Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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How does GC-content evolve?

Background GC-content refers to the frequency of base pairs that are either C or G in the genome, or in other words the number of GC base pairs divided by the addition of the number of GC base pairs ...
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Heterozygosity under genetic drift

The wright-Fisher model of genetic drift is: $$p_{ij} = \binom{2N}{j}\left(\frac{i}{2N}\right)^j \left(1- \frac{i}{2N}\right)^{2N-j} $$ ,where $\binom{2N}{j}$ is a binomial coefficient. From this ...
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Troubleshooting for Agarose Gel Electrophoresis

SI ran my 2% agarose gel on constant voltage (100 V). For a few times it worked at CV but, after a week or so the machine would automatically switch to constant current by itself. And this only ...
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Is it possible for a brown eyed parent to have blue eyed child?

Here's the story: A young man has stunning blue eyes. On his mother's side are lots of instances of blue eyes, but on his father's side is no history of blue eyes. When he was born with these bright ...
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Hardy-Weinberg Equilibrium: To compute probability of finding two siblings (random mating)

I've been working a little with M. G. Bulmer's Principles of Statistics (Dover, 1979) and cannot see how to properly compute half of one question. This should be a basic probability computation, but I ...
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Which disorders are fully concordant?

I work in neuroscience, mostly Alzheimer's disease (AD), with some work in autism spectrum disorder (ASD). The work is in gene regulation and epigenomics. I'm familiar with monozygotic twin (MZ) ...
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Genetics problem-Height of a plant

An inbred strain of plants has a mean height of 24cm. A second strain of the same species also has a mean height of 24cm. When these plants are crossed the F1 are also 24cm in height.However, when the ...
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Why is the human body hair not uniformly colored?

Most of my body hair is black however my lip hair is light brown/blonde the rest of my beard region is black. Since hair color is genetic what causes this?
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Possible Genotypes — Linked Genes

Please consider the following question: Genes A and B are located on the same chromosome. If two individuals with the genotype shown below are crossed, which genotype could be formed? Let / ...
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How was the Huntington's disease gene's location found?

I read in the book "Why we get sick." by Nesse and Williams that: Steady detective work and fabulous luck have enabled geneticists to pinpoint the Huntington's gene on the short arm of ...
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How does gene expression work in an adult organism? Is everything encoded everywhere?

The color of a person's eyes are genetically predetermined. If I knew how and in which gene(s) colors are encoded, I could change these genes in the ovary and sperm and thus change the eye color of ...
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Codominance and Partial dominance [closed]

The following genetic tree is given regard the fur color of some animal. The color determined by one gene that have two alleles and 3 genotypes: black, white and inlaid. I've been asked to ...
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Advantages of pain sensation?

The hazards of congenital insensitivity to pain (CIP) are well-known. This question is about the obverse: what selective advantage, if any, does the normal sensation of pain confer? I'm thinking of ...
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Population Genetics Question

Can someone please help with this question? Here is my working (just in case it is not clear: 1/300*1/30*1/2) but is this actually correct or do I need to multiply by 0.5 once again? I appreciate ...
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What is TILLING?

How does TILLING (Targeting Induced Local Lesions in Genomes) work? What is needed to perform a TILLING experiment, and what kind of information can we get out of it?
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What are the methods for infering genetic interactions?

Is there a classification of methods for inferring genetic interactions? I mean some work published, utilizes genetical genomics data. Is this possible with expression data alone? And how about ...
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How can a YAC be screened against a cDNA library and a cosmid library of genomic DNA to find a gene?

I am reading fw2.2: A Quantitative Trait Locus Key to the Evolution of Tomato Fruit Size (doi: 10.1126/science.289.5476.85). The authors are trying to find the gene that makes tomatoes bigger. As far ...
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How does a new species survive without suffering inbreeding?

Just what the title states. The thought came from reading When has an organism evolved enough to be called a new species? I'm probably wrong but I understand new species happen sporadically rather ...
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Hill-Roberston effects and effective population size

From this article, first page, middle of the second column: Even if harmful alleles do not become fixed, they can still reduce the efficacy of selection on neighbouring loci through a process ...
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Why does the slope of parent-offspring regression equals the heritability in the narrow sense?

Background ---- Notations and assumptions ---- let $W_{ij}$ be the fitness associated to the genotype $AiAj$. $x$ is the frequency of the allele $A1$ in the population. The frequency of the allele ...
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Fisher's Fundamental Theorem of Natural Selection

Ronald Fisher discovered what he, with humility, called the Fundamental Theorem of Natural Selection. This theorem says (in its modern terminology): The rate of increase in the mean fitness of any ...
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What does min mean?

I read that "trp operon is located at 27 min on E.coli chromosome." What does "min" mean ?
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Brainbow fluorescence labeling technique

I have this picture describing the Brainbow system here: The paper I am reading says it uses Cre-lox recombination to express a certain color. If the cell in question was expressing a yellow ...
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How can a recessive allele propagate until they manifest?

