Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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ExAC Browser: What does a “dubious variant annotation” actually mean? [closed]

I wonder how a "dubious" variant annotation is exactly defined in ExAC. I couldn't find any further information neither at the variant's page nor in the FAQs. Link to ExAC browser. Link to variant ...
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1answer
47 views

Determination of genes to be modified in epigenetics [closed]

It seems that during reproduction particular genes are targeted for modification (mutation, deletion, insertion, etc.) given environmental inputs of either or both of the parents. If a creature was ...
5
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2answers
121 views

Is it possible to have different genes in different parts of our body?

I want to understand genetic mutation specially in the context of multicellular organisms like humans. I studied biology only till high school and I can’t fully understand wikipedia pages on this ...
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16 views

Why can dogs not have a pink(ish) coat color?

In yellow dogs, there is a mutation in the MC1R gene which leads to a nonfunctional receptor. This leads to the production of pheomelanin which is pink/red (depending on concentration) instead of ...
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4answers
2k views

Book recommendation on population/evolutionary genetics?

I have recently been involved in collaborations that require me to model the population genetics of eukaryotic populations. I fear I may either be "re-inventing the wheel" or making conceptual ...
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13 views

Is there any technique other than restriction enzymes to introduce staggered cuts into DNA?

I'm curious about introducing staggered cuts into DNA, but wonder if there is a way to do this in vivo in E. coli, as I heard introducing restriction enzymes on a plasmid would end up just shredding ...
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17 views

How do you technically perform the Ames test?

Is it necessary to take into account the volume of gm-agar(bottom) in the concentration determination, or is that determined only by the concentration in the top agar? I found several articles that ...
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1answer
27 views

Can restriction sites be used as PCR primers?

I have a DNA fragment that contains the gene of interest sandwiched by restriction enzyme sites. Then, can PCR amplify the entire fragment, recognizing the restriction enzyme sites?
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1answer
51 views

Why People have skin color between fair and dark? [closed]

According to Mendel's laws traits do not show any blending. So according to his laws people only with fair or dark skin should exist. Do the alleles in this case blend? And why?
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1answer
40 views

Why was the study of “Concordance of Monozygotic and Dizygotic twins for traits” designed in this way? [closed]

I am confused by the twin study 'Concordance of Monozygotic and Dizygotic twins for traits.' My questions arose from 3:17-4:17 of the video And this is the related data I have referred I have ...
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21 views

Hybridization of an Indo-Aryan ethnic group and a Tibeto-Burmese ethnic group

The state in which I reside houses these two distinct ethnic groups. Physical Traits of the Indo-Aryan group Height:Medium Eyes:does not posses epicanthic fold Nasal bones:is not flat and broad ...
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2answers
387 views

Why is a heritability coefficient not an index of “how genetic” something is?

On his blog, Eric Turkheimer writes: [T]aken as a number, a unit of analysis, heritability coefficients are funny things to aggregate on such a massive level. What exactly are we supposed to ...
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2answers
57 views

What´s the origin of junk DNA?

Most eukaryotes posses a certain amount of junk DNA in their cell nuclei. What is (are) the origin(s) of this junk DNA, And is it realy junk (superfluous)?
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3answers
160 views

How is the size of a gene defined?

Is there an agreed definition as to how many nucleic acid bases constitute a gene? If not, why not? I'm not sure I understand how the exact sizes of genes are defined.
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0answers
30 views

How do I know if the tRNA gene is under purifying selection from looking at a sequence dataset?

I'm having trouble figuring out how to tell if a tRNA gene is under purifying selection, just by looking at its sequence dataset. Such as this one:
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1answer
4k views

Why is the function of lacA (encoding thiogalactoside transacetylase) not clearly understood?

