Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Is it possible that by mutation a human could see infrared or other 'colours'?

Incoming light reacts with the several types of cone cells in the eye. In humans, there are three types of cones sensitive to three different spectra, resulting in trichromatic color vision. Each ...
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42 views

Mitochondrial Genetic code

We know that the genetic code is universal. My query is why the mitochondrial genetic code is different from universal genetic code?
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Statistically, why is the number of mutated genes in eggs treated with chemical mutagenesis one?

Excerpted from the Guide to Research Techniques in Neuroscience [1]: In chemical mutagenesis, a scientist applies a mutagenizing chemical, such as ethyl methane sulfonate (EMS) or N-ethyl-N-...
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What are in common between transcription factors?

In terms of their structures (primary to tertiary) and locations? Why do they have these commonalities? Or are any of these commonalities critical to their functions?
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Is Chargaff's rule really applicable?

Chargaff's rules states that DNA from any cell of all organisms should have a 1:1 ratio (base Pair Rule) of pyrimidine and purine bases and, more specifically, that the amount of guanine is equal to ...
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Relationship of bases in a gene to amino acids

One of my study questions for a biology test was: A gene contains 1200 bases. How many codons will be on the mRNA immediately after transcription? My initial answer was 400 codons, because 1200 ...
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Basic Genotyping

As a disclaimer, I'm from a computer science / statistics background, working on some bioinformatics problems. I've got some genotyping data (VCF from Exome Sequencing), and I'm struggling to get my ...
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Hydrogen bonding and the blocking thereof in nucleic acids during nuclear processes

In transcription, RNA polymerase unwinds the DNA double helix and begins attaching RNA nucleotides to the template strand. In its wake, the DNA double helix closes back—this is only natural, seeing as ...
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Does DNA polymerase I require a $3^\prime$ end?

DNA polymerase III adds nucleotides in the $5^\prime \rightarrow 3^\prime$ direction because it can only add nucleotides to the $3^\prime$ end of the previous nucleotide. This is why it requires a ...
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Is complete genetic linkage possible?

Linkage is the tendency of genes on the same chromosome to remain together during the process of inheritance. Is it possible that two genes will remain linked generation after generation without any ...
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Are there examples of selection on males influencing female phenotypes?

I've been studying selection on female body color in a sexually dimorphic species and am intrigued by the possibility that selection on males, whether it be through sexual or natural selection, may ...
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Is it possible for two creature in the same order and have odd haploid chromosome species to reproduce

Take the degu and the rat for example. The degu has 29 chromosome pairs Rats have 21 chromosome pairs. They are only share the same order ( Rodentia ) Would it be possible for them to reproduce? ( ...
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What type of point mutation and chromosomal mutation cause Albinism in humans?

First of all, I know that OCA1 (Oculocutaneous Albinism Type 1) is autosomal recessive which means that both parents-who are unaffected-have to pass down one copy of a mutated gene in order to ...
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Why are there different species of bacteria?

The usual (high school or intro to bio) explanation for diversification of species comes from multicellular, usually sexually reproducing organisms, and seems to be closely tied to the biological ...
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107 views

Is eye colour of Drosophila a polygenic trait or an X-linked trait?

I have seen examples of various eye colours in Drosophila and they have been described both as "X-linked" and "polygenic". I thought these were mutually exclusive. Is Drosophila eye colour polygenic ...
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81 views

What is the probability of genetic reincarnation? [closed]

Parents pass on 23 chromosomes to their children, with a 50/50 chance for each chromosome. Considering that people of a families lived over millennia in the same region the abundance of some ...
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1answer
98 views

What's the mechanism or structure responsible for new species genetic code generation? [closed]

I always had this question in mind. I think, If humans find answer to it then we can trigger the next evolution of human specie. What is the mechanism or structure responsible for evolution ? I don't ...
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Follow-up to The Red Queen by Matt Ridley? [closed]

I just finished reading The Red Queen: Sex and the evolution of human nature by Matt Ridley. Since this book is over 20 years old, I was wondering if more recent research made part of the book ...
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1answer
34 views

Obtaining a mapping of RefSeq ACs to Uniprot ACs

I am trying to obtain a mapping for RefSeq Accession Numbers to Uniprot Accession Numbers. I can write a script to do this for a list of RefSeq ACs like this: ...
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What is the definition of a mutation?

There are two alleles that determine the sensitivity of a person to Coumadin (a medicine for blood thinners used to treat a stroke etc). Sometimes you encounter the terminology that one has a mutation ...
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Distinguishing Father from Brother

Given the (non-identical) DNA sequences of two men and the knowledge that the second man is either the father, brother, or son of the first man, is the DNA useful in determining which of these three ...
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What separates gene loci?

Introns are sections of noncoding DNA that separate exons within a gene locus. However, between different gene loci, I also would assume there to be noncoding regions of DNA. What are these regions ...
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Crossing over and exon shuffling?

Campbell Biology 10e, in discussing the functions of introns, writes: The presence of introns in a gene may facilitate the evolution of new and potentially beneficial proteins as a result of a ...
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44 views

How should one interpret heritability? Is it related to $R^2$?

From Wiki: Heritability estimates are often misinterpreted if it is not understood that they refer to the proportion of variation between individuals on a trait that is due to genetic factors. It ...
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Is the DNA different in each type of cell? What DNA is passed to offspring?