Suppose a specific gene has two possible alleles. In a given population all members have only the dominant one. By a mutation on member receives the first recessive allele of that population. Is it ...
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Do white Australians have a distinct look?

Background I've heard from many people working in tourism or similar industries that, white Australians can be recognized as Australian solely by their facial features. Being Australian myself I've ...
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Knockout Rat Phenotype Database?

Is there a database where I might list the phenotype of a certain rat knockout and/or search for other similar phenotypes? There is a International Mouse Phenotyping Consortium, which has the goal ...
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Understanding DNA supercoiling

While trying to understand DNA supercoiling, I came across these lines in the book Genetics by Ursula Goodenough : All natural DNA is superhelical. The axis of the duplex itself follows a ...
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Quantitative Traits Genetics

Can someone please help with this question? I'm not so sure whether part A should be 11 inches or something else. Also, is part B correct
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How do I calculate the change in allele frequency in a haploid population under selection?

From this book For simplicity, let us consider a haploid organism and assume that the frequencies of alleles $A_1$ and $A_2$ are given by $x$ and $y=1-x$, respectively. We also assume that the ...
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Why doesn't recombination occur in male Drosophila?

"Males do not show meiotic recombination, facilitating genetic studies." For a while I have known that this phenomenon occurs, this quote comes from the Wikipedia page on Drosophila melanogaster, ...
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DNA adaptation in human life

Does our DNA adapt by human lifetime? Or do we have the same genetic information from birth to death? I mean: What is usually called "evolution" means "natural selection" like this: ...
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What is the role of hippo signalling in oral squamous cells

What role do hippo signalling have on squamous cells in oral health & diseases
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Could mating/recombination be responsible for evolution of entirely novel features?

The diploid chromosomal architecture is rather interesting. For example, because of diploidy we Humans have to mate. Of course in that sense, because diploid organisms often have mate, this has led to ...
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How many transcription factors are there?

In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to ...
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Paracentric Inversion and Mutations Question Help Needed

Would someone please be able to help with questons 3 or 4. (one of the at least please) please don't report his as off-topic. first, this is NOT a homeowork question. It's a practice question I am ...
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What is the standing genetic variation?

I am reading this review. In the first part, the author introduces Standing Genetic Variation, described as: STANDING GENETIC VARIATION Allelic variation that is currently segregating within a ...
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Sexual Differentiation in Monoecious plants with unisexual flowers

In monoecious plants having unisexual flowers (eg Zea Mays, Ricinus Communis etc), there must be some mechanism as to produce two sexually distinct flowers from the same genotype. Since both the type ...
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Functioning of BRCA2

I know that BRCA2 interacts with RAD51 to repair DNA damage. But how exactly does it function ? What are the other proteins that interact with it ?
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Data analysis of transcriptome sequencing data

I want to learn more about the data analysis and statistics on transcriptome sequencing data. I would like to read some important papers of the field and books and maybe some MOOCS, if they are ...
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Gibson assembly using NeBuilder

I am supposed to construct a plasmid that contains features from two other plasmids. My strategy is to generate three fragments form the two other plasmids. I was encouraged to try Gibson assembly, ...
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Examples of animals with different number of chromosomes that can interbreed?

When I was first started to write this question, I wanted to know how species evolve to have a different chromosomal arrangement, such as having two pairs of chromosomes instead of one? However, I ...
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Drosophila Crosses

I have 2 transgenic lines of Drosophila. I would like to cross them and get both transgene in the same fly. To start this cross, does it matter which fly is female or male? Or as long as the female is ...
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Do recessive alleles really exist?

This question may seem illogical to some, but I seriously have this doubt. I searched google for some proofs but they were extremely complex and I couldn't understand anything. I was just wondering ...
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X Linked Hardy Weinberg Equilibrium Problem

In a given population under Hardy Weinberg equilibrium, 40.0% of men have hemophilia. What is the probability that a random man and random woman will have a daughter with hemophilia? I think the ...
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Southern/Western blot analysis and pedigree diagram? Help needed. [duplicate]

Hello everyone. I urgently need help with this question please. I have filled in the blanks using the results in the figure provided in the sheet. However, for number (b) is a little hard to ...
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Quantitative Differences : DNA and Gene

After HGP, we are not having many databases which consist of several notepad files of ATCG.... Can we distinguish quantitatively a given A,T,C and G stretch as DNA or Gene?
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Gene Complementation Question

Hi everyone! Here is a diagram of a genetics complementation problem. My main concern is regarding number 3d. I'm assuming that in this case, it would be complementary interaction and thus ...
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How do mosquitoes maintain telomere length?

While the vast majority of eukaryotic organisms maintain their chromosome ends (telomeres) via telomerase, an enzyme system that generates short, tandem repeats on the ends of chromosomes, other ...
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Genotypic distribution of a population with two characteristics and linkage

I am currently doing some research into distributions and probabilities with Mendellian genetics. I came across this problem that I cannot seem to wrap my head around. Given that the population has ...