Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Breeding Southern Right Whales Genetics

I don't know much about biology. I just like watching David Attenborough videos and this made me curious. I just watched this video about breeding Southern Right Whales, and these two quotes puzzled ...
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117 views

How genetically similar are worker ants from the same colony?

I've been reading https://en.wikipedia.org/wiki/Ant and it says If the egg is fertilised, the progeny will be female diploid; if not, it will be male haploid. Since the males have only one set ...
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Dominant model Disease SNP

Say that you have genotyped a SNP in a case control setting, and get the following result AA AB BB Cases 17 51 29 Controls 39 44 20 where A ...
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22 views

What the gene variation detection result can tell us about a cancer [duplicate]

We do a research on a particular cancer, now we have a result of the gene variation detection . What next steps do we need to do? we don't have a clear picture about this. Can you give us some ...
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36 views

How do biologists quantify “gene expression” in experiments?

I've read papers which contain statements such as "control of gene expression is critical in biological processes". How exactly does one quantify "gene expression"? Isn't gene expression an umbrella ...
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1answer
31 views

Why does meiotic recombination disrupt the independent assortment of genes on the same chromosome?

There are many sources that say that genes that are "linked" by being on the same chromosome assort with each other -- that when an allele is passed on that the gamete containing said allele will also ...
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50 views

Population size and genetic drift - What are the evidences?

Wright-Fisher model From the Wright-Fisher model of genetic drift, the random sampling of allele from one generation to the next is taken from a binomial distribution with parameters $2N$ and $p$, ...
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1answer
22 views

Methods for varying insert size in E. coli clones

I'm writing my master's thesis proposal, and I need to improve the solution-behavior of some truncated protein domains which have previously shown poor solubility when expressed in E. coli. To ...
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41 views

What further research can the result of gene variation detection be used for [closed]

We do a research on a particular cancer (for e.g. breast cancer). Now, we have a result for the gene variation detection (VCF file). What next steps do we need to do? We don't have a clear picture ...
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58 views

Which strand of a gene specifies a protein? [closed]

A gene is a segment of DNA (I hope double stranded) and each strand when transcribed form a mRNA and after being translated a protein. As from each gene there are two proteins that are being formed. ...
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3answers
79 views

Can I figure out the identity of my grandparent from this information? [closed]

I know all my family up to my grandparents, with the exception of the grandfather on my mother's side. At the time my mother was conceived, my grandmother was having an affair so no one in my family ...
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29 views

Can the restless leg syndrome may have been caused due to natural selection? [closed]

Disclaimer: I don't know how much restless the leg has to be, in order to be considered a syndrome. RLS runs not only in my family but also several people in the locality. My hypothesis is that RLS ...
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46 views

Directed evolution: Point mutation vs Insertion-Deletion vs Shuffling

When attempting enzyme function improvement via Directed Evolution I can see three different strategies to generating variation for the gene sequence: Point mutations Insertion / Deletions Shuffling ...
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32 views

Is there a way to identify a species of tree?

My family has been passing down seeds from a lemon tree for about 3 generations now, There is some controversy about its origin or species. The lemons look like tangerines and when cut the pulp is ...
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1answer
49 views

How many people in the world have bad eyesight?

I was watching this ted.ed episode and heard it was around 500,000 but that didn't sound right-- does anyone know?
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1answer
35 views

A doubt on Introgression

Wikipedia says that Introgression, also known as introgressive hybridization, in genetics is the movement of a gene (gene flow) from one species into the gene pool of another by the repeated ...
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1answer
44 views

How can a haploid plant be bisexual?

According to Wikipedia: Meiosis is a specialized type of cell division that reduces the chromosome number by half. This process occurs in all sexually reproducing single-celled and multicellular ...
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3answers
98 views

Relationship of the DNA of a eukaryotic gene to the 5'-UTR of its mRNA

In eukaryote pre-mRNA I am having a little trouble grasping exactly what the 5 prime untranslated region is defined as. It seems that it could be defined as the difference in pre-mRNA between the ...
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2answers
69 views

Infer gene frequency within a species over time

I was reading Karlsson et al. (2014) and I came into this: A selected variant that increases rapidly in frequency in the past ~250,000 years can be detected as an unusual reduction in genetic ...
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1answer
21 views

Measuring tumor heterogeneity [closed]

I would like to ask if there's any method (established or not) in order to quantify heterogeneity found in mutations occuring in primary neoplasms and metastatic lesions (either common or private) and ...
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1answer
61 views

What is the difference between multiple allelism and polymorphism?

Multiple allelism is defined as "the existence of more than two alleles of the same gene within a population." Polymorphism is "the occurrence of more than two distinct phenotypes of a trait in a ...
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25 views

How do genetic logic gates work?

Recently researchers at MIT have developed genetic logic gates which can be built into programs. How do these "genetic logic gates" work? "The language is based on Verilog, which is commonly used to ...
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1answer
73 views

Pink Grasshoppers

The area I found this grasshopper was Canyon Country, California, USA In a desert/field area. I have been reading up on grasshoppers because I recently came into possession of a pink grasshopper (It ...
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1answer
54 views

Data on Gene Position in Human Genome

I am trying to get some data on gene position in the human genome and I need some help What I tried I downloaded ...
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41 views

DNA replication : binding

Regarding an activator, does the C amp cap complex, bind to the coding strand, the template strand, or both?
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42 views

No. of genes in chromosomes. phenotype

Why do cells need all the genes of all the 22 pairs (excluding the 2 X- or Y-chromosomes) of autosomes in every somatic cell, when each and every cell which is specialised for its function does not ...
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1answer
37 views

Heritability of trait stronger from one sex over another?

