Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Book Recommendations: GRE Subject Test In Biochemistry, Cell And Molecular Biology

There are probably a lot of really good answers that may vary significantly in terms of content. I'm looking for a set of books that I can read in preparation for the GRE Subject Test In ...
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Is it possible to genetically modify a plant at home?

Would I be able to genetically modify a plant at home? What equipment will be necessary? I think it might be a fun change from the 'norm' of regular hybridisation, to try some inter-family gene ...
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Paralogous genes in genome-wide association studies?

Has anybody tested if paralogous genes are over-represented among the genes identified by genome-wide association studies (GWAS)? For example, if a GWAS study finds 200 genes associated to the ...
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Centriole genes Knock-out Experiment in Common experimental animals?

Anyone know of any experiments that have knocked out the genes for producing centrioles in a worm, mouse, fish, fly or whatever animal? Are the genes for centrioles even identified? It has been shown ...
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27 views

Where do I purchase a fly with the collagen tagged?

Where can I purchase a fly with tagged collagen? My senior undergraduate research paper is observing the collagen in larvae with normal diet compared to larvae with an experimental diet. I need ...
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63 views

Do human visual functions degenerate due to genetic factors or by external factors?

Does eyesight primarily deteriorate 'naturally' due to genetics (genomic/epigenomic factors), or due to external factors such as normal wear and tear, or disease? By normal wear and tear I include ...
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340 views

Why was it so hard to decode the corn genome?

My teachers growing up told me it was impossible to decode the maize genome. But yet its been done. Why was decoding the genome so significant, and what made it so difficult?
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160 views

Need of X or Y chromosome protein after meiosis

After meiosis each spermatid get either the X chromosome or the Y chromosome. I know that the 4 spermatids formed from 1 spermatogonia are connected by cytoplasm and so the proteins made by X or Y ...
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45 views

Which is better against genetic mutations? Asexual or Sexual Reproduction?

In terms of genetics, which type of reproduction is better against adverse mutations? I understand a bit of Muller's Ratchet—in which asexual organisms accumulate a number of deleterious mutations in ...
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42 views

Word denoting genetic state

Is there a single word, or brief phrase, that denotes the state of the total genetic machinery (genome + transcriptome + proteome + ...) of a cell or organ or organism at a particular point in time?
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Mechanisms of Gene*sex / Genotype*sex interactions

I'm looking for suggestions of the mechanistic level at which genotype/gene * sex interactions can occur. These give different phenotypes from the same geneotype dependent on the sex they are ...
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45 views

Definitions of robustness and canalization

The concepts of robustness and canalization are fashionable today in the biology literature. However, I am not sure of their definitions and I am not sure either that all authors actually use the same ...
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145 views

Results of a complete DNA sequencing - are they 100% reusable?

Is that correct that a complete DNA sequencing (the whole genome) need only to be done once (per person)? After that is done, it the complete genome can be stored and once the new genes (and their ...
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253 views

Double mutant analysis with null mutants

My professor was talking about double mutant analysis with null mutants, and how double mutant analysis won't work with hypomorphs. I really don't understand the concept of double mutant analysis. ...
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52 views

Is there are practical lower limit to gene length in E. coli?

Question is rather self-explanatory. Putting aside other post-transcriptional factors like rate of degradation of transcript, what is the smallest gene ever reported to have successfully been ...
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35 views

Heterochromatin production limitations

Currently playing with some ideas for a project and needed some guidance. I am wondering, both in Drosophila melanogaster and in general, is the amount of heterochromatin a cell/nucleus can produce ...
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1answer
37 views

Why are the genomes of some trees so large?

For example, the current longest known genome belongs to a tree: http://motherboard.vice.com/read/the-largest-genome-ever-sequenced-belongs-to-a-tree I have heard that this could potentially be ...
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554 views

How do I calculate the change in allele frequency in a haploid population under selection?

From this book For simplicity, let us consider a haploid organism and assume that the frequencies of alleles $A_1$ and $A_2$ are given by $x$ and $y=1-x$, respectively. We also assume that the ...
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189 views

What is the minimum population size that Hardy-Weinberg calculations can be applied to?

I'm trying to find out if a particular allele is in Hardy-Weinberg disequilibrium, but the data is poor. What's the minimum population number that you can use to get any sort of respectable ...
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97 views

Hill-Roberston effects and effective population size

From this article, first page, middle of the second column: Even if harmful alleles do not become fixed, they can still reduce the efficacy of selection on neighbouring loci through a process ...
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579 views

Do men have a higher genetic variance than women?

I've heard that with the distribution of our genetic code women have less variation on the bell curve than men. Is there any basis for this? It was my understanding that women have more genetic ...
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319 views

Why is the strength of genetic drift inversely proportional to the population size?

I saw a concept on the Internet that says "the strength of genetic drift is inversely proportional to the population size". I don't know why they are inversely proportional? Can somebody explain? ...
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37 views

How often does bacterial transformation happen?

I have been reading: M. Dröge, A. Pühler, W. Selbitschka, "Horizontal gene transfer among bacteria in terrestrial and aquatic habitats as assessed by microcosm and field studies", Biol. Fertil. ...
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16 views

Physiological function of CFTR gene product? [duplicate]

I just need a clarification. If I am to talk about the physiological function of the CFTR gene product? Then what should I do research and talk about? The only physiological function that I can ...
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Why 22 amino acids instead of 64?