It's almost half a century since the lac operon was discovered but isn't it weird that the precise role of transacetylase isn't clearly understood ? Here a wikipedia article with a link to a journal ...
3
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1answer
55 views

Perplexing by the way of estimating the shared or different genes between humans and chimps

We share 98.5% genes with chimps (it means we have 98.5% same DNA sequeces ),so there is about one percent difference .It means we can approximately differ from them by one base pair every hundred ...
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2answers
80 views

Is there a genomic code for nucleosome positioning?

What does a genomic code for nucleosome positioning in eukaryotes actually mean? By the code is it right to think that specific DNA sequences favour nucleosomes and others don't? I see that there for ...
3
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0answers
27 views

What is the effective population size of a simple two deme metapopulation?

I am confused as to how to compute the effective population size $N_e$ of a theoretical structured population. Let's consider here a simple case study. Imagine a 2-deme metapopulation. Each deme is ...
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0answers
43 views

Is there an evolutionary advantage associated with migraine? [duplicate]

I have read Wikipedia article on Genetics of migraine headaches and I don't buy it Because genetics influence susceptibility to migraine, it can be shaped by evolution. Fitness-impairing ...
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0answers
48 views

What types of species can produce genetically identical offspring? [closed]

Talking about identical twins, triplets, etc. I'm curious which types of species are able produce genetically identical offspring. Let's limit the scope to species that reproduce sexually and ...
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0answers
19 views

What does high level science actually say about the gay gene? [duplicate]

There is a lot of talk about genetics in the contemporary debate on the morality of homosexual behavior (and bisexual behavior, hereafter implied). As I understand the issue, the thought is not that ...
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1answer
29 views

What is the relationship between independent assortment and cross over?

During meiosis, the independent assortment will be made first and then cross over will be made. I am so confused, what is the difference between this two process? I looked at the diagram on internet....
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144 views

The human has 46 double chromosomes or simple chromosomes?

What I mean: does the human cell have 46 of these: or 46 of these: Thank you in advance.
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1answer
85 views

How likely is it that a person's progeny has an inheritable disorder based on this pedigree?

Case study: A person (let's just call him "John") had 3 aunts that died back in the 1950's in early childhood due to an unknown form of neuromuscular disorder. One died at birth, one at 2 years and ...
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0answers
21 views

Effects of pulverizing liquid nitrogen frozen tissue by by pestle and mortar

Does RNA, DNA or protein molecule break during pulverizing (liquid nitrogen) frozen tissue by pestle and mortar. As I want to make cDNA for qPCR, this is very important to me to know this.
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2answers
100 views

Can animals also get Down syndrome?

I heard that animals cannot get Down syndrome or trisomy. Is that true and why can't they get it? They also have chromosomes.
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50 views

Can we infect with “bad” genes other organisms? [closed]

We know that some organism's DNA stay with human for life (Herpes) and we also can, i think, design such "gene" that can interact with human's DNA-polymerase very intensive. If we attached this gene ...
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2answers
68 views

Are heterozygotes always fitter than homozygotes? Can inbreeding be beneficial?

Inbreeding is mostly not very good because when there is a 'disease' in one allele, the other could/would take over the function. But when you have two of the same genes/alleles, do they, or could ...
2
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0answers
41 views

Has a restriction enzyme ever been tagged?

As part of an experiment that I am preparing, it would seem necessary for me to tag a restriction enzyme (HaeIII to be exact) with GFP. I began researching its domains to determine whether to tag the ...
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15 views

Difference in associated SNPs in GWAS

I noticed that when GWAS studies are being replicated, some SNPs near a gene known to cause a trait are enriched in frequency in those with the trait. However, among the different studies, the most ...
2
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0answers
44 views

Amplified Fragment Length Polymorphism (AFLP) primers

I am trying to blast AFLP primer sequences to the genome to find the locations of the AFLP markers. However, I can't seem to find full alignments for the primers on the genome. For example, in the ...
4
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2answers
634 views

Why is the strength of genetic drift inversely proportional to the population size?