Our body contains many different types of cells and each of those cells have their own DNA (correct me if wrong) like skin cells their own DNA that makes them skin cells instead of muscle cells. So ...
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Solving a Pedigree Between Heterozygous Half-Cousins

A man who is a known heterozygous carrier of oculocutaneous albinism marries his half-cousin (they share one common grandparent) as shown in the pedigree below. This trait is transmitted as a fully ...
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What does characterization mean in a genomics context?

"The resulting libraries of gene sequences allow CDC and other laboratories to compare the genes of currently circulating influenza viruses with the genes of older influenza viruses and viruses ...
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XNAs as a Genetic material [closed]

I heard there is a new genetic material called XNAs.I wanted to know more about this.Does anyone about XNAs as genetic material?
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Is the relative amount off junk DNA a measure of an organisms complexity? [closed]

A rice plant contains as much active DNA (protein coding) as a human being. Can this be a sign that the more junk DNA the nucleus of a cell contains, the more complex the organism is that develops?
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Gene centromere distance in yeast tetrads

I'm not getting the formula for calculating distance between a centromere and a gene in a Neurospora tetrad. Formula: Distance(gene to centromere)= 100 * 0.5(tetrads showing MII segregation)/(total ...
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Amplified Fragment Length Polymorphism (AFLP) primers

I am trying to blast AFLP primer sequences to the genome to find the locations of the AFLP markers. However, I can't seem to find full alignments for the primers on the genome. For example, in the ...
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Explain allelic complementation at molecular level

I know that Allelic complementation is a phenomenon where two recessive loss-of-function allele generate a functional gene product by compensating each others' defect. But I don't get how do they ...
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39 views

Are scientist able to correct mutiple gene defect in our body by using CRISPR

Are scientist able to correct mutiple gene defect in whole body by using CRISPR recently? AS i know, it is in a beginning stage
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Was the frequency of mutations more during primitive earth due to radioactivity?

Primitive earth was more radioactive (or was it really?) according to radiometric analysis of C14 which suddenly appeared at 4250 million years in the Hadeon eon. Is it possible that ancient high ...
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RAD sequencing: choosing the appropriate enzyme?

I’m studying Darwin’s finches genome and I say in some articles that the researchers used restriction enzymes to cut the DNA in their double digest RAD protocol. They are using EcoRI and MseI (GAATTC ...
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Can heritability be deduced from a correlation coefficient?

I am trying to understand the concept of heritability and from what I can gather, the heritability of a factor (say birth weight) must be closely related to the correlation coefficient of that factor ...
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285 views

Growth factors vs. mitogens

According to Campbell Biology, A growth factor is a protein released by certain cells that stimulates other cells to divide. and according to Wikipedia, A mitogen is a chemical substance ...
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Incomplete dominance with gain-of-function allele

Can somebody site an example of incomplete dominance with gain-of-function mutation?
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1answer
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Genetic coding question, amino acid to base relationship

I'm studying for a test and I am confused by these problems/statements. How many amino acids will 18 bases code for? Answer: 6. I got this right. If a certain complete protein has 33 amino acids ...
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1answer
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BWA-MEM single strand or doublestrand alignment

In whole genome secondary analysis does BWA-MEM use a double stranded fasta reference or are reads aligned to only one, single stranded fasta reference?
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“Heterozygotic expection” - when heterozygote differs from both homozygotes, but homozygotes are similar

For simple 2-alleles genetic model {a,A} and corresponding quantitative trait Q is typically true that Q(aa)>=Q(aA)>=Q(AA) or conversely Q(AA)>=Q(aA)>=Q(aA). For example, dominance means that Q(...
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Comparing genetics [closed]

Compare the possible effect on an individual of knowing that they have genes predisposing them to type-2 diabetes and the dominant allele that causes Huntington's disease. I am not sure about the way ...
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What is working definition for female infertility?

I've studied infertility and found that its quite complex to define. However, I came to know about a useful working definition of infertility; which was " Failure to achieve pregnancy". Few days later ...
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Why do Major and Minor grooves exist in dna strands? [closed]

I've been trying to find what causes the periodic appearance of major and minor grooves in DNA but have not yet been successful. Geometrical explanations would also be appreciated as I cannot ...
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343 views

Gene and alleles

This is a multiple choice question: Consider a gene, ABC, which codes for an enzyme involved in the metabolism of sugars. There are two known alleles of this gene, ABC1 and ABC2. Which statement ...
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How difficult is it to make a shRNA/miRNA/siRNA to silence/knockdown NaV1.7 voltage gated sodium channels in humans?

There have been various research projects that experimented with shRNA/miRNA/siRNA to specifically silence/knockdown NaV1.7 voltage gated sodium channels in small animals like rats & guinea pigs. (...
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Is HSV-vector-mediated miRNA expression in dorsal root ganglia stable?

My question is on the following article: "Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy" My question is, do ...
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How to identify genes in Ralstonia that synthesize PHB and promote granule formation?

The compound polyhydroxybutyrate (PHB) is of considerable industrial interest as a biodegradable substitute for plastic. PHB is synthesized from glycerol by the bacterium Ralstonia eutropha. PHB ...
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1answer
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How was gene therapy able to cure diseases through the transformation of actively dividing cells?

I thought that gene therapy, when performed on target cells that regenerate themselves constantly, can be effective for a limited time only. I.e., the effect gradually wears off after a while, ...
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The Semi-Conservative Model of DNA Replication: Question

My Campbell's Biology textbook contains the following diagram related to the semi-conservative model of DNA replication proposed by Watson and Crick. I have highlighted where my confusion arises in ...