Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Does a large effective population size result in faster decay of linkage disequilibrium (LD)?

I am thinking about an invasive species that was introduced into North America just a few (<20) generations ago. Using microsatellite genotypes (105 loci), I have identified almost no significant ...
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168 views

Precursor miRNA and a mature miRNA

What is the main difference between a precursor miRNA and a mature miRNA? It is often the case that we have more than one precursor miRNA but only one mature miRNA. The miRNA-seq data contains only ...
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Have novel interactions or pathways been predicted by GRN or PPI data and later confirmed by experiment?

I've been learning about the gene regulatory network (GRN) and protein-protein interaction network (PPI) recently. I've found a huge amount of extremely interesting papers about how biological network ...
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Looking for a gene in my raw genetic data. What are the possible causes for this?

Obviously, I barely know what I am talking about. But I want to find the "MUC5B promoter polymorphism rs35705950" in my RAW genetic data from 23andMe. (see this ...
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37 views

Why are the genomes of some trees so large?

For example, the current longest known genome belongs to a tree: http://motherboard.vice.com/read/the-largest-genome-ever-sequenced-belongs-to-a-tree I have heard that this could potentially be ...
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Why aren't introns found on the ends of pre-RNA?

We recently learned in genetics class that exons always cap the ends of nascent RNA. I have been trying to figure out the reason why introns can't instead be found on the ends instead of exons. The ...
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49 views

Why do we use DNA sequencing methods such as shotgun?

I am learning about DNA cloning for the first time. What I understand is that, in order to clone DNA, we break-up the original gene into shreds. Then try to piece it back together. Why exactly do we ...
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35 views

Heterochromatin production limitations

Currently playing with some ideas for a project and needed some guidance. I am wondering, both in Drosophila melanogaster and in general, is the amount of heterochromatin a cell/nucleus can produce ...
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106 views

What is the purpose of back-crossing mice for multiple generations?

Occasionally I will come across articles that refer to back-crossing mice of one strain onto the background other another strain (e.g., C57Bl6). They do not explicitly state the purpose for doing so, ...
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51 views

Mode of inheritance - DYT1 Dystonia

Homozygous DYT1 mutation carriers have not been reported in humans. Does this mean that the mode of inheritance for dystonia (DYT1) is autosomal dominant? This to me implies that if one has both ...
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627 views

What is the standing genetic variation?

I am reading this review. In the first part, the author introduces Standing Genetic Variation, described as: STANDING GENETIC VARIATION Allelic variation that is currently segregating within a ...
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563 views

Examples of animals with different number of chromosomes that can interbreed?

When I was first started to write this question, I wanted to know how species evolve to have a different chromosomal arrangement, such as having two pairs of chromosomes instead of one? However, I ...
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Publicly available genotype data?

I am a statistician and I'd like to test my new method on biological data. For this I am looking for genotype data for a number of individuals. That is, I am looking for something like this: ...
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What is the genetic basis of blood type (ABO) system?

What is the genetic basis of the A/B/B+/O/etc. blood type system? Are there definitive loci that correspond to each or can multiple different genotypes produce the same antigen profile? Also, is the ...
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1k views

Knockdown of long noncoding RNA (lncRNA) - how is it done?

I don't work at the wet lab and don't know all the details about the knockdown techniques. My question is: How lncRNA knockdown is done? For example - you have lncRNA that is functional in the ...
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363 views

What is an epistasis group?

I have been trying to wrap my head around the concept of epistasis for a couple of days now, and I think I understand it, at least at a basic level, but I still don't understand some of the ways that ...
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60 views

What accounts for size variation in breeds of dogs?

My assumption is that dogs vary so much in size because of artificial selection pressures coming from human breeders, but are there genetic loci that roughly determine approximate size? Do other ...
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69 views

What's in a Name: Statistical Genetics

The novice often performs population calculations using what is referred to as Mendelian Genetics. Soon after the publication of Mendel's results; Hardy and Weinberg presented their results after the ...
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Which is better against genetic mutations? Asexual or Sexual Reproduction?

In terms of genetics, which type of reproduction is better against adverse mutations? I understand a bit of Muller's Ratchet—in which asexual organisms accumulate a number of deleterious mutations in ...
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38 views

What is the difference between a DPY-10, DPY-11, and DPY-13?

My TA mentioned these three mutations of C. elegans since we started working with the worms but seems to skip over what the differences are...
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110 views

Are people genetically predisposed to being interested in specific fields/ideas? How does specialization occur?

I'm not sure if I formulated my question well, but I'm curious about a couple statements made by Steven Pinker and and James Heckman. In this interview: ...
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Heterozygosity under genetic drift

The wright-Fisher model of genetic drift is: $$p_{ij} = \binom{2N}{j}\left(\frac{i}{2N}\right)^j \left(1- \frac{i}{2N}\right)^{2N-j} $$ ,where $\binom{2N}{j}$ is a binomial coefficient. From this ...
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43 views

How do mosquitoes maintain telomere length?

While the vast majority of eukaryotic organisms maintain their chromosome ends (telomeres) via telomerase, an enzyme system that generates short, tandem repeats on the ends of chromosomes, other ...
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250 views

Possible Genotypes of 4 Alleles of Adh

There are four alleles of Adh which are Adh-1, Adh-2, Adh-3 and Adh-4. Their respective frequencies are 0.11, 0.84, 0.01 and 0.04. What are the Hardy-Weinberg frequencies of the possible 10 ...
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94 views

Chromatin shearing: what is it and what are the effects of high-sensitivity?

