Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

learn more… | top users | synonyms

6
votes
1answer
188 views

Are all chromosomes equally susceptible to mutation?

The humans have been around for a few million years, other organisms longer yet. Changes that occur in the genome and propagate (may) eventually throw a new species ... or atleast branch off the old ...
6
votes
1answer
177 views

What is the difference between xDNA and yDNA?

Wikipedia states that: xDNA contains expanded bases, in which a benzene ring has been added, which may pair with canon bases, resulting in four possible base-pairs (8 bases:xA-T,xT-A,xC-G,xG-C, 16 ...
6
votes
1answer
283 views

Have there been attempts to identify Chomsky's “language mutation” in humans?

I'm not versed in either biology or linguistics so please forgive any naiveties I may commit. I've learned that Noam Chomsky thinks that language is a result of a single genetic mutation in humans. ...
6
votes
2answers
203 views

Effect of single-gene overexpression in the cell's response

Which are the factors that modify the overall gene differential expression by introducing a vector for single-gene overexpression? If you overexpress a gene for a protein involved in signal ...
6
votes
1answer
258 views

Are gene variants at different loci also called alleles?

I think the title says it. I always read that alleles are gene variants at a given locus, which confuses me. Thanks!
6
votes
1answer
69 views

How well supported is the hypothesis that aging is mainly caused by the number of mutations in tissues?

I heard the hypothesis, that the (main) reason of aging is the increasing number of mutations in body tissues. The higher the number of mutations is, the older tissue is. Is this true? And how well ...
6
votes
1answer
126 views

Bicoid regulation of hunchback

I'm learning about development via the example of Drosophila embryogenesis. I understand that bicoid regulates hunchback, among other genes. My question whether the regulation is direct or indirect? ...
6
votes
1answer
42 views

Are there mechanisms that limit the amounts of time conjugation and F-plasmid transfer can happen? If yes, what are they?

Not all bacteria have acquired F-plasmids through conjugation. Some of the mechanisms for this are unsuccesful conjugation events (mechanical disruption), no transfer due to integration in bacterial ...
6
votes
1answer
68 views

“Enhancers” of enhancers?

I am looking for examples (if any) of genomic regions which regulates the activity of enhancers, either augmenting or reducing it. Essentially some kind of enhancers (or repressors) of enhancers to ...
6
votes
1answer
226 views

What percentage of the (additive or not) genetic variance is explained by the 'n'- most important loci?

Standard models in population genetics look up at the evolution of few loci which impact fitness. The variance in fitness is determined by the genetic variance and the environmental variance (and the ...
6
votes
2answers
46 views

Can a woman possessing 1 mutated allele show attenuated color-vision deficiency?

Women possess two X chromosomes. However, during development, when the embryo has about 32 - 64 cells, one of these chromosomes is randomly inactivated (in each cell) by an lncRNA named Xist. As a ...
6
votes
0answers
70 views

How was the cama's life expectancy computed?

A cama is a hybrid between a male dromedary camel and a female llama. The first cama was born on January 14, 1998, yet on the Wikipedia page it is said that a cama's life span is 30–40 years. How was ...
5
votes
3answers
3k views

How does Artificial Selection work?

As far as I know for evolution to work mutations are necessary. Mutations are the raw material on which natural selection works. But mutations are always completely random and human beings have no ...
5
votes
3answers
446 views

A free book/resource for learning genetics?

I took an undergrad class in genetics. I felt it was not too intensive and I do not feel prepared for grad school (if I can manage to get in.) Does anyone know of a preferably free resource for ...
5
votes
3answers
221 views

Why don't flies avoid the motorway?

Flies have a short lifespan, therefore evolution should technically happen over a shorter period of time (years). Flies die all the time from getting hit by cars on the motorway. Those flies that ...
5
votes
2answers
93 views

How to identify genes required for biofilm formation

This is just a homework question: Q: Let’s assume that there is an unknown set of E. coli genes that are required for biofilm formation. Describe a genetic experiment you could perform to try to ...
5
votes
3answers
156 views

Can genetically modified genes jump to bacteria in the eater's intestine?

The Guardian ran an article a while back talking about GM gene's jumping to bacteria in an eater's intestine. Has other research confirmed this phenomenon?
5
votes
1answer
1k views

The genetic and physiological origins of laughter?

This Wikipedia article defines laughter in many terms, such as... "a visual expression of happiness, or an inward feeling of joy" and "a part of human behavior regulated by the brain, ...
5
votes
2answers
182 views

Functions of the CFTR gene?

I am a senior in high school and I am studying cystic fibrosis. I don't quite get the function of the CFTR gene as this is my first time dealing with this type of heavy scientific info. I had ...
5
votes
1answer
539 views

What do the signs +/+ +/- mean in this image?

I don't understand what this graph is supposed to explain, especially what the signs +/+ or -/- mean. I just know it characterises some rats.
5
votes
2answers
152 views

How is gene expression estimated?

I'm reading this fantastic article on estimating body time: Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles and one ...
5
votes
1answer
100 views

What are the different ways an exon gets spliced?

Exons are produced by more than one mechanism, e.g. splicing out introns after transcription, if I remember correctly. Please list all mechanisms.
5
votes
1answer
184 views

Where do amino acids get attached to tRNA and where is it synthesized?

Some very basic parts of transcription/translation seem to be left out in various literature. I can't find the answer to this anywhere: How exactly is tRNA synthesized? I realize that mRNA is ...
5
votes
1answer
99 views

What is an operon?