This question got me thinking about amino acids and the ambiguity in the genetic code. With 4 nucleotides in RNA and 3 per codon, there are 64 codons. However, these 64 codons only code for 22 ...
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28 views

Is this a valid definition of independent assortment?

"Allelic combinations separate randomly. I.e. a parent might be Aa and Bb for two traits but that doesn't necessarily mean the gametes will strictly be AB or ab but any of a number of combinations. ...
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75 views

What are non-heritable changes to genomes?

I am told that mutations are heritable changes to the genome. So this begs the question - what are non-heritable changes to genome?
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What impacts penetrance of Huntington's disease?

From Principles of Life by H. Craig Heller, David E. Sadava, Mary V. Price: From what I understand, Huntington's disease exhibits varying degrees of penetrance depending on how many times the ...
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80 views

XXY (Klinefelter's) & Trisomy 21 & X-inactivation

I read that X-inactivation doesn't tend to happen in males, but then when someone is XXY, they are a male because of the Y. However these individuals tend to live. So does that mean that ...
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Functions of the CFTR gene?

I am a senior in high school and I am studying cystic fibrosis. I don't quite get the function of the CFTR gene as this is my first time dealing with this type of heavy scientific info. I had ...
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33 views

Gene Therapy for Cystic Fibrosis

I have another question regarding cystic fibrosis. I understand that gene therapy is currently being talked about in the cure for cystic fibrosis. I know that Eric Alton at imperial college London is ...
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61 views

How exactly can dsRNA be introduced to a cell?

Is it just by viruses or are there other means by which it gets into cells, such as plasmid uptake?
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26 views

If hermaphrodite C. elegans can reproduce with females?

C. elegans can self fertilize, or they can mate with males. But are they able to mate with females? Or is there some kind of morphological barrier that prevents that?
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65 views

Redundancy of the genetic code

One particular codon codes only for one amino acid, but an amino acid can be coded for by several different codons. Now according to the genetic code, the codon UUU ...
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28 views

Explain the mode of inheritance and determine genotypes [closed]

Please help me with the following question. I am really struggle with it. Every time you cross male and female flies with star eyes and dichaete wings, you observe a phenotypic ratio of 4 star, ...
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41 views

Earliest and latest onset of Huntington's Disease(Chorea)?

Huntington's disease can hit at any age, although it tends to hit middleaged people most often. What is the youngest and oldest person that has exhibited Huntington's? Clarification: By oldest I mean ...
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37 views

DNA methylation on the forward vs reverse strand?

I'm wondering if there are meant to be differences in DNA methylation between the forward and the reverse strand of the gene? I'm wondering because in primer design for bisulfite pyrosequencing one ...
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Hardy Weinberg Equilibrium after 5 Generations

1 There is a population not at HWE where red eye = $a^+$ (dominant) and white eyes = $a^-$. if $a^+/a^+ = 0.6$ $a^-/a^+ = 0.1$ $a^-/a^- = 0.3$ what are the frequencies of the $a^+$ and $a^-$ ...
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76 views

Are all functions of a human cell known? [closed]

Please bear with me as I'm intruding into your world from a computer science background. In programming, once you have created a program, you know all functions of that program. Thus, 100% knowledge ...
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What kind of technology is required for plant seed DNA printing? [closed]

I'm a programmer so I have little knowledge in the field of biology. However I have an interest in plants, GMOs and DNA (in terms of programming). So, I want to know what kind of technology is ...
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Artificial Gene Alteration [closed]

Is artificial alteration/"correction" of genes conceivable? I know viruses can manipulate DNA or RNA to replicate itself, but its only temporary, right? If this were possible, how would it be gone ...
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How does non-homologous end joining (NHEJ) work?

I was reading about non-homologous end joining (NHEJ) in my molecular biology of the gene textbook but the explanation provided in the text was rather vague to me, and I was not able to understand it ...
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Can sealed epiphyseal growth plates theoretically be restored via epigenetic or genetic methods?

I know that epiphyseal growth plates seal up once people become young adults and that it is currently impossible to restore them to actively produce new bone growth but, is it theoretically possible ...
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356 views

Is it possible for a child to grow taller than their tallest parent?

I have heard that off spring can't grow taller than either of their parents but I've also heard that sometimes some gene activation can skip generations. Is it possible for a child to grow taller than ...
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1answer
95 views

What is the result of meiosis?

Is the result of meiosis ONLY the sex gametes (male and female) which later meet to form a somatic cell? Sometimes I feel as if my book is hinting towards meiosis is the process where sperm cells meet ...
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Incomplete Dominance and Probability

I have a follow-up question about an in-lecture question (this is not a homework question). As you can see I have already answered the question and the question is closed to further submissions. ...
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Why has grey hair evolved?

A vast majority of humans get at least some grey hair as they age. As far as I know this applies to both genders and all races. Presumably this means that at least some grey haired humans have ...
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1answer
50 views

Why do our epiphyseal plates close up in our late teens or early twenties?

What causes our epiphyseal plates close up in our late teens or early twenties? I realize that one's genetics plays the main role in this. I assume there is a gene that controls the epiphyseal plates ...
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52 views

Chromatids in metaphase?

Please see the following picture: In my book, the author claims that these chromosomes are in metaphase (a metaphase stopped by cholchicin). I don't understand why they don't have two ...
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At what rate do chromosomal rearrangements occur?

How often does chromosomal rearrangements occur? i.e. what is the rate of chromosomal rearrangements? I am interested about these kind of chromosomal rearrangements that are passed on to the ...