Given a trait that can be expressed (and measured) in both parents (e.g weight, height, strength, speed), are there ever traits in the child that correlate better with one sex parent than the other? ...
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49 views

mutant and variant differentiation

Can anyone clearly differentiate between a variant and a mutant in genetics. I am confusing these terms a bit, as the evolutionary aspect also comes to my mind.
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How to safely conserve my current DNA methylation marks?

I read the Wikipedia article on DNA methylation Let's say I want to extract and then stock my current DNA methylation marks somewhere so that I can use it safely 20 years in the future for a medical ...
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125 views

Are alleles equally sized?

If alleles occur at the same locus on a chromosome, does that mean they are of the same size? I was under the impression that they were, but I saw a gel electrophoresis testing different alleles of ...
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47 views

Is $F_{ST}$ a probability and a correlation coefficient?

$F_{ST}$ is one of the most famous and most important statistics of all of evolutionary biology. Yet, many people misunderstand it or misuse the classical results from the literature on $F_{ST}$ ...
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2answers
94 views

Is it possible to have different genes in different parts of our body?

I want to understand genetic mutation specially in the context of multicellular organisms like humans. I studied biology only till high school and I can’t fully understand wikipedia pages on this ...
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27 views

Do any gaps in DNA during cell division (meiosis in particular) lead to crossover?

I have some gaps in the knowledge abour crossover. I know, that crossover is connected with reparation process. I'd like to know if all gaps in chromosomes lead to crossover (reparation based on 2d ...
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2answers
59 views

Grouping OMIM disease codes

I have ~100 sets of genes, and each set includes between 2 and 70 genes. I'd like to perform an enrichment analysis on each of these sets to test if they're enriched for OMIM disease labels. However, ...
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56 views

Do plants have distinctive DNA genomes from each other like humans do?

Can exact same species of plant have a distinct genome from others of same exact species growing nearby or in a different place/country etc. ? Can a leaf be traced to the the exact plant based on DNA ...
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67 views

Are identical twins clones? [closed]

Identical twins have the same genetic make up but they differ in development so are they in a way clones?
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76 views

Can difference in the expression potential of alleles lead to dominance?

Several hour ago I was in thoughts what allele dominance really means on molecular level. As we know from basic genetics, if the organism had Aa type of some gene ...
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16 views

What is the best test for SNV clustering?

I am looking for a method to cluster single nucleotide polymorphisms based on clinicopathologic data (mainly receptor immunoistochemistry). So far, I've came up with only two that handle dummy ...
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Predicting alternative transcript sequence and probability from a single SNV

I am currently studying a small number of non coding SNPs in terms of their contribution to the cancer phenotype. All are obtained from massive parallel sequencing on a specific gene panel, utilizing ...
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42 views

Trouble understanding overlapping genes.

I read the wikipedia passage on overlapping genes. https://en.wikipedia.org/wiki/Overlapping_gene The Tandem overlaps they speak of make sense to me, as I understand that their are different reading ...
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1answer
27 views

Synthesis of an additional DNA in Pachytene and Zygotene [closed]

I've read, that in Pachytene and Zygotene additional DNA material is synthesized, about 0,3, 0,1% respectively. Why is it so?
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37 views

Why are some genomic regions sequenced more than the others?

We have to normalise read count data from RNA-Seq experiments in order to account for the fact that some genomic regions are mapped more than others. i.e. we get the tags per million reads (TPM). In ...
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33 views

Are all genes transcribed in differentiated cells?

My textbook tells me that it’s specific transcription factors that allow for a different set of genes to be expressed in different cells (differential gene expression). My book gives the example of ...
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131 views

Are males taller than females?

Is there any scientific evidence that males are taller than females? And the reason why they are taller (please include genes or hormones that accounts for human growth and how they are affected in ...
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19 views

Molecules, Targets and Isoforms

I have a question. Given a molecule A and two isoforms of a gene X, Y, and the knowledge that A targets X. Can I infere from this anything about whether A targets Y? As a motivation think about ...
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97 views

An experiment to test if a bacterial resistance gene is on the plasmid or chromosome?

So I have an E.coli strain phenotypicall resistant to the antibiotics ampicillin and rifampicin. How do I test if the AmpR gene is carried on a plasmid and not on the chromosome? In summary, I ...
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19 views

Coefficient of Inbreeding - calculating for very large family tree

I have a very comprehensive family tree of many thousands of horses going back dozens of generations. I now wish to calculate the COI for every animal in the entire tree. I have seen that there are ...
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1answer
43 views

Cloning Ice Age Lion Cubs

It was just on the news that scientists discovered "Two cubs in Russia's Sakha Republic last August in a near-perfect state". And the South Koreans and Russians are attempting to clone these extinct ...
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175 views

Construct a restriction map of a linear fragment of DNA using the following data?

I've attempted to do the single digests, and the double digests, but cannot complete the map.... I've attached what I've done so far DNA Sizes of Fragments (bp) uncut DNA 900 DNA cut with EcoRI ...
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111 views

Is it possible to create a restriction map using python? [closed]

I have some fragments of DNA from single and double digests using three different restriction enzymes. I'm trying to construct a restriction map of a linear fragment of DNA. The map needs indicate the ...