What is an operon in a eukaryotic cell, and how does it regulate the expression of genes? I've already read Wikipedia, but it is not enough clear to me. Unfortunately my knowledge in genetics are very ...
5
votes
2answers
815 views

Why is the DNA codon table “equal” to the RNA codon table

Before anything else please pay attention of the double quotes on the "equal" in the title - I know they are not equal, but you will understand in a bit. If I look at the DNA codon table here or in ...
5
votes
1answer
101 views

Plasmid in the nucleus and gene expression

If we insert a plasmid into a human nucleus that contains exact copy of gene and all relevant promoters to produce some human protein, will the cell create functional protein from that plasmid only ...
5
votes
2answers
182 views
5
votes
2answers
2k views

Are Asians more genetically homogenous than other races?

I've heard that Asians (I'm not entirely sure which subgroup was being referred to) tend to be more genetically homogenous than other races, with people of African lineage being on the other end of ...
5
votes
3answers
273 views

Can extinct animals be cloned?

Scientists have found mammoth blood, and are planning to clone a mammoth. How does one go from having its blood to a full blown living mammoth? Is it possible? Why does it matter if the blood is ...
5
votes
1answer
864 views

Smallest unit on which selection can act

Traditionally, the individual was considered to be the smallest unit on which Natural Selection (NS) acts. Today, we usually consider the gene as being the unit of NS. Of course, we should also ...
5
votes
2answers
185 views

How does a new species survive without suffering inbreeding?

Just what the title states. The thought came from reading When has an organism evolved enough to be called a new species? I'm probably wrong but I understand new species happen sporadically rather ...
5
votes
1answer
653 views

Genetic carrier Pedigree of Recessive Traits

A human male and female couple with normal colored ears discover that, in both of their families, their fathers (who have normal ears) each had siblings with red ears. Red ears is a rare autosomal ...
5
votes
1answer
1k views

What is the distinction between F' plasmid and R plasmid?

Is there a difference between an F' plasmid that has taken up a chromosomal gene that conveys antibiotic resistance, and an R plasmid? Is a bacterium containing an R plasmid and yet lacking an F+ ...
5
votes
1answer
108 views

Understanding recombination scoring in family pedigrees

I am having some problems understanding recombination, and I am not sure what element I am missing here. This figure is an example from my text book. The pedigree belongs to a family with an autosomal ...
5
votes
1answer
240 views

Restriction Mapping - Homework question

I have trouble in solving this exercise. Exercise A circular plasmid of 10,000 base pairs (bp) is digested with two restriction enzymes,A and B, to produce a 3000 bp and a 2000 bp bands when ...
5
votes
1answer
475 views

Microsatellite shifts (peak calling) GeneMapper! Thesis help!

I'm a masters student attempting to conduct a parentage analysis on a population of fish for my thesis. My advisor and post-docs haven't been very helpful, so I need some help! I have dinucleotide ...
5
votes
1answer
1k views

What generates variation in a species?

What is the biological mechanism behind the variation within sexually reproducing species? Obviously, the children are combinations, to differing degrees, of their parents. But how does the variation ...
5
votes
1answer
81 views

Doubt on genomic code for nucleosome positioning?

I was reading "A genomic code for nucleosome positioning" (by Eran Segal et al). And I am having 2 doubts. The figure(b) in this image from the paper shows the graph of fraction (3-bp moving ...
5
votes
1answer
115 views

Can human mRNA be translated in vitro by prokaryotes?

As the genetic code is universal, can mRNA from a human cell be correctly translated by a prokaryote in a in vitro translation system?
5
votes
2answers
419 views

Correlation between genome size and mutation rate?

Martin Nowak in his book "Evolutionary Dynamics" talks about a given correlation between genome size and mutation rate. What correlation does exactly exist between these two concepts? Is it a ...
5
votes
2answers
8k views

What's the difference between shotgun sequencing and clone based sequencing?

What are the main differences between shotgun sequencing and clone based sequencing?
5
votes
1answer
2k views

What is a focal copy number variation?

Often, genetics studies, especially genome wide ones, talk about "focal copy number variations" in genes or regions of the chromosome. I know what a copy number variation is. What does "focal" mean, ...
5
votes
1answer
41 views

what is linkage disequilibrium supposed to measure?

During reading about genetics I came across with the term of linkage disequilibrium, and I do not really understand what it supposed to mean. What is linkage disequilibrium? My current understanding ...
5
votes
1answer
44 views

How does de-myelination occur in multiple sclerosis?

From what I understand, only the oligodendrocytes are affected in multiple sclerosis, and they are attacked by T cells which cross the blood-brain barrier. This leads me to two questions: How is the ...
5
votes
1answer
51 views

Components of the concept of Developmental Noise?

Developmental noise is a concept that correspond to the amount of possible phenotypic variance of a given genotype in a given environment. Intrinsic noise (aka Cellular noise) is a component of ...
5
votes
3answers
252 views

How do you merge SNP data with a reference genome?

My Data I have a 23andMe file listing SNPs in the form: ...
5
votes
2answers
57 views

Is there are practical lower limit to gene length in E. coli?

Question is rather self-explanatory. Putting aside other post-transcriptional factors like rate of degradation of transcript, what is the smallest gene ever reported to have successfully been ...
5
votes
1answer
24 views

How to calculate the percentage of heterozygous cells based on a gene map

I've encountered the following question and am quite stumped by it. A female with genotype AABBCC has been hybridized with a male that has the genotype aabbcc. The first generation (F1) has been ...
5
votes
1answer
53 views

How do I know which alleles the parents have?

I have the following assignment where I am to look at the "tree" (not sure the english word) and assign whether or not they can be autosomal dominant or recessive as well whether they can be X-linked ...
5
votes
1answer
74 views

Examples of genes involved in plastic responses

Adaptive plasticity involves sensing the environment and responding adaptively to it. Intuitively, I would think that this process may ask for a more or less complex genetic machinery of regulation of ...