I am reading a paper which discusses a complex (MSL-DCC) involved in dosage compensation of the drosophila X-chromosome. Descriptions of the complex's structure and function are given in the papers ...
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123 views

How did the activities of protocells become inheritable?

I have learned that first a protocell came to exist and its characteristics came to be passed on by genetic material. So how come genes for all the activities come to incorporate into genetic ...
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Low complexity region and relaxed selection

I'm reading a text (Wagner, 2007) on identifying positive selection. In paper, the author says that low complexity regions are known to be associated with relaxed selection. I'm trying to understand ...
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260 views

What factors govern the variable age of onset in Huntington's Disease?

"Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems." As we all know, this genetic disease ...
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Mutation in axillary buds of trees overcoming self-incompatability?

I seem to recall from either reading or lecture that there have been instances of trees that are self-incompatible accumulating enough mutations in an axillary bud that the resulting branch was able ...
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374 views

Can parents' learned traits be transmitted genetically?

I am wondering whether a behavioral trait (e.g. fear or stress experienced in the lifetime of the parent) can be transmitted genetically to its offspring? I understand that a behavioral tendency for ...
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87 views

Predictable microchimerism

I read in New Scientist recently that microchimerism occurs between previously born siblings and grandparents, not just the mother. Do we know which parts of the genome are likely to be transferred? ...
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Pedigree Probability of Autosomal Recessive Trait

Here is a pedigree: The trait is autosomal recessive. The question is: What is the probability that the bottom 2 people (4 and 5) have a child with the trait? I tried doing ...
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129 views

Is there some genetic variance underlying music appreciation?

Is there any research done on the genetic variance for Music appreciation? If not, why is there no genetic variance for this trait?
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Horizontal gene transfer versus convergent evolution

There are several often noted examples of convergent evolution (eyes, bat/bird wing evolution etc.) How do we rule out horizontal gene transfer in these cases?
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How does GC-content evolve?

Background GC-content refers to the frequency of base pairs that are either C or G in the genome, or in other words the number of GC base pairs divided by the addition of the number of GC base pairs ...
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Brainbow fluorescence labeling technique

I have this picture describing the Brainbow system here: The paper I am reading says it uses Cre-lox recombination to express a certain color. If the cell in question was expressing a yellow ...
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Activation Of Embryonic Genome

Embryonic gene activation is a process by which the embryo begins to transcribe its newly formed genome.As the embryonic gene activation occurs during early stages the paternal genome may not have any ...
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How diverse are dogs in their traits other than appearance?

I've asked this question about dogs not so long ago, and the short answer was - dogs are the most diverse looking species of mammals because they got a small number of genes that have a big impact on ...
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59 views

What are treatable foetal conditions during pregnancy?

What are different foetal conditions during pregnancy that could be treated with appropriate prenatal genetic testing? I only know that pregnant women are encouraged to take certain supplements to ...
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Predicting progeny of recessive mutations using recombination

I was asked this question on a test and got it wrong, but I'd like to know how to do it. The answers are shown in the blanks below: You are studying two recessive mutations in the fruit fly D. ...
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Circulating factors affecting human health/longevity

Circulating factors present in young mice have been shown to promote rejuvenation of aged mice, suggesting that tissues have inherent capabilities to regenerate, and circulating factors may be ...
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How often does bacterial transformation happen?

I have been reading: M. Dröge, A. Pühler, W. Selbitschka, "Horizontal gene transfer among bacteria in terrestrial and aquatic habitats as assessed by microcosm and field studies", Biol. Fertil. ...
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At what rate do chromosomal rearrangements occur?

How often does chromosomal rearrangements occur? i.e. what is the rate of chromosomal rearrangements? I am interested about these kind of chromosomal rearrangements that are passed on to the ...
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Do the eggs for larger litters come from the same meiosis events, or different ones?

There are some species of animals that give birth to more than one pup at a time. In these species, are the fertilized eggs all from one or a limited group of meiosis processes, or are they from ...
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54 views

A Genetic linkage problem [closed]

I have recently switched from electronics to computational biology. So having some hard time with my homeworks. Can someone guide me on this problem? Consider 6 genes A, B, C, D, E, F, G. Some ...
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Data analysis of transcriptome sequencing data [closed]

I want to learn more about the data analysis and statistics on transcriptome sequencing data. I would like to read some important papers of the field and books and maybe some MOOCS, if they are ...
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Could miniaturization be used to protect endangered large species?

In some animals (like dogs) size seems like it's controlled mostly by just a few genes (IGF1, and the genes that repress it). I'm curious: (1) Does other miniaturization takes a similar route (for ...
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What are polytene bands, and why are they there?

Drosophila polytene chromosomes have been particularly useful in genetic research, as it made cytogenetic gene mapping possible with very little effort. This was primarily accomplished due to polytene ...
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81 views

Papers linking telomeres and aging [closed]

I'm currently writing a piece of work about telomeres and aging, and wondered if you could share some good papers you've either read or know of.
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Terminology question: the scope of an allele in an organism

Let us consider a gene FOO with novel type foo. If I were discussing an organism that has inherited foo in every cell during classical zygote formation, then I would ordinarily just say that the ...