maleness, but more specifically this seems to happen thanks to the SRY gene located on it. Some individuals have an XX karyotype, but ...
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140 views

Do genes play a role in the athleticism and shape of a person?

I am an Indian with a small thin stature with some deposition of fat around my belly.I was wondering if genes play a role in fat deposition in the body for Indian, Chinese, European or African people. ...
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113 views

explanation of conjugation experiment in bacteria

In this paper (On the expression of a structural gene) I am confused about what is being plotted in Figure 6. The x-axis contains the fraction of radioactive day and y-axis contains the enzyme ...
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131 views

Why is the 4.4 kb band barely visible in this HindIII digest of lambda DNA?

Why is the 4.4 kb band barely visible? Also, what is the mass (ng) of DNA in band X if lane S contains 250 ng of digested lambda phage DNA?
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Why is the function of lacA (encoding thiogalactoside transacetylase) not clearly understood?

It's almost half a century since the lac operon was discovered but isn't it weird that the precise role of transacetylase isn't clearly understood ? Here a wikipedia article with a link to a journal ...
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134 views

Why do I have a lot in common with my mother? [closed]

I have not spoken to my mother in 15 years but recently connected with her and her side of the family. I was primarily raised in a different sub-culture after the age of 4. As it turns out I ...
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167 views

Expression of plasmid genes

Are plasmid genes always expressed? If so, then isn't a bacterium wasting it's resources in expressing genes (like antibiotic resistance) which are not required in "normal" conditions? If not, then ...
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53 views

Method to inject genes into cells

The famous Hershey and Chase Experiment uses phages to inject genes into cells. In the beginning, Professor Yamanaka injected 24 types of genes into cells to figure out which genes turn a cell into ...
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125 views

Which texts are good for beginners to understand evolution on the genetic scope?

Are there good texts to study the evolution, how it works, and how mutations and changes lead to evolution of the organism ? And how does the information increase through the long time using ...
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104 views

Hardy-Weinberg applied to three alleles and stimation of allele frequencies

I have this equation: Corresponds to HW in equilibria with three alleles: $(p+q+r)^2=1$ Expanding the square results: $p^2+2pq+r^2+2pr+q^2+2qr = 1$ I need to separate homozygous and ...
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170 views

Hardy-Weinberg Equilibrium: To compute probability of finding two siblings (random mating)

I've been working a little with M. G. Bulmer's Principles of Statistics (Dover, 1979) and cannot see how to properly compute half of one question. This should be a basic probability computation, but I ...
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88 views

Expression of an ancestral gene

Why would the expression of an ancestral gene and comparing the product to a modern protein give misleading conclusions about heredity? Update: By ancestral gene I mean a gene which was used by an ...
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Why crossing over don't happen in mitosis?

I mean if there would be crossing over in mitosis then there would various nature of somatic cells. May be that's the logic,but what is the mechanism?why there is no crossing over in mitosis? Does ...
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During bridge amplification of DNA sequences, why aren't sequences amplified in both orientations?

During bridge amplification, when sequences attached to adapters on the surface form "bridges" and are replicated, it seems like sequences with either end attached to the surface will be created. For ...
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Centriole genes Knock-out Experiment in Common experimental animals?

Anyone know of any experiments that have knocked out the genes for producing centrioles in a worm, mouse, fish, fly or whatever animal? Are the genes for centrioles even identified? It has been shown ...