I saw a concept on the Internet that says "the strength of genetic drift is inversely proportional to the population size". I don't know why they are inversely proportional? Can somebody explain? ...
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14 views

H is the set of all possible Diplotypes that are consistent with genotype data

I am new to Biology.SX. I have a statistics background, and have almost zero knowledge in genetics. I am trying to understand some things related to genetics in a certain paper of biostatistics. ...
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433 views

Lac operon: How can lactose enter the cell in the absence of lactose permease?

My textbook states that lactose permease...transports lactose into the cell and When lactose is added to the growth medium, the lactose molecules bind to the other site on the repressor ...
2
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1answer
104 views

How to retrieve logical expression (KO based) for reactions from KEGG?

Whether a module is complete or not can easily be checked by evaluating the Definition entry associated with the module; e.g. in module M00010, it is given by <...
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1answer
38 views

Distribution of Exon and Intron Sizes

Goal I am trying to get a distribution of Exons and intron sizes in Three-Spined Stickleback (Gasterosteus aculeatus). Data downloaded I downloaded some data from Ensembl. More precisely, I went ...
3
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2answers
62 views

Mutating a protein without mutating the gene?

Is it possible to mutate a region of a protein (says about 300 amino acids long) without actually mutating the gene? One possible way that I can think of is to use RNAi and specifically block that ...
2
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1answer
1k views

Definition and example of Gene Variant

Could someone clearly define what a gene variant is with an example. I am totally confusing myself with SNPs, alleles, variants and how the major and minor allele are defined. An example with gene ...
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17 views

What do recessive/dominant alleles actually mean in terms of modern genomics? [duplicate]

In Mendelian genetics, we discuss phenotypes, which are specified by the alternative versions of genes called alleles. In terms of peas, the phenotype "round pea" encoded by one allele of a gene is ...
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1answer
58 views

Current state of Gene Therapy [closed]

I am interested in learning about attempts to treat adult individuals suffering from a genetic disease in which the underlying changes in the DNA of the gene are understood. (i) Are there approaches ...
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2answers
105 views

What are sex linked traits?

Which of the two definitions of sex-linked trait is correct? Traits controlled by genes present on the non-homologous region of sex chromosomes are called sex-...
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5answers
19k views

Do we get 1/4 of our genes from each grandparent?

I know that we get half of our genes from each parent, but does it necessarily mean we get 1/4 of our genes from each grandparent? Or is it possible that we might get say 30% from one grandparent, 20% ...
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1answer
43 views

What are silent carrier traits? [closed]

I couldn't find a definition but I have come to know the following from google search: People who are carriers of a thalassemia gene show no thalassemia symptoms and might not know they're ...
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20 views

Links between Genetics and Personality Types

This topic was visited briefly in the thread, Genetic Effects on Personality, but I was surprised not to find more on it. (Is there a taboo I don't know about? What's the ethical stance on this ...
4
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1answer
150 views

Non-monotonic knock-out effects in prokaryotes

Typically, when performing gene-knockout, the experimenters select one gene to remove/replace-with-junk and then see if the prokaryote can still undergo fission. If it continues to reproduce then the ...
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23 views

Lyonization and Turner's syndrome

If lyonization is basically inactivation on X chromosome, and Turner's syndrome patients have only one existing X chromosome, what is the difference between healthy women with inactivated X chromosome ...
3
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1answer
676 views

Can DNA & RNA be considered as nature's programming language?

The final frontier of Biological Sciences could be considered understanding the effects of variation in the DNA (and RNA). If after fertilization the DNA of the zygote could be genetically ...
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590 views

3 flaws of genes from the perspective of a programmer [closed]

Having a double helix structure seems like a waste of space. In programming you would have a single array and just before mitosis you would double the single helix. Having an exact copy of a cromatid. ...
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95 views

What are Codominant vs Dominant Genetic Markers?

When talking about types of genetic markers, the adjective "dominant" and "codominant" are often used. I don't fully understand their definitions and found contradicting definitions. Foll and ...